Larissa Frank
@larissafrank.bsky.social
Immunologist and Macrophage plus Barcoding enthusiast 🧬 @UniHeidelberg and @DKFZ
Pinned
Polytope: High-resolution epitope barcoding for in vivo spatial fate-mapping https://www.biorxiv.org/content/10.1101/2024.11.20.624484v1
Polytope: High-resolution epitope barcoding for in vivo spatial fate-mapping https://www.biorxiv.org/content/10.1101/2024.11.20.624484v1
Tracing the fate of individual cells and their progeny remains a challenging task. While imaging-bas
www.biorxiv.org
Let the new spatial barcoding era begin!
🚨𝐏𝐨𝐥𝐲𝐭𝐨𝐩𝐞 𝐢𝐬 𝐡𝐞𝐫𝐞!
New preprint by my colleague @dpostrach.bsky.social:
𝐏𝐨𝐥𝐲𝐭𝐨𝐩𝐞 uses 𝐮𝐩 𝐭𝐨 𝟓𝟏𝟐 𝐜𝐨𝐥𝐨𝐫𝐬 𝐭𝐨 𝐭𝐫𝐚𝐜𝐞 𝐜𝐥𝐨𝐧𝐞𝐬 𝐢𝐧 𝐬𝐢𝐭𝐮 as they grow, expand and travel. And cheap readout using IBEX.
Can't wait to see all the fields that will profit from this tool!
🚨𝐏𝐨𝐥𝐲𝐭𝐨𝐩𝐞 𝐢𝐬 𝐡𝐞𝐫𝐞!
New preprint by my colleague @dpostrach.bsky.social:
𝐏𝐨𝐥𝐲𝐭𝐨𝐩𝐞 uses 𝐮𝐩 𝐭𝐨 𝟓𝟏𝟐 𝐜𝐨𝐥𝐨𝐫𝐬 𝐭𝐨 𝐭𝐫𝐚𝐜𝐞 𝐜𝐥𝐨𝐧𝐞𝐬 𝐢𝐧 𝐬𝐢𝐭𝐮 as they grow, expand and travel. And cheap readout using IBEX.
Can't wait to see all the fields that will profit from this tool!
Reposted by Larissa Frank
The i2 seminars are back on Thursday, April 17, at 4 pm with two talks by Dr. Bea Casati, Postdoc in the Papavasiliou Lab, and Larissa Frank, PhD student in the Rodewald Lab. Save the date and join us for a lively discussion!
@dkfz.bsky.social
@beacasati.bsky.social
@larissafrank.bsky.social
@dkfz.bsky.social
@beacasati.bsky.social
@larissafrank.bsky.social
April 8, 2025 at 8:25 AM
The i2 seminars are back on Thursday, April 17, at 4 pm with two talks by Dr. Bea Casati, Postdoc in the Papavasiliou Lab, and Larissa Frank, PhD student in the Rodewald Lab. Save the date and join us for a lively discussion!
@dkfz.bsky.social
@beacasati.bsky.social
@larissafrank.bsky.social
@dkfz.bsky.social
@beacasati.bsky.social
@larissafrank.bsky.social
Reposted by Larissa Frank
'In this review, we discuss the communication between mast cells and neurons in host-protective avoidance behavior and expulsion reflexes and present a concept of mast cells as converters of signals from IgE and other stimuli into organ-specific or systemic reflexes.'
#Immunology #Neuroimmunology
#Immunology #Neuroimmunology
Beyond classical immunity: Mast cells as signal converters between tissues and neurons
Mast cells act as “signal converters,” translating immunological and tissue signals
into host-protective behaviors. They sense antigen and possibly toxins driving avoidance
behavior, which can prevent...
www.cell.com
January 17, 2025 at 12:43 AM
'In this review, we discuss the communication between mast cells and neurons in host-protective avoidance behavior and expulsion reflexes and present a concept of mast cells as converters of signals from IgE and other stimuli into organ-specific or systemic reflexes.'
