jake
@mediocre-jake.bsky.social
Postdoc interested in #ubiquitin #lipid #innateimmunity #E3ligases #endoplasmicreticulum
https://findaresearcher.wehi.edu.au/chua.n
Postdoc (WEHI) https://www.wehi.edu.au/laboratory/feltham-lab/
PhD (UNSW) https://x.com/brownlabunsw?lang=en&mx=
https://findaresearcher.wehi.edu.au/chua.n
Postdoc (WEHI) https://www.wehi.edu.au/laboratory/feltham-lab/
PhD (UNSW) https://x.com/brownlabunsw?lang=en&mx=
Learning more about cryptic interaction areas of CRBN during glue binding presented by Lei Liu from Tsinghua University @tsinghuauniversity.bsky.social
Work partially in a pre-print @biorxivpreprint.bsky.social
#AusUb2025 #LorneUbqiuitin2025
@ausub.bsky.social
Work partially in a pre-print @biorxivpreprint.bsky.social
#AusUb2025 #LorneUbqiuitin2025
@ausub.bsky.social
November 22, 2025 at 1:28 AM
Learning more about cryptic interaction areas of CRBN during glue binding presented by Lei Liu from Tsinghua University @tsinghuauniversity.bsky.social
Work partially in a pre-print @biorxivpreprint.bsky.social
#AusUb2025 #LorneUbqiuitin2025
@ausub.bsky.social
Work partially in a pre-print @biorxivpreprint.bsky.social
#AusUb2025 #LorneUbqiuitin2025
@ausub.bsky.social
Very nice presentation by Phil Chamberlain from Neomorph to kick off the TPD day today at @ausub.bsky.social #AusUb2025 #LorneUbiquitin2025
From the fundamentals of glues to identifying more in the proteome to glue
From the fundamentals of glues to identifying more in the proteome to glue
November 22, 2025 at 1:22 AM
Very nice presentation by Phil Chamberlain from Neomorph to kick off the TPD day today at @ausub.bsky.social #AusUb2025 #LorneUbiquitin2025
From the fundamentals of glues to identifying more in the proteome to glue
From the fundamentals of glues to identifying more in the proteome to glue
Min Zhuang from ShanghaiTech University talking about the MARCHF5 mitochondria and peroxisome localised E3
#AusUb2025 #LorneUbiquitin2025 @ausub.bsky.social
#AusUb2025 #LorneUbiquitin2025 @ausub.bsky.social
November 22, 2025 at 1:13 AM
Min Zhuang from ShanghaiTech University talking about the MARCHF5 mitochondria and peroxisome localised E3
#AusUb2025 #LorneUbiquitin2025 @ausub.bsky.social
#AusUb2025 #LorneUbiquitin2025 @ausub.bsky.social
@impeiyee.bsky.social from the labs of Sylvie Urbe and Michael Clague presents to us a tale of CTLA4 turnover
Some cool stuff published in
@liverpooluni.bsky.social
@jcb.org
#AusUb2025 #LorneUbiquitin2025 @ausub.bsky.social
Some cool stuff published in
@liverpooluni.bsky.social
@jcb.org
#AusUb2025 #LorneUbiquitin2025 @ausub.bsky.social
November 21, 2025 at 12:47 AM
@impeiyee.bsky.social from the labs of Sylvie Urbe and Michael Clague presents to us a tale of CTLA4 turnover
Some cool stuff published in
@liverpooluni.bsky.social
@jcb.org
#AusUb2025 #LorneUbiquitin2025 @ausub.bsky.social
Some cool stuff published in
@liverpooluni.bsky.social
@jcb.org
#AusUb2025 #LorneUbiquitin2025 @ausub.bsky.social
Eric Bennett coming from
@ucsandiego.bsky.social talks about how E3s have plasticity in quality control to facilitate degradation
#AusUb2025 #LorneUbiquitin @ausub.bsky.social
@ucsandiego.bsky.social talks about how E3s have plasticity in quality control to facilitate degradation
#AusUb2025 #LorneUbiquitin @ausub.bsky.social
November 21, 2025 at 12:10 AM
Eric Bennett coming from
@ucsandiego.bsky.social talks about how E3s have plasticity in quality control to facilitate degradation
#AusUb2025 #LorneUbiquitin @ausub.bsky.social
@ucsandiego.bsky.social talks about how E3s have plasticity in quality control to facilitate degradation
#AusUb2025 #LorneUbiquitin @ausub.bsky.social
Always a pleasure to hear about the world of the HECT E3s from @sonjalorenzlab.bsky.social from Max Planck Institute for Multidisciplinary Sciences
Welcome to Australia!
