Brian Irving, PhD
mitophys.bsky.social
Brian Irving, PhD
@mitophys.bsky.social
Professor of Exercise Physiology, mitochondria physiology, muscle physiology, metabolism, aging, and cardiometabolic disease. Views are my own.
Pinned
In this review, we describe the pathophysiology of sarcopenia and cachexia, explore their definitions in the context of geriatric oncology, and examine assessment methods used in clinical practice. Great job Makis.

link.springer.com/article/10.1...
Sarcopenia and Cachexia in Older Patients with Cancer: Pathophysiology, Diagnosis, Impact on Outcomes, and Management Strategies - Drugs & Aging
Sarcopenia and cachexia are two common and overlapping but distinct muscle wasting syndromes that predict adverse outcomes and undermine quality of life among older adults with cancer. Despite their prognostic value and negative effects on older patients’ well-being, sarcopenia and cachexia are not routinely or adequately assessed and managed in clinical oncology practice. However, efforts to recognize and manage sarcopenia and cachexia at diagnosis and during follow-up may have beneficial effects on muscle mass, physical function, and quality of life among older adults with cancer, although evidence on long-term clinical outcomes in response to targeted interventions has yet to be established. This comprehensive review attempts to (i) delineate the differences in the pathophysiology and clinical manifestations between sarcopenia and cachexia, (ii) clarify how sarcopenia and cachexia are defined in the geriatric oncology literature, (iii) describe methods for assessing sarcopenia and cachexia in clinical practice, (iv) review the prognostic value of sarcopenia and cachexia among older patients, particularly those undergoing systemic cancer treatment, and (v) discuss evidence-based strategies aimed at managing sarcopenia and cachexia for older adults with cancer.
link.springer.com
In this review, we describe the pathophysiology of sarcopenia and cachexia, explore their definitions in the context of geriatric oncology, and examine assessment methods used in clinical practice. Great job Makis.

link.springer.com/article/10.1...
Sarcopenia and Cachexia in Older Patients with Cancer: Pathophysiology, Diagnosis, Impact on Outcomes, and Management Strategies - Drugs & Aging
Sarcopenia and cachexia are two common and overlapping but distinct muscle wasting syndromes that predict adverse outcomes and undermine quality of life among older adults with cancer. Despite their prognostic value and negative effects on older patients’ well-being, sarcopenia and cachexia are not routinely or adequately assessed and managed in clinical oncology practice. However, efforts to recognize and manage sarcopenia and cachexia at diagnosis and during follow-up may have beneficial effects on muscle mass, physical function, and quality of life among older adults with cancer, although evidence on long-term clinical outcomes in response to targeted interventions has yet to be established. This comprehensive review attempts to (i) delineate the differences in the pathophysiology and clinical manifestations between sarcopenia and cachexia, (ii) clarify how sarcopenia and cachexia are defined in the geriatric oncology literature, (iii) describe methods for assessing sarcopenia and cachexia in clinical practice, (iv) review the prognostic value of sarcopenia and cachexia among older patients, particularly those undergoing systemic cancer treatment, and (v) discuss evidence-based strategies aimed at managing sarcopenia and cachexia for older adults with cancer.
link.springer.com
October 9, 2025 at 1:27 AM
Reposted by Brian Irving, PhD
Exposure of resting #Tcells to physiologically relevant #lactate concentrations is shown to increase #mitochondria #respiration of resting T-cells in culture, suggesting that vigorous #exercise may prime immune cell function.
doi.org/10.14814/phy...
#Physiology #ImmuneSystem
doi.org
July 25, 2025 at 9:02 AM
Lactate homeostasis is maintained through regulation of glycolysis and lipolysis: Cell Metabolism www.cell.com/cell-metabol...
Lactate homeostasis is maintained through regulation of glycolysis and lipolysis
Lactate elevations are a hallmark of human disease, but the mechanisms regulating lactate levels remain poorly understood. Here, Lee et al. elucidate the mechanisms of lactate homeostasis. These invol...
www.cell.com
March 7, 2025 at 2:26 PM
Reposted by Brian Irving, PhD
I recently stumbled upon the gt package for R programming, a real game-changer for anyone looking to elevate their table game!

