Meru Sadhu
@merusadhu.bsky.social
Host pathogen interactions, high-throughput genetics, and yeast! Here to learn about and share cool science.
Reposted by Meru Sadhu
Come join us in beautiful Britanny, France in May 2026 for a workshop that I am organizing with @lucievirevolte.bsky.social and @psudmant.bsky.social on Rapid host adaptations to infections:
sites.google.com/berkeley.edu...
sites.google.com/berkeley.edu...
October 23, 2025 at 1:20 PM
Come join us in beautiful Britanny, France in May 2026 for a workshop that I am organizing with @lucievirevolte.bsky.social and @psudmant.bsky.social on Rapid host adaptations to infections:
sites.google.com/berkeley.edu...
sites.google.com/berkeley.edu...
Reposted by Meru Sadhu
Happy to share the final story from my thesis, demonstrating that the common ancestor of all terrestrial fungi had zymocin-like killer plasmids, a toxin system found in some budding yeasts. Come with me on an all-too-familiar, database dumpster-diving journey (1/10)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Zymocin-like killer plasmids were present in the common ancestor of terrestrial fungi
Some budding yeasts secrete killer toxins made by linear dsDNA plasmids located in the cytosol. The best-known example is the Kluyveromyces lactis toxin zymocin, which is encoded by a 9-kb killer plas...
www.biorxiv.org
October 21, 2025 at 7:48 PM
Happy to share the final story from my thesis, demonstrating that the common ancestor of all terrestrial fungi had zymocin-like killer plasmids, a toxin system found in some budding yeasts. Come with me on an all-too-familiar, database dumpster-diving journey (1/10)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Meru Sadhu
✨ Latest exciting story of the group in @nature.com. Here, we go beyond SNPs and built a species-wide atlas of genetic variants in yeast. With >1,000 near T2T genomes, we show how large genomic variations affect trait diversity.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
From genotype to phenotype with 1,086 near telomere-to-telomere yeast genomes - Nature
A newly compiled atlas of species-wide structural variants and gene-based and graph pangenomes derived from highly complete assemblies of genomes from 1,086 natural isolates enable integrative genome-...
www.nature.com
October 16, 2025 at 7:49 AM
✨ Latest exciting story of the group in @nature.com. Here, we go beyond SNPs and built a species-wide atlas of genetic variants in yeast. With >1,000 near T2T genomes, we show how large genomic variations affect trait diversity.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Just imagining research talks in antiquity.
EUCLID: …thus, there does not exist a rational number whose square is equal to 2.
HIPPOCRATES: [grumbling] I fail to see the clinical relevance of any of this
EUCLID: …thus, there does not exist a rational number whose square is equal to 2.
HIPPOCRATES: [grumbling] I fail to see the clinical relevance of any of this
September 26, 2025 at 1:01 PM
Just imagining research talks in antiquity.
EUCLID: …thus, there does not exist a rational number whose square is equal to 2.
HIPPOCRATES: [grumbling] I fail to see the clinical relevance of any of this
EUCLID: …thus, there does not exist a rational number whose square is equal to 2.
HIPPOCRATES: [grumbling] I fail to see the clinical relevance of any of this
Final version of our paper out now on how high-throughput methods can be useful for answering everyday “low-throughput” genetic questions!
New paper in #G3journal from @merusadhu.bsky.social and colleagues presents a barcode-based high-throughput method that can track large numbers of independent replicates of a small number of combinatorial genotypes. buff.ly/Q0qgBQz
September 11, 2025 at 3:08 AM
Final version of our paper out now on how high-throughput methods can be useful for answering everyday “low-throughput” genetic questions!
Reposted by Meru Sadhu
Now out officially, with the entire kit on @addgene.bsky.social. Great collaboration with @merusadhu.bsky.social, with more to come.
New #CRISPR resource in #G3journal: A set of plasmids expressing Cas9-EcRT allows for co-transformation with the gRNA-repair template plasmid in a single step while containing different antibiotic or auxotrophic markers for gene editing in #yeast. buff.ly/TC8ECCV
August 20, 2025 at 12:51 PM
Now out officially, with the entire kit on @addgene.bsky.social. Great collaboration with @merusadhu.bsky.social, with more to come.
Reposted by Meru Sadhu
Kamilla Laidlaw, Hatwan Nadir, Chris MacDonald @yorkyeast.bsky.social and team @biologyatyork.bsky.social discover that killer toxin K28 resistance in yeast relies on COG complex-mediated trafficking of Ktd1.
journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
July 21, 2025 at 12:25 PM
Kamilla Laidlaw, Hatwan Nadir, Chris MacDonald @yorkyeast.bsky.social and team @biologyatyork.bsky.social discover that killer toxin K28 resistance in yeast relies on COG complex-mediated trafficking of Ktd1.
journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
Article: journals.biologists.com/jcs/article/...
New paper from my lab! We describe our idea that high-throughput pooled experimental methods – typically used to test thousands of hypotheses at once – also have huge potential to help in “everyday” experiments testing one or a few focused hypotheses. Why? Two reasons: doi.org/10.1093/g3jo...
Validate User
doi.org
July 14, 2025 at 3:18 PM
New paper from my lab! We describe our idea that high-throughput pooled experimental methods – typically used to test thousands of hypotheses at once – also have huge potential to help in “everyday” experiments testing one or a few focused hypotheses. Why? Two reasons: doi.org/10.1093/g3jo...