Matt Girgenti
@mattgirgenti.bsky.social
Assistant Prof YalePsych and DeptVetAffairs. Single-cell, Genomics, Neuroscience, Psychiatric Genetics. Dad of 2. MtG collector. Opinions are mine
Pinned
Matt Girgenti
@mattgirgenti.bsky.social
· Jun 18
Single-cell transcriptomic and chromatin dynamics of the human brain in PTSD - Nature
A comprehensive analysis of the cell-specific molecular regulatory mechanisms underlying post-traumatic stress disorder in the human prefrontal cortex.
www.nature.com
Very proud of our new #SingleCell work on #PTSD and #MDD out in @nature.com today.
Paper: www.nature.com/articles/s41...
News and views: www.nature.com/articles/d41...
Press: medicine.yale.edu/news-article...
Data: doi.org/10.5281/zeno...
Code: github.com/mjgirgenti/P...
Paper: www.nature.com/articles/s41...
News and views: www.nature.com/articles/d41...
Press: medicine.yale.edu/news-article...
Data: doi.org/10.5281/zeno...
Code: github.com/mjgirgenti/P...
🚨 New paper alert from our lab @yaleschoolofmed.bsky.social !
We generated DNA methylation maps from 6 postmortem brain regions (amygdala + hippocampus subregions) in PTSD, MDD, and control donors — the largest dataset of its kind! 🧠✨
📖 Read more: www.biologicalpsychiatryjournal.com/article/S000...
We generated DNA methylation maps from 6 postmortem brain regions (amygdala + hippocampus subregions) in PTSD, MDD, and control donors — the largest dataset of its kind! 🧠✨
📖 Read more: www.biologicalpsychiatryjournal.com/article/S000...
Mapping DNA methylation signatures to identify epigenetic variation across subcortical regions of the human PTSD brain
Post-traumatic stress disorder is a mental disorder that may occur in the aftermath
of severe psychological trauma. Epigenetic changes in the brain may play a critical
role in understanding the neurob...
www.biologicalpsychiatryjournal.com
November 4, 2025 at 10:51 PM
🚨 New paper alert from our lab @yaleschoolofmed.bsky.social !
We generated DNA methylation maps from 6 postmortem brain regions (amygdala + hippocampus subregions) in PTSD, MDD, and control donors — the largest dataset of its kind! 🧠✨
📖 Read more: www.biologicalpsychiatryjournal.com/article/S000...
We generated DNA methylation maps from 6 postmortem brain regions (amygdala + hippocampus subregions) in PTSD, MDD, and control donors — the largest dataset of its kind! 🧠✨
📖 Read more: www.biologicalpsychiatryjournal.com/article/S000...
Reposted by Matt Girgenti
The Snell lab is seeking a Postbaccalaureate researcher and Postdoctoral associate to join our team. More details here:
www.snelllab.org/contact-2
www.snelllab.org/contact-2
Contact | Snell Lab
www.snelllab.org
September 10, 2025 at 5:18 PM
The Snell lab is seeking a Postbaccalaureate researcher and Postdoctoral associate to join our team. More details here:
www.snelllab.org/contact-2
www.snelllab.org/contact-2
Reposted by Matt Girgenti
A summary of NIH Director Jay Bhattacharya's comments during his visit to UAB today for a town hall style presentation:
-Important for scientific work addressing our nation's health problems to be done in the same communities where those problems are concentrated
-Important for scientific work addressing our nation's health problems to be done in the same communities where those problems are concentrated
August 15, 2025 at 12:05 AM
A summary of NIH Director Jay Bhattacharya's comments during his visit to UAB today for a town hall style presentation:
-Important for scientific work addressing our nation's health problems to be done in the same communities where those problems are concentrated
-Important for scientific work addressing our nation's health problems to be done in the same communities where those problems are concentrated
Reposted by Matt Girgenti
Our recent overview of human stem cell models for studying neuropsychiatric disorders (including their limitations and future directions) is now openly available @annualreviews.bsky.social of Neuroscience
With the great @rebeccalevymdphd.bsky.social
With the great @rebeccalevymdphd.bsky.social
July 19, 2025 at 7:52 PM
Our recent overview of human stem cell models for studying neuropsychiatric disorders (including their limitations and future directions) is now openly available @annualreviews.bsky.social of Neuroscience
With the great @rebeccalevymdphd.bsky.social
With the great @rebeccalevymdphd.bsky.social
Reposted by Matt Girgenti
Meet MapMyCells! This tool saves neuroscientists precious time by comparing their data to massive, high-quality reference datasets, including our whole mouse brain multi-omics atlas and the Seattle Alzheimer’s Disease Brain Cell Atlas.
