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mitoscientists.bsky.social
MitoMavericks
@mitoscientists.bsky.social
130 followers 110 following 17 posts
A platform for scientists and
physicians to share and discuss important discoveries related to the role of mitochondria in health and to advance mitochondrial science as a cornerstone of improving human health. Please tag us to amplify your contributions.
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mitoscientists.bsky.social
MitoMavericks @mitoscientists.bsky.social · Jan 5
Join mitoTT (mitochondria transfer and transplant) network. It comprises professionals from diverse sectors, including academia, biotech, pharma, investors, physicians, and entrepreneurs, to address challenges and create opportunities in the mitoTT field.
chat.whatsapp.com/BElX3Nn2swXA...
mito:TT:gators
WhatsApp Group Invite
chat.whatsapp.com
mitoscientists.bsky.social
November 24, 2025 at 5:27 AM
Reposted by MitoMavericks
cvasilescu.bsky.social
Rich collections of papers on #mitochondrialdisease from the last 2 weeks! 📚
biomed.news/bims-mitdis/...
biomed.news/bims-mitdis/...

@biomednews.bsky.social @mitoscientist.bsky.social
@gavinmcstay.bsky.social

Demethoxy-CoQ and NUDT5 in nucleotide synthesis
www.nature.com/articles/s42...
Uridine-sensitized screening identifies demethoxy-coenzyme Q and NUDT5 as regulators of nucleotide synthesis - Nature Metabolism
A uridine-sensitized CRISPR-Cas9 screening identifies demethoxy-CoQ as an alternative electron acceptor in the absence of CoQ, and NUDT5 as a regulator of de novo pyrimidine synthesis via its interact...
www.nature.com
November 23, 2025 at 11:59 AM
Reposted by MitoMavericks
cvasilescu.bsky.social
A new collection of papers on #mitochondrialdisease from #week45! 📚 💚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social

Mito complex III-derived ROS amplify immunometab changes in astrocytes and promote dementia
www.nature.com/articles/s42...
Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathology - Nature Metabolism
Barnett et al. disentangle the differential contribution of mitochondrial complex I- and complex III-derived ROS to astrocytic function, with CIII-derived ROS being a major driver of neuroinflammatory...
www.nature.com
November 9, 2025 at 12:53 PM
Reposted by MitoMavericks
cvasilescu.bsky.social
Great collections of papers on #mitochondrialdisease from #week42 and #week43! 📚
biomed.news/bims-mitdis/...
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social

Mito & psy stress regulation of FGF21 in humans
www.nature.com/articles/s42...
Mitochondrial and psychosocial stress-related regulation of FGF21 in humans - Nature Metabolism
FGF21 levels increase in response to acute mental stress in individuals with impaired mitochondrial OxPhos capacity, and correlate with stress-related neuroendocrine hormones and trait-level psychosoc...
www.nature.com
October 26, 2025 at 10:36 AM
Reposted by MitoMavericks
mitoscientist.bsky.social
Happy Diwali-The Festival of Lights
As we celebrate this beautiful festival that
symbolizes the triumph of light over darkness, knowledge over ignorance, and good over evil - let us rekindle the light within us to create a brighter future for all.

#Diwali #diwalicelebration #deepavali
October 20, 2025 at 3:21 AM
Reposted by MitoMavericks
cvasilescu.bsky.social
Fresh selection of papers on #MitochondrialDisease from #week41! 📚 💚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @mitoscientist.bsky.social @gavinmcstay.bsky.social

Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations
www.science.org/doi/10.1126/...
Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations
Mitochondrial synthesis of adenosine triphosphate is essential for eukaryotic life but is dependent on the cooperation of two genomes: nuclear and mitochondrial DNA (mtDNA). mtDNA mutates ~15 times as...
www.science.org
October 12, 2025 at 11:06 AM
Reposted by MitoMavericks
cvasilescu.bsky.social
#MitochondrialDisease papers from #week39! 📚 👇
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social