Developed by Richard Iannone and colleagues, it simplifies table creation.
Package documentation: https://gt.rstudio.com/

More: http://eepurl.com/gH6myT

#data #statistics
January 16, 2025 at 10:38 AM
Reposted by Brian Irving, PhD
Open-rank faculty position with focus on healthy aging/lifespan available in the Department of Kinesiology @UWMadison!!!

jobs.wisc.edu/jobs/kinesio...
Kinesiology Faculty - Madison, Wisconsin, United States
Job Summary: The Department of Kinesiology at the University of Wisconsin-Madison is seeking outstanding candidates for an open rank tenure-track faculty position. Desirable candidates should be abl...
jobs.wisc.edu
December 11, 2024 at 11:36 PM
Guillaume, James, and John did a great job putting this together. I am glad to have helped.

www.taylorfrancis.com/books/edit/1...
Exercise Immunology | James Turner, Guillaume Spielmann, John Campbell
Exercise immunology is a discipline at the nexus of exercise physiology and immunology that aims to characterise the effects of exercise on the immune system in
www.taylorfrancis.com
December 12, 2024 at 2:41 AM
Super excited to have installed the Technavance Bilateral Knee Extension Ergometer. Bengt Saltin would be proud. @lsukinesiology.bsky.social
December 5, 2024 at 4:39 PM
Reposted by Brian Irving, PhD
This will enhance our understanding of how exercise improves lipolytic function to bring about beneficial effects, offering new insights into potential therapeutic avenues for promoting health and alleviating diseases.
www.sciencedirect.com/science/arti...
November 29, 2024 at 3:43 PM
Reposted by Brian Irving, PhD
#Lactate #metabolism and histone lactylation in the central nervous system disorders: impacts and molecular mechanisms
jneuroinflammation.biomedcentral.com/articles/10....
November 29, 2024 at 2:56 PM
Reposted by Brian Irving, PhD
Academics wanting to 'verify' their Bluesky profile as genuine might give an ORCID identifier in their profile and link back to their Bluesky profile from ORCID.

#AcademicSky
November 21, 2024 at 9:13 AM
Reposted by Brian Irving, PhD
Check out our database of 47 POSTDOCTORAL fellowships in cancer/oncology.

For each fellowship, we provide a brief description, link to opportunity, deadline, and eligibility criteria (e.g. citizenship).

Download this database here (Excel file): research.jhu.edu/rdt/funding-...

Good luck!
November 24, 2024 at 2:20 PM
Reposted by Brian Irving, PhD
Mitochondrial pyruvate transport regulates presynaptic metabolism and neurotransmission

www.science.org/doi/10.1126/...
Mitochondrial pyruvate transport regulates presynaptic metabolism and neurotransmission
The brain uses pyruvate as an energy source, and mitochondrial pyruvate metabolism in nerve terminals controls neurotransmission.
www.science.org
November 20, 2024 at 1:31 PM
Reposted by Brian Irving, PhD
Where is the “Mitochondria is the powerhouse of the cell” starter pack
November 19, 2024 at 4:25 PM
Reposted by Brian Irving, PhD
We are recruiting an Assistant Professor with expertise in biotechnology, biosensing, or Ai in the LSU School of Kinesiology.

lsu.wd1.myworkdayjobs.com/LSU/job/H-P-...

If you have any questions please feel free to reach out.
November 15, 2024 at 11:10 PM
Reposted by Brian Irving, PhD
Summiting Mount Everest in #deuterium depleting nutritional #ketosis without supplemental oxygen

👇
www.sciencedirect.com/science/arti...
November 16, 2024 at 11:29 AM
Reposted by Brian Irving, PhD
Impaired branched chain amino acid (BCAA) catabolism during adipocyte differentiation decreases glycolytic flux
www.sciencedirect.com/science/arti...
November 16, 2024 at 11:21 AM
We are recruiting an Assistant Professor with expertise in biotechnology, biosensing, or Ai in the LSU School of Kinesiology.

lsu.wd1.myworkdayjobs.com/LSU/job/H-P-...

If you have any questions please feel free to reach out.
November 15, 2024 at 11:10 PM
Reposted by Brian Irving, PhD
New from Cold Spring Harbor Press. Available in December, 2024, just in time for the holidays! -RJD
November 15, 2024 at 7:06 PM
Reposted by Brian Irving, PhD
People working on #cancermetabolism, #mitochondrialbiology, #metabolism, please reach out! Share this so I can follow who is here! I will share paper on cancer metabolism, but anything else related to mitochondria and metabolism.
a bald man in a blue suit is making a funny face and pointing at something .
ALT: a bald man in a blue suit is making a funny face and pointing at something .
media.tenor.com
November 13, 2024 at 7:24 PM