Featuring work published in @cp-molcell.bsky.social @natcomms.nature.com
#LorneUbiquitin2025
#AusUb2025 @ausub.bsky.social
Welcome to Australia!
Featuring work published in @cp-molcell.bsky.social @natcomms.nature.com
#LorneUbiquitin2025
#AusUb2025 @ausub.bsky.social
November 20, 2025 at 11:22 PM
Always a pleasure to hear about the world of the HECT E3s from @sonjalorenzlab.bsky.social from Max Planck Institute for Multidisciplinary Sciences
Welcome to Australia!
Featuring work published in @cp-molcell.bsky.social @natcomms.nature.com
#LorneUbiquitin2025
#AusUb2025 @ausub.bsky.social
Welcome to Australia!
Featuring work published in @cp-molcell.bsky.social @natcomms.nature.com
#LorneUbiquitin2025
#AusUb2025 @ausub.bsky.social
The unique E2/E3 UBE2O structure presented by Kuen-Phon Wu from Academia Sinica Taiwan
#LorneUbiquitin2025 #AusUb2025 @ausub.bsky.social
#LorneUbiquitin2025 #AusUb2025 @ausub.bsky.social
November 20, 2025 at 10:44 PM
The unique E2/E3 UBE2O structure presented by Kuen-Phon Wu from Academia Sinica Taiwan
#LorneUbiquitin2025 #AusUb2025 @ausub.bsky.social
#LorneUbiquitin2025 #AusUb2025 @ausub.bsky.social
CTLH E3 ligase coming into action with Toxoplasma infection presented by Chris Tonkin
#LorneUbiquitin2025 #Ubiquitin2025 #AusUb2025
@wehi-research.bsky.social
#LorneUbiquitin2025 #Ubiquitin2025 #AusUb2025
@wehi-research.bsky.social
November 20, 2025 at 10:30 PM
CTLH E3 ligase coming into action with Toxoplasma infection presented by Chris Tonkin
#LorneUbiquitin2025 #Ubiquitin2025 #AusUb2025
@wehi-research.bsky.social
#LorneUbiquitin2025 #Ubiquitin2025 #AusUb2025
@wehi-research.bsky.social
Day 2 of the conference in Australia
Revisiting the E1-E2-E3 cascade with Chris Lima from the Memorial Sloan Kettering Cancer Center
@ausub.bsky.social
#AusUb2025 #LorneUbiquitin2025
Revisiting the E1-E2-E3 cascade with Chris Lima from the Memorial Sloan Kettering Cancer Center
@ausub.bsky.social
#AusUb2025 #LorneUbiquitin2025
November 20, 2025 at 10:04 PM
Day 2 of the conference in Australia
Revisiting the E1-E2-E3 cascade with Chris Lima from the Memorial Sloan Kettering Cancer Center
@ausub.bsky.social
#AusUb2025 #LorneUbiquitin2025
Revisiting the E1-E2-E3 cascade with Chris Lima from the Memorial Sloan Kettering Cancer Center
@ausub.bsky.social
#AusUb2025 #LorneUbiquitin2025
Sir Philip Cohen presenting on the intersection between glycogen metabolism and ubiquitination
From insulin signaling to glycogen
Really appreciate the historical tour of ubiquitin in innate immunity
@ausub.bsky.social
#ubiquitin #AusUb2025 #LorneUbiquitin2025
From insulin signaling to glycogen
Really appreciate the historical tour of ubiquitin in innate immunity
@ausub.bsky.social
#ubiquitin #AusUb2025 #LorneUbiquitin2025
November 20, 2025 at 7:01 AM
Sir Philip Cohen presenting on the intersection between glycogen metabolism and ubiquitination
From insulin signaling to glycogen
Really appreciate the historical tour of ubiquitin in innate immunity
@ausub.bsky.social
#ubiquitin #AusUb2025 #LorneUbiquitin2025
From insulin signaling to glycogen
Really appreciate the historical tour of ubiquitin in innate immunity
@ausub.bsky.social
#ubiquitin #AusUb2025 #LorneUbiquitin2025
My favorite topic
ER proteins and protein degradation
Yukio Yoshida from Tokyo Metropolitan Institute of Medical Science
Work shown published in @cp-molcell.bsky.social
#AusUb2025 #LorneUbiquitin2025
@ausub.bsky.social
ER proteins and protein degradation
Yukio Yoshida from Tokyo Metropolitan Institute of Medical Science
Work shown published in @cp-molcell.bsky.social
#AusUb2025 #LorneUbiquitin2025
@ausub.bsky.social
November 20, 2025 at 3:50 AM