A few highlights below!
Ribonucleotide incorporation into mitochondrial DNA drives inflammation - Nature
Imbalanced nucleotide metabolism leads to age- and mtDNA-dependent inflammatory responses and senescence-associated secretory phenotype in senescence.
nature.com
September 28, 2025 at 10:06 AM
Reposted by MitoMavericks
mitoscientist.bsky.social
Delighted to participate in the exciting
symposium on "Artificial Intelligence in
Mitochondrial Medicine: emerging tools for diagnosis and monitoring

Hotel Galilei
January 23rd,2026
Pisa,Italy
October 2, 2025 at 12:54 AM
Reposted by MitoMavericks
cvasilescu.bsky.social
Interaction of the mitochondrial calcium/proton exchanger TMBIM5 with MICU1 | Communications Biology
www.nature.com/articles/s42...
Interaction of the mitochondrial calcium/proton exchanger TMBIM5 with MICU1 - Communications Biology
Genetic and biochemical evidence reveals a functional interaction between mitochondrial proteins TMBIM5 and MICU1.
www.nature.com
September 21, 2025 at 9:41 AM
Reposted by MitoMavericks
cvasilescu.bsky.social
To honour the #MitochondrialDisease #AwarenessWeek 💚 we bring a new collection of recently-published research papers related to mitochondrial disease:
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social

Cryo-EM of the prohibitin complex
Hong et al, Cryo-EM structure of the prohibitin complex in open conformation https://www.pnas.org/doi/10.1073/pnas.2512430122
September 21, 2025 at 9:18 AM
Reposted by MitoMavericks
mitoscientist.bsky.social
Tonight, shine a light of hope in green to support the mito community.
September 21, 2025 at 1:19 AM
mitoscientists.bsky.social
The amazing mitodancer! The real mito energy! 😂😂
September 7, 2025 at 3:30 PM
Reposted by MitoMavericks
cvasilescu.bsky.social
Last two weeks of literature relevant for #MitochondrialDisease! 📚

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social

Please browse the collections here! 👇
biomed.news/bims-mitdis/...
biomed.news/bims-mitdis/...
August 24, 2025 at 8:58 AM
Reposted by MitoMavericks
mitoscientist.bsky.social
💚 September 15–21 is Mitochondrial Disease Awareness Week-a time to spotlight diseases that are primarily due to defect(s)in mitochondria. Let’s stand with the mito community and help raise awareness for patients, families, and research.
#MitochondrialDisease #Awareness #HealthAdvocacy
September 1, 2025 at 4:33 AM
Reposted by MitoMavericks
cvasilescu.bsky.social
#MitochondrialDisease collection of papers from #week32! 📚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social

Highlights

Hypoxia ameliorates neurodegeneration and movement disorder in a mouse model of Parkinson's disease
Marutani et al, Hypoxia ameliorates neurodegeneration and movement disorder in a mouse model of Parkinson's disease https://www.nature.com/articles/s41593-025-02010-4
August 10, 2025 at 6:47 AM
Reposted by MitoMavericks
natmetabolism.nature.com
#Throwback 🧪

REVIEW | Mitophagy in human health, ageing and disease

L Ferrucci, D D’Amico et al
Mitophagy in human health, ageing and disease - Nature Metabolism
This Review discusses the role of mitophagy in cellular and organismal health and disease, with a specific focus on human ageing and evidence obtained in clinical studies.
bit.ly
July 27, 2025 at 3:08 PM
Reposted by MitoMavericks
jourdainlab.bsky.social
Our updated inventory of genes required for #OXPHOS & findings on #mito defects in #Menieres is now out at Cell Reports! 🎉

🧫 New galactose #CRISPR screen
🎯 481 genes required for #OXPHOS
⚙️ #FAM136A in IMS proteostasis
👂 Mito defects in #Menieres

