Josh Mendell
@mendell-lab.bsky.social
Scientist in Dept of Mol Bio, UTSW/HHMI, studying post-transcriptional regulation & noncoding RNAs. Opinions are my own and do not reflect those of my employer.
https://labs.utsouthwestern.edu/mendell-lab
https://www.hhmi.org/scientists/joshua-t-mendell
https://labs.utsouthwestern.edu/mendell-lab
https://www.hhmi.org/scientists/joshua-t-mendell
Congratulations to Kate, Hari, and all authors!
I am pleased to present a new paper from my lab led by Hari Shankar Sunil showing that the transmembrane serine protease TMPRSS11B promotes an acidified tumor microenvironment and immune suppression in squamous lung cancer, OUT NOW in EMBO Reports👇:
embopress.org/doi/full/10....
embopress.org/doi/full/10....
November 11, 2025 at 10:39 PM
Congratulations to Kate, Hari, and all authors!
Regulated decay of microRNAs plays a critical role in controlling body size in mammals! Check out our new paper in @genesdev.bsky.social and see thread previously posted with our pre-print 👇 for more info. Congrats to Collette LaVigne, Jaeil Han, and all authors!
genesdev.cshlp.org/cgi/content/...
genesdev.cshlp.org/cgi/content/...
November 10, 2025 at 5:40 PM
Regulated decay of microRNAs plays a critical role in controlling body size in mammals! Check out our new paper in @genesdev.bsky.social and see thread previously posted with our pre-print 👇 for more info. Congrats to Collette LaVigne, Jaeil Han, and all authors!
genesdev.cshlp.org/cgi/content/...
genesdev.cshlp.org/cgi/content/...
Colliding ribosomes are potent signals of cellular stress. But do cells use ‘programmed’ ribosome collisions to regulate gene expression? I’m excited to present a new story from my lab led by Frederick Rehfeld(@fred-rehfeld.bsky.social) which revealed that the answer is YES! Read on to find out how👇
Oxidative stress sensing by the translation elongation machinery promotes production of detoxifying selenoproteins
Selenocysteine, incorporated into polypeptides at recoded termination codons, plays an essential role in redox biology. Using GPX1 and GPX4, selenoenzymes that mitigate oxidative stress, as reporters,...
www.biorxiv.org
October 14, 2025 at 10:28 PM
Colliding ribosomes are potent signals of cellular stress. But do cells use ‘programmed’ ribosome collisions to regulate gene expression? I’m excited to present a new story from my lab led by Frederick Rehfeld(@fred-rehfeld.bsky.social) which revealed that the answer is YES! Read on to find out how👇
Congratulations @kateodonnell-lab.bsky.social and Shayna!
This is my first post here. The past few months have been challenging for science, but I enjoy learning about others' work here and wanted to share our latest study. Congrats to postdoc Shayna Thomas-Jardin on her outstanding work published in Cancer Research @theaacr.bsky.social
July 17, 2025 at 9:51 PM
Congratulations @kateodonnell-lab.bsky.social and Shayna!
Reposted by Josh Mendell
#Worm25 Congratulations to Jacob (Ortega) for the Sydney Brenner thesis award!!! Truly a spectacular young scientist! Keep an eye out for him!!
Jacob is a postdoc in Josh Mendell’s lab at UTSW right now.
Jacob is a postdoc in Josh Mendell’s lab at UTSW right now.
June 29, 2025 at 3:32 AM
#Worm25 Congratulations to Jacob (Ortega) for the Sydney Brenner thesis award!!! Truly a spectacular young scientist! Keep an eye out for him!!
Jacob is a postdoc in Josh Mendell’s lab at UTSW right now.
Jacob is a postdoc in Josh Mendell’s lab at UTSW right now.
I am pleased to present our latest pre-print describing our identification of the long-sought triggers for target-directed microRNA degradation (TDMD) of miR-322 and miR-503, work led by Collette LaVigne and Jaeil Han. For more info, read on! 👇
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Plagl1 and Lrrc58 control mammalian body size by triggering target-directed microRNA degradation of miR-322 and miR-503
Precise control of microRNA (miRNA) expression is critical during development. An important mechanism of miRNA regulation is target-directed microRNA degradation (TDMD), a pathway in which the binding...
www.biorxiv.org
July 2, 2025 at 4:17 PM
I am pleased to present our latest pre-print describing our identification of the long-sought triggers for target-directed microRNA degradation (TDMD) of miR-322 and miR-503, work led by Collette LaVigne and Jaeil Han. For more info, read on! 👇
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
It's difficult to focus on science with everything going on, but I still enjoy hearing about other people's work here, so I want to continue sharing ours. Congrats to postdoc Jong-Sun Lee for his outstanding work published in @cp-molcell.bsky.social! Details in thread👇
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
An ultraconserved snoRNA-like element in long noncoding RNA CRNDE promotes ribosome biogenesis and cell proliferation
Cancer cells frequently enhance ribosome production to support rapid growth. Here,
Lee et al. demonstrate that an isoform of lncRNA CRNDE containing an ultraconserved
element (CRNDEUCE) promotes 60S r...
www.cell.com
April 3, 2025 at 4:47 PM
It's difficult to focus on science with everything going on, but I still enjoy hearing about other people's work here, so I want to continue sharing ours. Congrats to postdoc Jong-Sun Lee for his outstanding work published in @cp-molcell.bsky.social! Details in thread👇
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Reposted by Josh Mendell
A nice journal club intro by Amy McDermott at PNAS to the excellent paper from @mendell-lab.bsky.social and colleagues #RNAsky #RNAbiology www.pnas.org/post/journal...
A new role for transfer RNA in protein synthesis
Translation entails ribosomes reading a gene’s messenger RNA transcript to generate a protein. Image credit: ART-ur/ Shutterstock.
www.pnas.org
December 6, 2024 at 11:29 PM
A nice journal club intro by Amy McDermott at PNAS to the excellent paper from @mendell-lab.bsky.social and colleagues #RNAsky #RNAbiology www.pnas.org/post/journal...
Great thread on our paper from Jan👇
Our latest paper, a fantastic collaboration with the Mendell Lab, is out. Great work by Xiaoqiang Zhu and Victor Cruz. We uncover how tRNA structural features in the ribosomal P-site modulate co-translational mRNA decay by the CCR4-NOT complex. #RNAsky #RNAbiology #translation #ribosome #cryoEM 1/5
www.science.org
November 22, 2024 at 6:39 PM
Great thread on our paper from Jan👇
I’m thrilled to share a collaborative story from @Mendell_lab and Jan Erzberger labs, led by postdoc extraordinaire Xiaoqiang Zhu. We showed that in addition to their canonical decoding function, tRNAs play a key role in regulating mRNA stability during translation!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Specific tRNAs promote mRNA decay by recruiting the CCR4-NOT complex to translating ribosomes
The CCR4-NOT complex is a major regulator of eukaryotic messenger RNA (mRNA) stability. Slow decoding during translation promotes association of CCR4-NOT with ribosomes, accelerating mRNA degradation....
www.science.org
November 22, 2024 at 6:09 PM
I’m thrilled to share a collaborative story from @Mendell_lab and Jan Erzberger labs, led by postdoc extraordinaire Xiaoqiang Zhu. We showed that in addition to their canonical decoding function, tRNAs play a key role in regulating mRNA stability during translation!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Happy to join you all over here at this better place! I'm excited to share a new paper with this community! 👇
November 22, 2024 at 6:08 PM
Happy to join you all over here at this better place! I'm excited to share a new paper with this community! 👇