Meghana Oak
@meghana-oak.bsky.social
PhD at IES @www.helmholtz-munich.de | BS-MS @IISER Kolkata
Epigenetics, embryonic development, cellular reprogramming. 🐸🧬
Epigenetics, embryonic development, cellular reprogramming. 🐸🧬
Pinned
Meghana Oak
@meghana-oak.bsky.social
· Jan 22
H3K4 methylation-promoted transcriptional memory ensures faithful zygotic genome activation and embryonic development
In the life of a vertebrate embryo, gene expression is initiated for the first time at zygotic genome activation (ZGA). Maternally expressed transcription factors present in the embryo are essential f...
doi.org
✨ Excited to share my latest preprint on how H3K4 methylation promotes transcriptional memory from gametes to embryos across a transcriptionally silent window — crucial for proper zygotic genome activation and development. 🐸🧬✨
📄 Check it out here: doi.org/10.1101/2025...
👇 Highlights below
📄 Check it out here: doi.org/10.1101/2025...
👇 Highlights below
Reposted by Meghana Oak
🚀 PREPRINT ALERT!
🐸 Research led by our PI @evahoermanseder.bsky.social reveals H3K4 methylation as an epigenetic memory in Xenopus embryos, vital for zygotic genome activation & development.
👏 Congratulations @meghana-oak.bsky.social & rest of authors.
📑 👀 shorturl.at/6MIRn
🔎 #OpenPeerReview
🐸 Research led by our PI @evahoermanseder.bsky.social reveals H3K4 methylation as an epigenetic memory in Xenopus embryos, vital for zygotic genome activation & development.
👏 Congratulations @meghana-oak.bsky.social & rest of authors.
📑 👀 shorturl.at/6MIRn
🔎 #OpenPeerReview
February 25, 2025 at 10:07 AM
🚀 PREPRINT ALERT!
🐸 Research led by our PI @evahoermanseder.bsky.social reveals H3K4 methylation as an epigenetic memory in Xenopus embryos, vital for zygotic genome activation & development.
👏 Congratulations @meghana-oak.bsky.social & rest of authors.
📑 👀 shorturl.at/6MIRn
🔎 #OpenPeerReview
🐸 Research led by our PI @evahoermanseder.bsky.social reveals H3K4 methylation as an epigenetic memory in Xenopus embryos, vital for zygotic genome activation & development.
👏 Congratulations @meghana-oak.bsky.social & rest of authors.
📑 👀 shorturl.at/6MIRn
🔎 #OpenPeerReview
Reposted by Meghana Oak
𝐇𝐨𝐰 𝐝𝐨 𝐜𝐞𝐥𝐥𝐬 𝐫𝐞𝐦𝐞𝐦𝐛𝐞𝐫 𝐰𝐡𝐨 𝐭𝐡𝐞𝐲 𝐚𝐫𝐞 𝐚𝐟𝐭𝐞𝐫 𝐃𝐍𝐀 𝐫𝐞𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧? Our new study “Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability” is out in 𝘚𝘤𝘪𝘦𝘯𝘤𝘦 𝘈𝘥𝘷𝘢𝘯𝘤𝘦𝘴. Led by @lleonie.bsky.social @biranalva.bsky.social 🧵 More below👇
Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability
Losing parental histones during DNA replication fork passage challenges differentiation competence and cell viability.
tinyurl.com
February 19, 2025 at 7:35 PM
𝐇𝐨𝐰 𝐝𝐨 𝐜𝐞𝐥𝐥𝐬 𝐫𝐞𝐦𝐞𝐦𝐛𝐞𝐫 𝐰𝐡𝐨 𝐭𝐡𝐞𝐲 𝐚𝐫𝐞 𝐚𝐟𝐭𝐞𝐫 𝐃𝐍𝐀 𝐫𝐞𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧? Our new study “Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability” is out in 𝘚𝘤𝘪𝘦𝘯𝘤𝘦 𝘈𝘥𝘷𝘢𝘯𝘤𝘦𝘴. Led by @lleonie.bsky.social @biranalva.bsky.social 🧵 More below👇
Looking forward to a great discussion!
My colleague Meghana @meghana-oak.bsky.social will present her work this Thursday at THE virtual Maternal Zygotic Transition symposium!
We are very excited about this opportunity! You can follow her talk by registering here:
www.giraldezlab.org/symposium/
We are very excited about this opportunity! You can follow her talk by registering here:
www.giraldezlab.org/symposium/
February 19, 2025 at 9:23 PM
Looking forward to a great discussion!
Reposted by Meghana Oak
Next Wed 12.02. at 6pm CET I will be speaking about our latest preprint: www.biorxiv.org/content/10.1... and present our findings on how we developed a machine learning model that identified new reprogramming barriers, such as H3K27ac, and our in vivo experiments to test it. See you there!
February 6, 2025 at 12:23 PM
Next Wed 12.02. at 6pm CET I will be speaking about our latest preprint: www.biorxiv.org/content/10.1... and present our findings on how we developed a machine learning model that identified new reprogramming barriers, such as H3K27ac, and our in vivo experiments to test it. See you there!
Reposted by Meghana Oak
I am thrilled to share that our latest pre-print from the @evahoermanseder.bsky.social lab 🐸🧬, is now online! Check it out here:
www.biorxiv.org/content/10.1...
Highlights and key findings from our study in the thread below 👇
www.biorxiv.org/content/10.1...
Highlights and key findings from our study in the thread below 👇
Digital Reprogramming Decodes Epigenetic Barriers of Cell Fate Changes
Fates of differentiated cells in our body can be induced to change by nuclear reprogramming. In this way, cells valuable for therapeutic purposes and disease modeling can be produced. However, the eff...
www.biorxiv.org
January 26, 2025 at 12:10 PM
I am thrilled to share that our latest pre-print from the @evahoermanseder.bsky.social lab 🐸🧬, is now online! Check it out here:
www.biorxiv.org/content/10.1...
Highlights and key findings from our study in the thread below 👇
www.biorxiv.org/content/10.1...
Highlights and key findings from our study in the thread below 👇
✨ Excited to share my latest preprint on how H3K4 methylation promotes transcriptional memory from gametes to embryos across a transcriptionally silent window — crucial for proper zygotic genome activation and development. 🐸🧬✨
📄 Check it out here: doi.org/10.1101/2025...
👇 Highlights below
📄 Check it out here: doi.org/10.1101/2025...
👇 Highlights below
H3K4 methylation-promoted transcriptional memory ensures faithful zygotic genome activation and embryonic development
In the life of a vertebrate embryo, gene expression is initiated for the first time at zygotic genome activation (ZGA). Maternally expressed transcription factors present in the embryo are essential f...
doi.org
January 22, 2025 at 1:56 PM
✨ Excited to share my latest preprint on how H3K4 methylation promotes transcriptional memory from gametes to embryos across a transcriptionally silent window — crucial for proper zygotic genome activation and development. 🐸🧬✨
📄 Check it out here: doi.org/10.1101/2025...
👇 Highlights below
📄 Check it out here: doi.org/10.1101/2025...
👇 Highlights below