www.cell.com/cell-reports...
An updated inventory of genes essential for oxidative phosphorylation identifies a mitochondrial origin in familial Ménière’s disease
Harhai and collaborators expand the catalog of genes essential for oxidative phosphorylation and implicate FAM136A in mitochondrial proteostasis. Their findings suggest a mitochondrial contribution to...
www.cell.com
July 28, 2025 at 5:40 AM
Reposted by MitoMavericks
mitoscientist.bsky.social
Join us in India for an exciting meeting on mitochondria in health, disease, and aging, Oct 9 to 11, 2025, at Manipal University, Manipal.
August 5, 2025 at 10:59 PM
Reposted by MitoMavericks
cvasilescu.bsky.social
Structural basis for promoter recognition and transcription factor binding and release in human mitochondria - ScienceDirect
www.sciencedirect.com/science/arti...
Structural basis for promoter recognition and transcription factor binding and release in human mitochondria
Transcription in human mitochondria is driven by a core apparatus consisting of a Pol A family RNA polymerase (mtRNAP), the initiation factors TFAM an…
www.sciencedirect.com
August 3, 2025 at 7:39 AM
Reposted by MitoMavericks
cvasilescu.bsky.social
Oligomer-based functions of mitochondrial porin | Nature Communications
www.nature.com/articles/s41...
Oligomer-based functions of mitochondrial porin - Nature Communications
Cryo-EM structure of yeast Por1 hexamer reveals functions beyond metabolite and ion transport, including regulation of protein import via Tom22, maintaining lipid composition through scramblase activi...
www.nature.com
August 3, 2025 at 7:37 AM
Reposted by MitoMavericks
cvasilescu.bsky.social
Wonderful selection of papers on #MitochondrialDisease from #week31!
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social

A few highlights below, many more inside!
www.nature.com/articles/s42...
2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction - Nature Metabolism
CLPP-deficiency-driven mitochondrial dysfunction in brown adipose tissue leads to the accumulation of d-2-hydroxyglutarate, in turn promoting lipid-droplet enlargement by altering gene expression and ...
www.nature.com
August 3, 2025 at 7:31 AM
Reposted by MitoMavericks
cvasilescu.bsky.social
#MitochondrialDisease collection of papers from #week30! 📚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social

Mitochondrial Donation in a Reproductive Care Pathway for mtDNA Disease | New England Journal of Medicine
www.nejm.org/doi/10.1056/...
Mitochondrial Donation in a Reproductive Care Pathway for mtDNA Disease | NEJM
Pathogenic variants in mitochondrial DNA (mtDNA) are a common cause of severe, often fatal, inherited metabolic disease. A reproductive care pathway was implemented to provide women carrying pathog...
www.nejm.org
July 27, 2025 at 11:01 AM
Reposted by MitoMavericks
cvasilescu.bsky.social
#MitochondrialDisease selection of papers from #week29! 📚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social

Mitochondrial Donation and Preimplantation Genetic Testing for mtDNA Disease
www.nejm.org/doi/full/10....
Mitochondrial Donation and Preimplantation Genetic Testing for mtDNA Disease | NEJM
Children born to women who carry pathogenic variants in mitochondrial DNA (mtDNA) are at risk for a range of clinical syndromes collectively known as mtDNA disease. Mitochondrial donation by pronuc...
www.nejm.org
July 20, 2025 at 11:30 AM
Reposted by MitoMavericks
cvasilescu.bsky.social
MitoRUSH as a tool to study the efficiency of mitochondrial import in complex I-deficient cells | Journal of Cell Science | The Company of Biologists
journals.biologists.com/jcs/article-...
MitoRUSH as a tool to study the efficiency of mitochondrial import in complex I-deficient cells
Summary: Two assays are used to assess protein import into mitochondria in intact mammalian cells, demonstrating that it is affected in cells with dysfunctional respiratory complex I.
journals.biologists.com
July 13, 2025 at 4:23 PM
Reposted by MitoMavericks
cvasilescu.bsky.social
A superb #MitochondrialDisease selection of papers from #week28 !
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social

Shi et al, Coenzyme Q headgroup intermediates can ameliorate a mitochondrial encephalopathy
www.nature.com/articles/s41...
Coenzyme Q headgroup intermediates can ameliorate a mitochondrial encephalopathy - Nature
Decreased brain coenzyme Q10 levels cause encephalopathy and are associated with neurodegeneration; supplementation with 4-HMA or 4-HB restores coenzyme Q10 synthesis in mice and humans with HPDL vari...
www.nature.com
July 13, 2025 at 4:01 PM