Harvard Molecular Metabolism
@met-hsph.bsky.social
Researching the interplay between factors underlying metabolic health and disease, including diet, age, environment, and genetics, for the prevention and treatment of widespread chronic diseases. https://hsph.harvard.edu/department/molecular-metabolism/
Melanoma cells that spread to lymph nodes depend on FSP1 to survive, revealing a new metabolic vulnerability. New study in Nature by @mariopalma.bsky.social @ubellackerlab.bsky.social and colleagues shows that blocking FSP1 triggers ferroptosis and suppresses tumor growth in lymph node metastases.
Lymph node environment drives FSP1 targetability in metastasizing melanoma - Nature
Targeting FSP1 in lymph nodes has considerable potential for blocking melanoma progression.
www.nature.com
November 5, 2025 at 5:28 PM
Melanoma cells that spread to lymph nodes depend on FSP1 to survive, revealing a new metabolic vulnerability. New study in Nature by @mariopalma.bsky.social @ubellackerlab.bsky.social and colleagues shows that blocking FSP1 triggers ferroptosis and suppresses tumor growth in lymph node metastases.
New Molecular Metabolism study from the Biddinger Lab finds diabetes gene TCF7L2 is crucial for hepatic zonation and glutamine metabolism. Liver-specific Tcf7l2 knockout mice exhibit metabolic reprogramming, and decreased glutamine in humans with the rs7903146 variant. #BiddingerLab
hsph.me/Tcf7l2
hsph.me/Tcf7l2
The diabetes gene Tcf7l2 organizes gene expression in the liver and regulates amino acid metabolism
Though Tcf7l2 harbors the strongest genetic association with diabetes identified thus far, how it promotes metabolic disease remains unclear. Our aim …
www.sciencedirect.com
August 18, 2025 at 6:44 PM
New Molecular Metabolism study from the Biddinger Lab finds diabetes gene TCF7L2 is crucial for hepatic zonation and glutamine metabolism. Liver-specific Tcf7l2 knockout mice exhibit metabolic reprogramming, and decreased glutamine in humans with the rs7903146 variant. #BiddingerLab
hsph.me/Tcf7l2
hsph.me/Tcf7l2
Ferroptosis-targeting therapies in cancer have yet to make it to the clinic. New review published today in Nature Cancer by @ubellackerlab.bsky.social and Scott Dixon of Stanford share hurdles and ideas for future strategies to bring these therapies closer to the clinic. Check it out
rdcu.be/eBbqV
rdcu.be/eBbqV
Prospects for ferroptosis therapies in cancer
Nature Cancer - Ubellacker and Dixon summarize the latest discoveries on ferroptosis in cancer, covering the molecular and cellular pathways underlying sensitivity and resistance to this type of...
rdcu.be
August 18, 2025 at 2:01 PM
Ferroptosis-targeting therapies in cancer have yet to make it to the clinic. New review published today in Nature Cancer by @ubellackerlab.bsky.social and Scott Dixon of Stanford share hurdles and ideas for future strategies to bring these therapies closer to the clinic. Check it out
rdcu.be/eBbqV
rdcu.be/eBbqV
Jessalyn Ubellacker @ubellackerlab.bsky.social was honored with a FASEB Journal Early Career Researcher Award at the first FASEB Ferroptosis, Oxidative Stress, and Lipid Metabolism meeting, co-organized by James Olzmann @olzmannlab.bsky.social and Scott Dixon, to support early career researchers.
August 8, 2025 at 6:02 PM
Jessalyn Ubellacker @ubellackerlab.bsky.social was honored with a FASEB Journal Early Career Researcher Award at the first FASEB Ferroptosis, Oxidative Stress, and Lipid Metabolism meeting, co-organized by James Olzmann @olzmannlab.bsky.social and Scott Dixon, to support early career researchers.
Reposted by Harvard Molecular Metabolism
🚨The final programme for #FusionAging25 is now live
⬇️Check out our website to view the short talks that will be joining our invited speaker line-up - it is shaping up to be a fantastic 4 days!
🗓️Final Poster & Reg Deadline: 07 Aug 2025
🔗 bit.ly/3FR0Z3E
#FusionAgingResearch
⬇️Check out our website to view the short talks that will be joining our invited speaker line-up - it is shaping up to be a fantastic 4 days!