🧠📈 portal.brain-map.org/atlases-and-...
#studyBRAIN
🧠📈 portal.brain-map.org/atlases-and-...
#studyBRAIN
June 18, 2025 at 8:00 PM
Meet MapMyCells! This tool saves neuroscientists precious time by comparing their data to massive, high-quality reference datasets, including our whole mouse brain multi-omics atlas and the Seattle Alzheimer’s Disease Brain Cell Atlas.
🧠📈 portal.brain-map.org/atlases-and-...
#studyBRAIN
🧠📈 portal.brain-map.org/atlases-and-...
#studyBRAIN
Very proud of our new #SingleCell work on #PTSD and #MDD out in @nature.com today.
Paper: www.nature.com/articles/s41...
News and views: www.nature.com/articles/d41...
Press: medicine.yale.edu/news-article...
Data: doi.org/10.5281/zeno...
Code: github.com/mjgirgenti/P...
Paper: www.nature.com/articles/s41...
News and views: www.nature.com/articles/d41...
Press: medicine.yale.edu/news-article...
Data: doi.org/10.5281/zeno...
Code: github.com/mjgirgenti/P...
Single-cell transcriptomic and chromatin dynamics of the human brain in PTSD - Nature
A comprehensive analysis of the cell-specific molecular regulatory mechanisms underlying post-traumatic stress disorder in the human prefrontal cortex.
www.nature.com
June 18, 2025 at 4:53 PM
Very proud of our new #SingleCell work on #PTSD and #MDD out in @nature.com today.
Paper: www.nature.com/articles/s41...
News and views: www.nature.com/articles/d41...
Press: medicine.yale.edu/news-article...
Data: doi.org/10.5281/zeno...
Code: github.com/mjgirgenti/P...
Paper: www.nature.com/articles/s41...
News and views: www.nature.com/articles/d41...
Press: medicine.yale.edu/news-article...
Data: doi.org/10.5281/zeno...
Code: github.com/mjgirgenti/P...
Reposted by Matt Girgenti
We recently celebrated our annual Neuroscience Retreat🧠👥
Thank you so much to everyone who came and made it such a memorable retreat full of science, collaboration, and community🤝🤗📸👇
Thank you so much to everyone who came and made it such a memorable retreat full of science, collaboration, and community🤝🤗📸👇
May 30, 2025 at 2:21 PM
We recently celebrated our annual Neuroscience Retreat🧠👥
Thank you so much to everyone who came and made it such a memorable retreat full of science, collaboration, and community🤝🤗📸👇
Thank you so much to everyone who came and made it such a memorable retreat full of science, collaboration, and community🤝🤗📸👇
Reposted by Matt Girgenti
Join us today at noon 🕛 for a seminar by @michael-e-ward.bsky.social, MD, PhD, from NIH/NINDS, on neuronal lysosomes in health and disease.
Thank you to @yaleneuro.bsky.social's Shaul Yogev and @sugarrayy.bsky.social for hosting! We hope to see you there!
Thank you to @yaleneuro.bsky.social's Shaul Yogev and @sugarrayy.bsky.social for hosting! We hope to see you there!
May 12, 2025 at 12:12 PM
Join us today at noon 🕛 for a seminar by @michael-e-ward.bsky.social, MD, PhD, from NIH/NINDS, on neuronal lysosomes in health and disease.
Thank you to @yaleneuro.bsky.social's Shaul Yogev and @sugarrayy.bsky.social for hosting! We hope to see you there!
