Maurice Langhinrichs
@mlanghinrichs.bsky.social
Modelling clonal dynamics in developmental and stem cell biology, @DKFZ, Höfer Group
Reposted by Maurice Langhinrichs
New pre-print from Thomas Höfer, Daniel Hübschmann, @haas_lab and myself, with first authors @Esther_RCorrea @FloGrunschlager and Tamar Nizharadze doi.org/10.1101/2025... @DKFZ @NCT_HD @ChariteBerlin @hi_stem_lab BIH & MDC
A kinetics-based model of hematopoiesis reveals extrinsic regulation of skewed lineage output from stem cells
Residing at the top of the hematopoietic hierarchy, long-term hematopoietic stem cells (HSCs) are capable of self-renewal and sustained blood cell regeneration. Over the past decades, single-cell and ...
doi.org
February 5, 2025 at 10:55 AM
New pre-print from Thomas Höfer, Daniel Hübschmann, @haas_lab and myself, with first authors @Esther_RCorrea @FloGrunschlager and Tamar Nizharadze doi.org/10.1101/2025... @DKFZ @NCT_HD @ChariteBerlin @hi_stem_lab BIH & MDC
Reposted by Maurice Langhinrichs
'In this review, we discuss the communication between mast cells and neurons in host-protective avoidance behavior and expulsion reflexes and present a concept of mast cells as converters of signals from IgE and other stimuli into organ-specific or systemic reflexes.'
#Immunology #Neuroimmunology
#Immunology #Neuroimmunology
Beyond classical immunity: Mast cells as signal converters between tissues and neurons
Mast cells act as “signal converters,” translating immunological and tissue signals
into host-protective behaviors. They sense antigen and possibly toxins driving avoidance
behavior, which can prevent...
www.cell.com
January 17, 2025 at 12:43 AM
'In this review, we discuss the communication between mast cells and neurons in host-protective avoidance behavior and expulsion reflexes and present a concept of mast cells as converters of signals from IgE and other stimuli into organ-specific or systemic reflexes.'
#Immunology #Neuroimmunology
#Immunology #Neuroimmunology
Reposted by Maurice Langhinrichs
Are you looking for a #PhD position in the interdisciplinary field of #immunology #development #cellbiology? Do you love #macrophages? #FOR5775 is hiring!! Find details here: macrophagenetwork.com/news-2/
Pls repost👇 #immunosky
Pls repost👇 #immunosky
News – My WordPress
macrophagenetwork.com
December 21, 2024 at 3:02 PM
Are you looking for a #PhD position in the interdisciplinary field of #immunology #development #cellbiology? Do you love #macrophages? #FOR5775 is hiring!! Find details here: macrophagenetwork.com/news-2/
Pls repost👇 #immunosky
Pls repost👇 #immunosky
Reposted by Maurice Langhinrichs
Let the new spatial barcoding era begin!
🚨𝐏𝐨𝐥𝐲𝐭𝐨𝐩𝐞 𝐢𝐬 𝐡𝐞𝐫𝐞!
New preprint by my colleague @dpostrach.bsky.social:
𝐏𝐨𝐥𝐲𝐭𝐨𝐩𝐞 uses 𝐮𝐩 𝐭𝐨 𝟓𝟏𝟐 𝐜𝐨𝐥𝐨𝐫𝐬 𝐭𝐨 𝐭𝐫𝐚𝐜𝐞 𝐜𝐥𝐨𝐧𝐞𝐬 𝐢𝐧 𝐬𝐢𝐭𝐮 as they grow, expand and travel. And cheap readout using IBEX.
Can't wait to see all the fields that will profit from this tool!
🚨𝐏𝐨𝐥𝐲𝐭𝐨𝐩𝐞 𝐢𝐬 𝐡𝐞𝐫𝐞!
New preprint by my colleague @dpostrach.bsky.social:
𝐏𝐨𝐥𝐲𝐭𝐨𝐩𝐞 uses 𝐮𝐩 𝐭𝐨 𝟓𝟏𝟐 𝐜𝐨𝐥𝐨𝐫𝐬 𝐭𝐨 𝐭𝐫𝐚𝐜𝐞 𝐜𝐥𝐨𝐧𝐞𝐬 𝐢𝐧 𝐬𝐢𝐭𝐮 as they grow, expand and travel. And cheap readout using IBEX.
Can't wait to see all the fields that will profit from this tool!
Polytope: High-resolution epitope barcoding for in vivo spatial fate-mapping https://www.biorxiv.org/content/10.1101/2024.11.20.624484v1
Polytope: High-resolution epitope barcoding for in vivo spatial fate-mapping https://www.biorxiv.org/content/10.1101/2024.11.20.624484v1
Tracing the fate of individual cells and their progeny remains a challenging task. While imaging-bas
www.biorxiv.org
December 1, 2024 at 10:45 PM
Let the new spatial barcoding era begin!
🚨𝐏𝐨𝐥𝐲𝐭𝐨𝐩𝐞 𝐢𝐬 𝐡𝐞𝐫𝐞!