🗓️Final Poster & Reg Deadline: 07 Aug 2025
🔗 bit.ly/3FR0Z3E
#FusionAgingResearch
June 16, 2025 at 10:34 AM
🚨The final programme for #FusionAging25 is now live
⬇️Check out our website to view the short talks that will be joining our invited speaker line-up - it is shaping up to be a fantastic 4 days!
🗓️Final Poster & Reg Deadline: 07 Aug 2025
🔗 bit.ly/3FR0Z3E
#FusionAgingResearch
⬇️Check out our website to view the short talks that will be joining our invited speaker line-up - it is shaping up to be a fantastic 4 days!
🗓️Final Poster & Reg Deadline: 07 Aug 2025
🔗 bit.ly/3FR0Z3E
#FusionAgingResearch
Reposted by Harvard Molecular Metabolism
Just two of thousands of such stories. substack.com/home/post/p-...
I Was Just About To When My Grant Was Cut.
We ask researchers to send us their stories of what they were working on when their research grant was cut. Today, we share the stories of Tashara and Brendan.
substack.com
July 29, 2025 at 2:15 PM
Just two of thousands of such stories. substack.com/home/post/p-...
New study in @cp-devcell.bsky.social from the @bdmanning.bsky.social Lab.
@yannphd.bsky.social and team define the physiological role of AKT-mediated phosphorylation of TSC2 in regulating mTORC1 signaling. www.cell.com/developmenta...
@yannphd.bsky.social and team define the physiological role of AKT-mediated phosphorylation of TSC2 in regulating mTORC1 signaling. www.cell.com/developmenta...
AKT-mediated phosphorylation of TSC2 controls stimulus- and tissue-specific mTORC1 signaling and organ growth
Cormerais et al. describe the TSC2-5A mouse model lacking the five phosphorylation
sites on TSC2 through which AKT activates mTORC1. The TSC2-5A mice are developmentally
normal but show reduced body- ...
www.cell.com
June 10, 2025 at 6:59 PM
New study in @cp-devcell.bsky.social from the @bdmanning.bsky.social Lab.
@yannphd.bsky.social and team define the physiological role of AKT-mediated phosphorylation of TSC2 in regulating mTORC1 signaling. www.cell.com/developmenta...
@yannphd.bsky.social and team define the physiological role of AKT-mediated phosphorylation of TSC2 in regulating mTORC1 signaling. www.cell.com/developmenta...
For 25 years, Dr. Manning & his lab have advanced TSC research, uncovering how the mTOR pathway shapes cell growth—and unlocking insights across cancer, diabetes & more. Research that until recently was supported by taxpayers through the NIH. #TSC #science #ResearchMatters
Brendan Manning: Unraveling the cell’s inner workings
For Brendan Manning, PhD, today’s advances in basic science are the stepping stones to the next breakthrough in treating tuberous sclerosis complex (TSC). Manning has spent the last 25 years researchi...
www.tscalliance.org
May 30, 2025 at 4:24 PM
For 25 years, Dr. Manning & his lab have advanced TSC research, uncovering how the mTOR pathway shapes cell growth—and unlocking insights across cancer, diabetes & more. Research that until recently was supported by taxpayers through the NIH. #TSC #science #ResearchMatters
From @hsph.harvard.edu Hotamışlıgil Lab, @renata-goncalves.bsky.social identifies an important mechanism that leads to liver dysfunction in obesity—defective coenzyme Q metabolism. This finding paves the way for more targeted diabetes & metabolic disease treatments. Read more:
hsph.me/mitoT2D
hsph.me/mitoT2D
Newly discovered mechanism of mitochondrial dysfunction in obesity may drive insulin resistance and type 2 diabetes | Harvard T.H. Chan School of Public Health
A newly discovered mechanism that leads to liver dysfunction may be a key factor in type 2 diabetes and other metabolic disorders in individuals with obesity, according to a new study led by Harvard C...
hsph.harvard.edu
May 28, 2025 at 7:51 PM
From @hsph.harvard.edu Hotamışlıgil Lab, @renata-goncalves.bsky.social identifies an important mechanism that leads to liver dysfunction in obesity—defective coenzyme Q metabolism. This finding paves the way for more targeted diabetes & metabolic disease treatments. Read more:
hsph.me/mitoT2D
hsph.me/mitoT2D
Reposted by Harvard Molecular Metabolism
🗓️ Join us Friday, Apr 25 for a #seminar with Brendan Manning — Professor and Chair of Molecular Metabolism at Harvard T.H. Chan School of Public Health.