Thank you to @yaleneuro.bsky.social's Shaul Yogev and @sugarrayy.bsky.social for hosting! We hope to see you there!
Reposted by Matt Girgenti
In a new @yale.edu study, researchers led by @mattgirgenti.bsky.social from #YalePsychiatry used a comprehensive multi-omic approach to analyze postmortem brain 🧠 genomics and investigate the molecular differences 🧬 in PTSD and major depressive disorder 🔍
A Multi-Omic Approach Implicates Novel Protein Dysregulation in Post-Traumatic Stress Disorder
Yale scientists, led by senior author Matthew Girgenti, PhD, assistant professor of psychiatry, established a brain multi-omic and multi-region analysis
medicine.yale.edu
May 9, 2025 at 4:00 PM
In a new @yale.edu study, researchers led by @mattgirgenti.bsky.social from #YalePsychiatry used a comprehensive multi-omic approach to analyze postmortem brain 🧠 genomics and investigate the molecular differences 🧬 in PTSD and major depressive disorder 🔍
Excited to share our latest study of the PTSD prefrontal cortex out @GenomeMedicine. rdcu.be/ejZ3T
Our systems biology approach established a brain multi-omic, multi-region analysis comprising individuals with PTSD and MDD
Our systems biology approach established a brain multi-omic, multi-region analysis comprising individuals with PTSD and MDD
A multi-omic approach implicates novel protein dysregulation in post-traumatic stress disorder
rdcu.be
April 30, 2025 at 2:24 PM
Excited to share our latest study of the PTSD prefrontal cortex out @GenomeMedicine. rdcu.be/ejZ3T
Our systems biology approach established a brain multi-omic, multi-region analysis comprising individuals with PTSD and MDD
Our systems biology approach established a brain multi-omic, multi-region analysis comprising individuals with PTSD and MDD
Reposted by Matt Girgenti
Hot off the science presses! The largest map of the brain's wiring and activity to date is featured on the cover of @nature.com.
🧠📈 Check out 'Cortex in Context' at: www.nature.com/immersive/d4...
🧠📈 Check out 'Cortex in Context' at: www.nature.com/immersive/d4...
April 10, 2025 at 5:24 PM
Hot off the science presses! The largest map of the brain's wiring and activity to date is featured on the cover of @nature.com.
🧠📈 Check out 'Cortex in Context' at: www.nature.com/immersive/d4...
🧠📈 Check out 'Cortex in Context' at: www.nature.com/immersive/d4...
Reposted by Matt Girgenti
Obsessed with this photo I took of a California Condor at the Oregon Zoo looking out into the rain majestically 🌧️
April 10, 2025 at 6:37 PM
Obsessed with this photo I took of a California Condor at the Oregon Zoo looking out into the rain majestically 🌧️
Reposted by Matt Girgenti
Our latest study identifies a specific cell type and receptor essential for psilocybin’s long-lasting neural and behavioral effects 🍄🔬🧠🧪
Led by Ling-Xiao Shao and @ItsClaraLiao
Funded by @NIH @NIMHgov
📄 Read in @nature.com - www.nature.com/articles/s41...
1/12
Led by Ling-Xiao Shao and @ItsClaraLiao
Funded by @NIH @NIMHgov
📄 Read in @nature.com - www.nature.com/articles/s41...
1/12
Psilocybin’s lasting action requires pyramidal cell types and 5-HT2A receptors - Nature
A pyramidal cell type and the 5-HT2A receptor in the medial frontal cortex have essential roles in psilocybin’s long-term drug action.
www.nature.com
April 2, 2025 at 4:09 PM
Our latest study identifies a specific cell type and receptor essential for psilocybin’s long-lasting neural and behavioral effects 🍄🔬🧠🧪
Led by Ling-Xiao Shao and @ItsClaraLiao
Funded by @NIH @NIMHgov
📄 Read in @nature.com - www.nature.com/articles/s41...
1/12
Led by Ling-Xiao Shao and @ItsClaraLiao
Funded by @NIH @NIMHgov
📄 Read in @nature.com - www.nature.com/articles/s41...
1/12