This work complies with all relevant ethical regulations. A full list of the ethics boards that approved the study protocols is provided at the end of this section. Samples FinnGen is a large national genetic resource (N = 520,210; release...

Analysis of the longest-lived mammal, the bowhead whale, reveals an improved ability to repair DNA breaks, mediated by high levels of cold-inducible RNA-binding protein.   

We adopted an unbiased approach to identify driving transcription factors in PDAC and performed chromatin immunoprecipitation sequencing (ChIP–seq) of the active enhancer mark H3K27Ac on surplus tissue obtained after the resection of primary PDAC (Whipple surgical samples). We identified all...

Efficient DNA repair might make possible the longevity of naked mole-rats. However, whether they have distinctive mechanisms to optimize functions of DNA repair suppressors is unclear. We find that na...

CRISPR-based epigenetic editing is used in a cell-type-specific, locus-restricted and temporally controllable manner in the adult mouse brain to modulate memory expression.

scMicro-C is a new method that provides high-resolution maps of the 3D genome. scMicro-C identifies structures called ‘promoter stripes’, which link a gene promoter to multiple downstream enhancers.