He'll explore the TSC-mTOR pathway in growth and metabolism. Don’t miss it! @bdmanning.bsky.social @met-hsph.bsky.social @mario-pende.bsky.social
He'll explore the TSC-mTOR pathway in growth and metabolism. Don’t miss it! @bdmanning.bsky.social @met-hsph.bsky.social @mario-pende.bsky.social
April 18, 2025 at 8:08 AM
🗓️ Join us Friday, Apr 25 for a #seminar with Brendan Manning — Professor and Chair of Molecular Metabolism at Harvard T.H. Chan School of Public Health.
He'll explore the TSC-mTOR pathway in growth and metabolism. Don’t miss it! @bdmanning.bsky.social @met-hsph.bsky.social @mario-pende.bsky.social
He'll explore the TSC-mTOR pathway in growth and metabolism. Don’t miss it! @bdmanning.bsky.social @met-hsph.bsky.social @mario-pende.bsky.social
Reposted by Harvard Molecular Metabolism
A reminder that for next month’s BCDI in place of our regular discussion, we encourage you to attend the Cutter Distinguished Lecture @met-hsph.bsky.social by the great Scott Dixon!
See you there: Monday May 12, 2025, Kresge Building at HSPH, G1 auditorium, 12:00-1:00pm
See you there: Monday May 12, 2025, Kresge Building at HSPH, G1 auditorium, 12:00-1:00pm
April 18, 2025 at 3:13 PM
A reminder that for next month’s BCDI in place of our regular discussion, we encourage you to attend the Cutter Distinguished Lecture @met-hsph.bsky.social by the great Scott Dixon!
See you there: Monday May 12, 2025, Kresge Building at HSPH, G1 auditorium, 12:00-1:00pm
See you there: Monday May 12, 2025, Kresge Building at HSPH, G1 auditorium, 12:00-1:00pm
Exciting findings from Bo Yuan, PhD of the @tonyhui.bsky.social Lab: a whole-body quantitative flux model of energy metabolism was built, revealing surprising features of energy metabolism in both normal physiology and obesity. Great collaboration with the Hotamışlıgil Lab!
An organism-level quantitative flux model of energy metabolism in mice
Mammalian tissues feed on nutrients in the blood circulation. At the organism level, mammalian energy metabolism is comprised of the oxidation, storag…
www.sciencedirect.com
February 24, 2025 at 9:31 PM
Exciting findings from Bo Yuan, PhD of the @tonyhui.bsky.social Lab: a whole-body quantitative flux model of energy metabolism was built, revealing surprising features of energy metabolism in both normal physiology and obesity. Great collaboration with the Hotamışlıgil Lab!
Publication in @embomolmed.org identifies FABP4 as a key host factor regulating SARS-CoV-2 replication, inflammation and lung damage. Providing a promising treatment candidate. #COVID19Research #Metabolism #HotamisligilLab
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
February 7, 2025 at 7:25 PM
Publication in @embomolmed.org identifies FABP4 as a key host factor regulating SARS-CoV-2 replication, inflammation and lung damage. Providing a promising treatment candidate. #COVID19Research #Metabolism #HotamisligilLab
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
@ubellackerlab.bsky.social in Nature Protocols, details new protocol for collecting lymph and tumor-draining lymph from mouse models of cancer metastasis. This method enables multiomic profiling of lymph-derived cancer cells, revealing the impact of the lymphatic environment on cancer progression.
Lymphatic collection and cell isolation from mouse models for multiomic profiling - Nature Protocols
An approach to collect lymph drained from the primary tumor in mice enables the downstream characterization of the samples using metabolomics, lipidomics and flow cytometry.
www.nature.com
January 16, 2025 at 3:51 PM
@ubellackerlab.bsky.social in Nature Protocols, details new protocol for collecting lymph and tumor-draining lymph from mouse models of cancer metastasis. This method enables multiomic profiling of lymph-derived cancer cells, revealing the impact of the lymphatic environment on cancer progression.