Matan Geron
@mgeron.bsky.social
Postdoc in the Scherrer lab at UNC-Chapel Hill studying pain and opioids
Reposted by Matan Geron
In January, the FDA approved a new non-opioid painkiller. CBP's Grégory Scherrer spoke with @theguardian.com about the new wave of developing non-opioid drugs for pain relief. Read here: www.theguardian.com/science/2025...
Painkillers without the addiction? The new wave of non-opioid pain relief
Pharma firms are developing drugs that avoid the brain’s opioid receptors to minimise the risks of dependence and overdoses, but not all experts are convinced
www.theguardian.com
April 9, 2025 at 6:54 PM
In January, the FDA approved a new non-opioid painkiller. CBP's Grégory Scherrer spoke with @theguardian.com about the new wave of developing non-opioid drugs for pain relief. Read here: www.theguardian.com/science/2025...
Reposted by Matan Geron
A DREADD for the periphery - Nature Methods
Nature Methods - A DREADD for the periphery
www.nature.com
February 11, 2025 at 8:57 PM
Reposted by Matan Geron
Kang et al. present HCAD, a peripherally restricted DREADD based on HCA2, with a chemical actuator that avoids crossing the blood-brain barrier and selectively reduces pain in mice.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Structure-guided design of a peripherally restricted chemogenetic system
Kang et al. present HCAD, a peripherally restricted DREADD based on HCA2, with a chemical actuator that avoids crossing the blood-brain barrier and selectively reduces pain in mice. This system will enable the study of peripheral physiology without affecting the central nervous system.
www.cell.com
January 2, 2025 at 12:47 PM
Kang et al. present HCAD, a peripherally restricted DREADD based on HCA2, with a chemical actuator that avoids crossing the blood-brain barrier and selectively reduces pain in mice.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Matan Geron
New from Rothlab!
www.miragenews.com/gene-therapy...
www.miragenews.com/gene-therapy...
Gene Therapy Breakthrough Targets Peripheral Pain
Pain is meant to be a defense mechanism. It creates a strong sensation to get us to respond to a stimulus and prevent ourselves from further harm
www.miragenews.com
December 17, 2024 at 10:41 PM
New from Rothlab!
www.miragenews.com/gene-therapy...
www.miragenews.com/gene-therapy...
I am glad to share our recent work, now published in Cell! A @zenbrainest.bsky.social and Scherrer lab collaboration developing and validating a new peripherally restricted DREADD system! Great team work with Hye Jin Kang, Brian Krumm, @adrtas.bsky.social, and others
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
Structure-guided design of a peripherally restricted chemogenetic system
Kang et al. present HCAD, a peripherally restricted DREADD based on HCA2, with a chemical actuator that avoids crossing the blood-brain barrier and selectively reduces pain in mice. This system will enable the study of peripheral physiology without affecting the central nervous system.
www.cell.com
December 7, 2024 at 1:41 AM
I am glad to share our recent work, now published in Cell! A @zenbrainest.bsky.social and Scherrer lab collaboration developing and validating a new peripherally restricted DREADD system! Great team work with Hye Jin Kang, Brian Krumm, @adrtas.bsky.social, and others
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
Reposted by Matan Geron
New paper from the lab:
Structure-guided design of a peripherally restricted chemogenetic system
10.1016/j.cell.2024.11.001
Structure-guided design of a peripherally restricted chemogenetic system
10.1016/j.cell.2024.11.001
December 3, 2024 at 5:54 PM
New paper from the lab:
Structure-guided design of a peripherally restricted chemogenetic system
10.1016/j.cell.2024.11.001
Structure-guided design of a peripherally restricted chemogenetic system
10.1016/j.cell.2024.11.001
Reposted by Matan Geron
I started (at @katesadlerphd.bsky.social's suggestion, thanks Kate for pushing me) a pain neuroscience and pain research starter pack. I am sure I have missed many people so if I missed you, I am sorry, but please just ask me to add you in the thread below and I will do that. go.bsky.app/KboKNhg
November 18, 2024 at 4:58 PM
I started (at @katesadlerphd.bsky.social's suggestion, thanks Kate for pushing me) a pain neuroscience and pain research starter pack. I am sure I have missed many people so if I missed you, I am sorry, but please just ask me to add you in the thread below and I will do that. go.bsky.app/KboKNhg