New preprint by my colleague @dpostrach.bsky.social:
𝐏𝐨𝐥𝐲𝐭𝐨𝐩𝐞 uses 𝐮𝐩 𝐭𝐨 𝟓𝟏𝟐 𝐜𝐨𝐥𝐨𝐫𝐬 𝐭𝐨 𝐭𝐫𝐚𝐜𝐞 𝐜𝐥𝐨𝐧𝐞𝐬 𝐢𝐧 𝐬𝐢𝐭𝐮 as they grow, expand and travel. And cheap readout using IBEX.
Can't wait to see all the fields that will profit from this tool!
🚨𝐏𝐨𝐥𝐲𝐭𝐨𝐩𝐞 𝐢𝐬 𝐡𝐞𝐫𝐞!
New preprint by my colleague @dpostrach.bsky.social:
𝐏𝐨𝐥𝐲𝐭𝐨𝐩𝐞 uses 𝐮𝐩 𝐭𝐨 𝟓𝟏𝟐 𝐜𝐨𝐥𝐨𝐫𝐬 𝐭𝐨 𝐭𝐫𝐚𝐜𝐞 𝐜𝐥𝐨𝐧𝐞𝐬 𝐢𝐧 𝐬𝐢𝐭𝐮 as they grow, expand and travel. And cheap readout using IBEX.
Can't wait to see all the fields that will profit from this tool!
Reposted by Maurice Langhinrichs
#macrophage #barcoding 🤯 Time to get rid of the "fetal liver monocyte" origin for resident macrophages?!? Congrats to the Rodewald lab for this work!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Holistic genetic barcoding reveals a lineage tree of tissue macrophage development
Tissue macrophages are crucial for organ development and homeostasis, yet the developmental routes leading to tissue macrophages remain controversial. By combining unbiased Polylox barcoding with comp...
www.biorxiv.org
December 1, 2024 at 11:46 AM
#macrophage #barcoding 🤯 Time to get rid of the "fetal liver monocyte" origin for resident macrophages?!? Congrats to the Rodewald lab for this work!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Maurice Langhinrichs
🎉 Next preprint on its way!
#Polylox #barcoding + computational modelling meets #macrophage #development!
We used 𝐮𝐧𝐛𝐢𝐚𝐬𝐞𝐝 𝐏𝐨𝐥𝐲𝐥𝐨𝐱 𝐛𝐚𝐫𝐜𝐨𝐝𝐢𝐧𝐠 to trace thousands of embryonic progenitor clones and map their development into tissue-specific macrophages.
Happy reading!
doi.org/10.1101/2024...
#Polylox #barcoding + computational modelling meets #macrophage #development!
We used 𝐮𝐧𝐛𝐢𝐚𝐬𝐞𝐝 𝐏𝐨𝐥𝐲𝐥𝐨𝐱 𝐛𝐚𝐫𝐜𝐨𝐝𝐢𝐧𝐠 to trace thousands of embryonic progenitor clones and map their development into tissue-specific macrophages.
Happy reading!
doi.org/10.1101/2024...
Holistic genetic barcoding reveals a lineage tree of tissue macrophage development
Tissue macrophages are crucial for organ development and homeostasis, yet the developmental routes leading to tissue macrophages remain controversial. By combining unbiased Polylox barcoding with comp...
doi.org
December 1, 2024 at 11:38 PM
🎉 Next preprint on its way!
#Polylox #barcoding + computational modelling meets #macrophage #development!
We used 𝐮𝐧𝐛𝐢𝐚𝐬𝐞𝐝 𝐏𝐨𝐥𝐲𝐥𝐨𝐱 𝐛𝐚𝐫𝐜𝐨𝐝𝐢𝐧𝐠 to trace thousands of embryonic progenitor clones and map their development into tissue-specific macrophages.
Happy reading!
doi.org/10.1101/2024...
#Polylox #barcoding + computational modelling meets #macrophage #development!
We used 𝐮𝐧𝐛𝐢𝐚𝐬𝐞𝐝 𝐏𝐨𝐥𝐲𝐥𝐨𝐱 𝐛𝐚𝐫𝐜𝐨𝐝𝐢𝐧𝐠 to trace thousands of embryonic progenitor clones and map their development into tissue-specific macrophages.
Happy reading!
doi.org/10.1101/2024...
Reposted by Maurice Langhinrichs
Excited to share our preprint: Polytope, an epitope barcoding system, generating up to 512 unique color codes for in vivo lineage tracing. 🌈🧬 This tech enables spatial fate-mapping with unprecedented clonal and spatial resolution! doi.org/10.1101/2024... #SpatialBiology #LineageTracing #Polytope
Polytope: High-resolution epitope barcoding for in vivo spatial fate-mapping
Tracing the fate of individual cells and their progeny remains a challenging task. While imaging-based fate-mapping provides spatial information, it generally lacks complexity due to limited label div...
doi.org
December 3, 2024 at 9:41 AM
Excited to share our preprint: Polytope, an epitope barcoding system, generating up to 512 unique color codes for in vivo lineage tracing. 🌈🧬 This tech enables spatial fate-mapping with unprecedented clonal and spatial resolution! doi.org/10.1101/2024... #SpatialBiology #LineageTracing #Polytope