My favorite topic
ER proteins and protein degradation
Yukio Yoshida from Tokyo Metropolitan Institute of Medical Science
Work shown published in @cp-molcell.bsky.social
#AusUb2025 #LorneUbiquitin2025
@ausub.bsky.social
ER proteins and protein degradation
Yukio Yoshida from Tokyo Metropolitan Institute of Medical Science
Work shown published in @cp-molcell.bsky.social
#AusUb2025 #LorneUbiquitin2025
@ausub.bsky.social
Fun facts about aryl hydrocarbon receptor presented by @andriigorelik.bsky.social at #AusUb2025 #LorneUbiquitin2025
@ox.ac.uk @ausub.bsky.social
@ox.ac.uk @ausub.bsky.social
November 20, 2025 at 3:32 AM
Fun facts about aryl hydrocarbon receptor presented by @andriigorelik.bsky.social at #AusUb2025 #LorneUbiquitin2025
@ox.ac.uk @ausub.bsky.social
@ox.ac.uk @ausub.bsky.social
More and more about E3s
Satpal from MRC Protein Phosphorylation and Ubiquitylation Unit talks about remaining E3s
#AusUb2025 #LorneUbiquitin2025
@ausub.bsky.social
Satpal from MRC Protein Phosphorylation and Ubiquitylation Unit talks about remaining E3s
#AusUb2025 #LorneUbiquitin2025
@ausub.bsky.social
November 20, 2025 at 3:13 AM
More and more about E3s
Satpal from MRC Protein Phosphorylation and Ubiquitylation Unit talks about remaining E3s
#AusUb2025 #LorneUbiquitin2025
@ausub.bsky.social
Satpal from MRC Protein Phosphorylation and Ubiquitylation Unit talks about remaining E3s
#AusUb2025 #LorneUbiquitin2025
@ausub.bsky.social
#AusUb2025
@ausub.bsky.social
Ubiquitin meets mono-ADP-ribosylation = MARUbylation
Presented by @jnpruneda.bsky.social who came all the way to Australia for the #LorneUbiquitin2025 from Oregon Health & Science University
Hopefully the US visitors have a pleasant stay
@ausub.bsky.social
Ubiquitin meets mono-ADP-ribosylation = MARUbylation
Presented by @jnpruneda.bsky.social who came all the way to Australia for the #LorneUbiquitin2025 from Oregon Health & Science University
Hopefully the US visitors have a pleasant stay
November 20, 2025 at 2:51 AM
#AusUb2025
@ausub.bsky.social
Ubiquitin meets mono-ADP-ribosylation = MARUbylation
Presented by @jnpruneda.bsky.social who came all the way to Australia for the #LorneUbiquitin2025 from Oregon Health & Science University
Hopefully the US visitors have a pleasant stay
@ausub.bsky.social
Ubiquitin meets mono-ADP-ribosylation = MARUbylation
Presented by @jnpruneda.bsky.social who came all the way to Australia for the #LorneUbiquitin2025 from Oregon Health & Science University
Hopefully the US visitors have a pleasant stay
Brenda Schulman as the first speaker of #AusUb2025
#LorneUbiquitin2025
Always amazing body of work
@mpibiochem.bsky.social
@ausub.bsky.social
#LorneUbiquitin2025
Always amazing body of work
@mpibiochem.bsky.social
@ausub.bsky.social
November 20, 2025 at 2:24 AM
Brenda Schulman as the first speaker of #AusUb2025
#LorneUbiquitin2025
Always amazing body of work
@mpibiochem.bsky.social
@ausub.bsky.social
#LorneUbiquitin2025
Always amazing body of work
@mpibiochem.bsky.social
@ausub.bsky.social
#AusUb2025 starting off with David Komander kicking off the Lorne Ubiquitin meeting in Australia
@ausub.bsky.social
#ubiquitin
@ausub.bsky.social
#ubiquitin
November 20, 2025 at 1:57 AM
#AusUb2025 starting off with David Komander kicking off the Lorne Ubiquitin meeting in Australia
@ausub.bsky.social
#ubiquitin
@ausub.bsky.social
#ubiquitin
Reposted by jake
Homeostatic control of energy metabolism by monocyte-derived macrophages
@elmiguelche.bsky.social and colleagues show that macrophages sense dysregulated iron metabolism in parenchymal cells and respond by sustaining mitochondrial function in affected cells
www.embopress.org/doi/full/10....
