Sigolène Meilhac
@meilhacsigolene.bsky.social
Heart Morphogenesis laboratory
Developmental biology, Congenital heart defects, Left-right asymmetry, Heterotaxy
@Institut Pasteur, Institut Imagine, Inserm, UPC - Paris
Developmental biology, Congenital heart defects, Left-right asymmetry, Heterotaxy
@Institut Pasteur, Institut Imagine, Inserm, UPC - Paris
We uncover that the caudal splanchnic mesoderm (in green) acts as a midline anchor of the heart tube. In Vangl2 and Shroom3 mutants, its bilateral symmetry is disrupted, leading to a rotation of the heart tube and ventricle malposition.
September 26, 2025 at 7:22 PM
We uncover that the caudal splanchnic mesoderm (in green) acts as a midline anchor of the heart tube. In Vangl2 and Shroom3 mutants, its bilateral symmetry is disrupted, leading to a rotation of the heart tube and ventricle malposition.