Indeed, molecular dynamics simulations show that SND3 disrupts the lipid bilayer and promotes lipid scrambling via its membrane-embedded hydrophilic groove, suggesting that SND3 is a membrane insertase with a novel fold.

Proud to share our first lab pre-print: “SND3 is the membrane insertase within a fungal multipass translocon” where @tzujingyang.bsky.social solved the structure of a ribosome-associated SND3-translocon complex involved in ER membrane protein insertion ➡️ doi.org/10.1101/2025...