@elmiguelche.bsky.social and colleagues show that macrophages sense dysregulated iron metabolism in parenchymal cells and respond by sustaining mitochondrial function in affected cells
www.embopress.org/doi/full/10....
November 19, 2025 at 3:20 PM
Homeostatic control of energy metabolism by monocyte-derived macrophages
@elmiguelche.bsky.social and colleagues show that macrophages sense dysregulated iron metabolism in parenchymal cells and respond by sustaining mitochondrial function in affected cells
www.embopress.org/doi/full/10....
@elmiguelche.bsky.social and colleagues show that macrophages sense dysregulated iron metabolism in parenchymal cells and respond by sustaining mitochondrial function in affected cells
www.embopress.org/doi/full/10....
See you all at Lorne for #AusUb2025
On the bus that departed Melbourne airport with a bunch of delegates from around the world that successfully made ut
@ausub.bsky.social
On the bus that departed Melbourne airport with a bunch of delegates from around the world that successfully made ut
@ausub.bsky.social
November 19, 2025 at 11:17 PM
See you all at Lorne for #AusUb2025
On the bus that departed Melbourne airport with a bunch of delegates from around the world that successfully made ut
@ausub.bsky.social
On the bus that departed Melbourne airport with a bunch of delegates from around the world that successfully made ut
@ausub.bsky.social
Reposted by jake
We welcome Dr. Shingo Kajimura to San Antonio this week as our Center for Molecular Metabolism seminar speaker.
November 19, 2025 at 5:23 PM
We welcome Dr. Shingo Kajimura to San Antonio this week as our Center for Molecular Metabolism seminar speaker.
Reposted by jake
The review by Banani, Lee, Hyman & Rosen (NRMCB 2017) www.nature.com/articles/nrm... on biomolecular condensates has >6000 citations. It…
1. Introduced a broad definition of “biomolecular condensates,” promoting acceptance that a unifying mechanism may underlie all membrane-less compartments.
1. Introduced a broad definition of “biomolecular condensates,” promoting acceptance that a unifying mechanism may underlie all membrane-less compartments.
Biomolecular condensates: organizers of cellular biochemistry - Nature Reviews Molecular Cell Biology
In addition to membrane-bound organelles, eukaryotic cells feature various membraneless compartments, including the centrosome, the nucleolus and various granules. Many of these compartments form thro...
www.nature.com
November 17, 2025 at 7:24 AM
The review by Banani, Lee, Hyman & Rosen (NRMCB 2017) www.nature.com/articles/nrm... on biomolecular condensates has >6000 citations. It…
1. Introduced a broad definition of “biomolecular condensates,” promoting acceptance that a unifying mechanism may underlie all membrane-less compartments.
1. Introduced a broad definition of “biomolecular condensates,” promoting acceptance that a unifying mechanism may underlie all membrane-less compartments.
Reposted by jake
Feeling awed and a bit starstruck that @science.org chose to run a book review on #LabworkToLeadership!!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Leading a lab, and all it entails
A chemist offers actionable leadership advice to principal investigators
www.science.org
August 15, 2025 at 7:29 PM
Feeling awed and a bit starstruck that @science.org chose to run a book review on #LabworkToLeadership!!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by jake
Di-Gembodies (dimerized nanobodies) for improved and duplexed CryoEM of small and challenging targets!