#Immunology #Neuroimmunology
#Immunology #Neuroimmunology
Reposted by Larissa Frank
Excited to share our preprint: Polytope, an epitope barcoding system, generating up to 512 unique color codes for in vivo lineage tracing. 🌈🧬 This tech enables spatial fate-mapping with unprecedented clonal and spatial resolution! doi.org/10.1101/2024... #SpatialBiology #LineageTracing #Polytope
Polytope: High-resolution epitope barcoding for in vivo spatial fate-mapping
Tracing the fate of individual cells and their progeny remains a challenging task. While imaging-based fate-mapping provides spatial information, it generally lacks complexity due to limited label div...
doi.org
December 3, 2024 at 9:41 AM
Excited to share our preprint: Polytope, an epitope barcoding system, generating up to 512 unique color codes for in vivo lineage tracing. 🌈🧬 This tech enables spatial fate-mapping with unprecedented clonal and spatial resolution! doi.org/10.1101/2024... #SpatialBiology #LineageTracing #Polytope
Reposted by Larissa Frank
Holistic genetic barcoding reveals a lineage tree of tissue macrophage development https://www.biorxiv.org/content/10.1101/2024.11.29.625985v1
Holistic genetic barcoding reveals a lineage tree of tissue macrophage development https://www.biorxiv.org/content/10.1101/2024.11.29.625985v1
Tissue macrophages are crucial for organ development and homeostasis, yet the developmental routes l
www.biorxiv.org
November 30, 2024 at 9:30 PM
Holistic genetic barcoding reveals a lineage tree of tissue macrophage development https://www.biorxiv.org/content/10.1101/2024.11.29.625985v1
Reposted by Larissa Frank
#macrophage #barcoding 🤯 Time to get rid of the "fetal liver monocyte" origin for resident macrophages?!? Congrats to the Rodewald lab for this work!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Holistic genetic barcoding reveals a lineage tree of tissue macrophage development
Tissue macrophages are crucial for organ development and homeostasis, yet the developmental routes leading to tissue macrophages remain controversial. By combining unbiased Polylox barcoding with comp...
www.biorxiv.org
December 1, 2024 at 11:46 AM
#macrophage #barcoding 🤯 Time to get rid of the "fetal liver monocyte" origin for resident macrophages?!? Congrats to the Rodewald lab for this work!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
🎉 Next preprint on its way!
#Polylox #barcoding + computational modelling meets #macrophage #development!
We used 𝐮𝐧𝐛𝐢𝐚𝐬𝐞𝐝 𝐏𝐨𝐥𝐲𝐥𝐨𝐱 𝐛𝐚𝐫𝐜𝐨𝐝𝐢𝐧𝐠 to trace thousands of embryonic progenitor clones and map their development into tissue-specific macrophages.
Happy reading!
doi.org/10.1101/2024...
#Polylox #barcoding + computational modelling meets #macrophage #development!
We used 𝐮𝐧𝐛𝐢𝐚𝐬𝐞𝐝 𝐏𝐨𝐥𝐲𝐥𝐨𝐱 𝐛𝐚𝐫𝐜𝐨𝐝𝐢𝐧𝐠 to trace thousands of embryonic progenitor clones and map their development into tissue-specific macrophages.
Happy reading!
doi.org/10.1101/2024...
Holistic genetic barcoding reveals a lineage tree of tissue macrophage development
Tissue macrophages are crucial for organ development and homeostasis, yet the developmental routes leading to tissue macrophages remain controversial. By combining unbiased Polylox barcoding with comp...
doi.org
December 1, 2024 at 11:38 PM
🎉 Next preprint on its way!
#Polylox #barcoding + computational modelling meets #macrophage #development!
We used 𝐮𝐧𝐛𝐢𝐚𝐬𝐞𝐝 𝐏𝐨𝐥𝐲𝐥𝐨𝐱 𝐛𝐚𝐫𝐜𝐨𝐝𝐢𝐧𝐠 to trace thousands of embryonic progenitor clones and map their development into tissue-specific macrophages.
Happy reading!
doi.org/10.1101/2024...
