Sigolène Meilhac
@meilhacsigolene.bsky.social
Heart Morphogenesis laboratory
Developmental biology, Congenital heart defects, Left-right asymmetry, Heterotaxy
@Institut Pasteur, Institut Imagine, Inserm, UPC - Paris
Developmental biology, Congenital heart defects, Left-right asymmetry, Heterotaxy
@Institut Pasteur, Institut Imagine, Inserm, UPC - Paris
We uncover that the caudal splanchnic mesoderm (in green) acts as a midline anchor of the heart tube. In Vangl2 and Shroom3 mutants, its bilateral symmetry is disrupted, leading to a rotation of the heart tube and ventricle malposition.
September 26, 2025 at 7:22 PM
We uncover that the caudal splanchnic mesoderm (in green) acts as a midline anchor of the heart tube. In Vangl2 and Shroom3 mutants, its bilateral symmetry is disrupted, leading to a rotation of the heart tube and ventricle malposition.
She analysed a mouse model of motile ciliopathy to show that the node can be dispensable to establish left-right asymmetry. Stay tuned !
September 25, 2025 at 6:03 AM
She analysed a mouse model of motile ciliopathy to show that the node can be dispensable to establish left-right asymmetry. Stay tuned !
Congratulations Dr Amaia Ochandorena-Saa for a beautiful PhD, defended in front of Hiroshi Hamada, @bakkerslab.bsky.social, Alice Meunier and Jeanne Amiel
September 25, 2025 at 6:03 AM
Congratulations Dr Amaia Ochandorena-Saa for a beautiful PhD, defended in front of Hiroshi Hamada, @bakkerslab.bsky.social, Alice Meunier and Jeanne Amiel
We report how ventricle can still change position after heart looping in Nodal mutants, questioning the clinical nomenclature of « D-LOOP ». D-LOOP ventricles at birth can arise from both rightward or leftward embryonic heart looping.
September 24, 2025 at 5:27 PM
We report how ventricle can still change position after heart looping in Nodal mutants, questioning the clinical nomenclature of « D-LOOP ». D-LOOP ventricles at birth can arise from both rightward or leftward embryonic heart looping.