A collaboration of @cmd.ox.ac.uk, STRUBI, @diamondlightsource.bsky.social, @rosfrankinst.bsky.social
Out now in Nature Chemical Biology @natchembio.nature.com
www.nature.com/articles/s41...
A collaboration of @cmd.ox.ac.uk, STRUBI, @diamondlightsource.bsky.social, @rosfrankinst.bsky.social
Out now in Nature Chemical Biology @natchembio.nature.com
www.nature.com/articles/s41...
Covalently constrained ‘Di-Gembodies’ enable parallel structure solutions by cryo-EM - Nature Chemical Biology
Disulfide-based dimerization of modified identical and heterologous nanobody scaffolds enables higher-order assembly for high-resolution cryo-electron microscopy structure determination that is widely...
www.nature.com
August 15, 2025 at 10:00 AM
Di-Gembodies (dimerized nanobodies) for improved and duplexed CryoEM of small and challenging targets!
A collaboration of @cmd.ox.ac.uk, STRUBI, @diamondlightsource.bsky.social, @rosfrankinst.bsky.social
Out now in Nature Chemical Biology @natchembio.nature.com
www.nature.com/articles/s41...
A collaboration of @cmd.ox.ac.uk, STRUBI, @diamondlightsource.bsky.social, @rosfrankinst.bsky.social
Out now in Nature Chemical Biology @natchembio.nature.com
www.nature.com/articles/s41...
Reposted by jake
ASBMB's symposium on #proteomics in the life sciences starts on Sunday! What topics are you most excited to learn about? Reply to let us know!
ow.ly/8aJ850WGoTr
Thank you to our sponsors, including: @biognosys.bsky.social, @abseabio.bsky.social, @evosep.bsky.social & @mobilionsystems.bsky.social!
ow.ly/8aJ850WGoTr
Thank you to our sponsors, including: @biognosys.bsky.social, @abseabio.bsky.social, @evosep.bsky.social & @mobilionsystems.bsky.social!
The 15th international symposium on proteomics in the life sciences
Aug. 17–21, 2025 | Cambridge, Mass.
ow.ly
August 15, 2025 at 4:55 AM
ASBMB's symposium on #proteomics in the life sciences starts on Sunday! What topics are you most excited to learn about? Reply to let us know!
ow.ly/8aJ850WGoTr
Thank you to our sponsors, including: @biognosys.bsky.social, @abseabio.bsky.social, @evosep.bsky.social & @mobilionsystems.bsky.social!
ow.ly/8aJ850WGoTr
Thank you to our sponsors, including: @biognosys.bsky.social, @abseabio.bsky.social, @evosep.bsky.social & @mobilionsystems.bsky.social!
www.nature.com/articles/s41...
An elegant study to use CRISPR technology to optimize the auxin-inducible degron technology
Some interesting observations using the superior degron technology
@natureportfolio.nature.com @nufeinbergmed.bsky.social
An elegant study to use CRISPR technology to optimize the auxin-inducible degron technology
Some interesting observations using the superior degron technology
@natureportfolio.nature.com @nufeinbergmed.bsky.social
Systematic comparison and base-editing-mediated directed protein evolution and functional screening yield superior auxin-inducible degron technology - Nature Communications
Traditional genetic perturbation tools such as siRNA and CRISPR knockout operate on timescales that render them unsuitable for exploring dynamic processes or studying essential genes, where chronic de...
www.nature.com
August 7, 2025 at 7:43 AM
www.nature.com/articles/s41...
An elegant study to use CRISPR technology to optimize the auxin-inducible degron technology
Some interesting observations using the superior degron technology
@natureportfolio.nature.com @nufeinbergmed.bsky.social
An elegant study to use CRISPR technology to optimize the auxin-inducible degron technology
Some interesting observations using the superior degron technology
@natureportfolio.nature.com @nufeinbergmed.bsky.social
📣 First ever international ubiquitin meeting in Australia www.lorneubiquitin.org still accepting abstracts and registrations! Hopefully we can get more people in the Asia-Pacific!
#science #conference #scicomm #Australia
#science #conference #scicomm #Australia
August 7, 2025 at 6:28 AM
📣 First ever international ubiquitin meeting in Australia www.lorneubiquitin.org still accepting abstracts and registrations! Hopefully we can get more people in the Asia-Pacific!
#science #conference #scicomm #Australia
#science #conference #scicomm #Australia