#Polylox #barcoding + computational modelling meets #macrophage #development!
We used 𝐮𝐧𝐛𝐢𝐚𝐬𝐞𝐝 𝐏𝐨𝐥𝐲𝐥𝐨𝐱 𝐛𝐚𝐫𝐜𝐨𝐝𝐢𝐧𝐠 to trace thousands of embryonic progenitor clones and map their development into tissue-specific macrophages.
Happy reading!
doi.org/10.1101/2024...
Let the new spatial barcoding era begin!
🚨𝐏𝐨𝐥𝐲𝐭𝐨𝐩𝐞 𝐢𝐬 𝐡𝐞𝐫𝐞!
New preprint by my colleague @dpostrach.bsky.social:
𝐏𝐨𝐥𝐲𝐭𝐨𝐩𝐞 uses 𝐮𝐩 𝐭𝐨 𝟓𝟏𝟐 𝐜𝐨𝐥𝐨𝐫𝐬 𝐭𝐨 𝐭𝐫𝐚𝐜𝐞 𝐜𝐥𝐨𝐧𝐞𝐬 𝐢𝐧 𝐬𝐢𝐭𝐮 as they grow, expand and travel. And cheap readout using IBEX.
Can't wait to see all the fields that will profit from this tool!
🚨𝐏𝐨𝐥𝐲𝐭𝐨𝐩𝐞 𝐢𝐬 𝐡𝐞𝐫𝐞!
New preprint by my colleague @dpostrach.bsky.social:
𝐏𝐨𝐥𝐲𝐭𝐨𝐩𝐞 uses 𝐮𝐩 𝐭𝐨 𝟓𝟏𝟐 𝐜𝐨𝐥𝐨𝐫𝐬 𝐭𝐨 𝐭𝐫𝐚𝐜𝐞 𝐜𝐥𝐨𝐧𝐞𝐬 𝐢𝐧 𝐬𝐢𝐭𝐮 as they grow, expand and travel. And cheap readout using IBEX.
Can't wait to see all the fields that will profit from this tool!
Polytope: High-resolution epitope barcoding for in vivo spatial fate-mapping https://www.biorxiv.org/content/10.1101/2024.11.20.624484v1
Polytope: High-resolution epitope barcoding for in vivo spatial fate-mapping https://www.biorxiv.org/content/10.1101/2024.11.20.624484v1
Tracing the fate of individual cells and their progeny remains a challenging task. While imaging-bas
www.biorxiv.org
December 1, 2024 at 10:45 PM
Let the new spatial barcoding era begin!
🚨𝐏𝐨𝐥𝐲𝐭𝐨𝐩𝐞 𝐢𝐬 𝐡𝐞𝐫𝐞!
New preprint by my colleague @dpostrach.bsky.social:
𝐏𝐨𝐥𝐲𝐭𝐨𝐩𝐞 uses 𝐮𝐩 𝐭𝐨 𝟓𝟏𝟐 𝐜𝐨𝐥𝐨𝐫𝐬 𝐭𝐨 𝐭𝐫𝐚𝐜𝐞 𝐜𝐥𝐨𝐧𝐞𝐬 𝐢𝐧 𝐬𝐢𝐭𝐮 as they grow, expand and travel. And cheap readout using IBEX.
Can't wait to see all the fields that will profit from this tool!
🚨𝐏𝐨𝐥𝐲𝐭𝐨𝐩𝐞 𝐢𝐬 𝐡𝐞𝐫𝐞!
New preprint by my colleague @dpostrach.bsky.social:
𝐏𝐨𝐥𝐲𝐭𝐨𝐩𝐞 uses 𝐮𝐩 𝐭𝐨 𝟓𝟏𝟐 𝐜𝐨𝐥𝐨𝐫𝐬 𝐭𝐨 𝐭𝐫𝐚𝐜𝐞 𝐜𝐥𝐨𝐧𝐞𝐬 𝐢𝐧 𝐬𝐢𝐭𝐮 as they grow, expand and travel. And cheap readout using IBEX.
Can't wait to see all the fields that will profit from this tool!