Michael Gemki
@michigemki.bsky.social
⚗️ | ⚽ | 🏌️♂️ - Organic Synthesis Focused – Driven by Application @fz-juelich.de | ↗️ Make Tetrahedron Great Again.. 😃 | 🇪🇺 😘
Reposted by Michael Gemki
May I recommend this series:
Published annually by Pfizer Merck Takeda and others
Review of synthetic methods to marketed drugs
Great look at the current state of pharma synthesis
Published annually by Pfizer Merck Takeda and others
Review of synthetic methods to marketed drugs
Great look at the current state of pharma synthesis
Synthetic Approaches to the New Drugs Approved during 2023
This review is the next installment of an annual series that discusses the synthetic routes to access 28 small molecule drugs that were approved worldwide in 2023. A brief description of each drug’s m...
pubs.acs.org
November 13, 2025 at 12:58 AM
May I recommend this series:
Published annually by Pfizer Merck Takeda and others
Review of synthetic methods to marketed drugs
Great look at the current state of pharma synthesis
Published annually by Pfizer Merck Takeda and others
Review of synthetic methods to marketed drugs
Great look at the current state of pharma synthesis
Reposted by Michael Gemki
Commercial/lrg scale of API generally avoids glove-box type reactions - this annual review is chock full of “regular” reactions used for scale up
Synthetic Approaches to the New Drugs Approved during 2023
This review is the next installment of an annual series that discusses the synthetic routes to access 28 small molecule drugs that were approved worldwide in 2023. A brief description of each drug’s m...
pubs.acs.org
June 4, 2025 at 9:12 PM
Commercial/lrg scale of API generally avoids glove-box type reactions - this annual review is chock full of “regular” reactions used for scale up
>> are you measuring optical rotations?! 🤔😐😅
March 30, 2025 at 4:13 PM
>> are you measuring optical rotations?! 🤔😐😅
Reposted by Michael Gemki
Next up we’ll have a talk from @stephanhacker2.bsky.social about identifying electrophiles to target amino acids beyond cysteine, including the first probes to globally monitor tryptophans, histidines and arginines ✨
chemrxiv.org/engage/chemr...
chemrxiv.org/engage/chemr...
Profiling the proteome-wide selectivity of diverse electrophiles
Targeted covalent inhibitors are powerful entities in drug discovery, but their application has so far mainly been limited to addressing cysteine residues. The development of cysteine-directed covalen...
chemrxiv.org
March 30, 2025 at 10:10 AM
Next up we’ll have a talk from @stephanhacker2.bsky.social about identifying electrophiles to target amino acids beyond cysteine, including the first probes to globally monitor tryptophans, histidines and arginines ✨
chemrxiv.org/engage/chemr...
chemrxiv.org/engage/chemr...
>> that recently published convergent multigram-synthesis is also quite mind-provoking.... 😉
March 5, 2025 at 6:54 AM
>> that recently published convergent multigram-synthesis is also quite mind-provoking.... 😉
>> could have been a bit more F-18 and C-11 chemistry, but ok.... 😉
January 29, 2025 at 7:23 AM
>> could have been a bit more F-18 and C-11 chemistry, but ok.... 😉
>> Please see some papers from my former supervisor Prof. H.-G. Schmalz, U of Cologne - for instance:
(1) onlinelibrary.wiley.com/doi/10.1002/...
or more recent:
(2) pubs.rsc.org/en/content/a...
cheers!
(1) onlinelibrary.wiley.com/doi/10.1002/...
or more recent:
(2) pubs.rsc.org/en/content/a...
cheers!
Design of an aryne-platform for the synthesis of non-racemic heterocyclic allocolchicinoids
A four-step semisynthetic approach towards a highly versatile allocolchicine-related chiral aryne intermediate starting from naturally occurring colchicine was developed, and some of its synthetic tra...
pubs.rsc.org
January 16, 2025 at 6:10 AM
>> Please see some papers from my former supervisor Prof. H.-G. Schmalz, U of Cologne - for instance:
(1) onlinelibrary.wiley.com/doi/10.1002/...
or more recent:
(2) pubs.rsc.org/en/content/a...
cheers!
(1) onlinelibrary.wiley.com/doi/10.1002/...
or more recent:
(2) pubs.rsc.org/en/content/a...
cheers!