María Vélez-Brochero
@matiavelezb0310.bsky.social
Ph.D Candidate in Immunology at @Rutgershealth l BSc in Molecular Microbiology | 🍄🦠🧬
Reposted by María Vélez-Brochero
Reposted by María Vélez-Brochero
Toxic amyloid-β induces oxidation & fragmentation of mitoDNA in microglia, facilitating B-to-Z conformational transition that activates ZBP1-RIPK1 driven neuroinflammation in #Alzheimer's @cp-immunity.bsky.social
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
September 2, 2025 at 4:34 PM
Toxic amyloid-β induces oxidation & fragmentation of mitoDNA in microglia, facilitating B-to-Z conformational transition that activates ZBP1-RIPK1 driven neuroinflammation in #Alzheimer's @cp-immunity.bsky.social
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
Reposted by María Vélez-Brochero
Are the mRNA vaccines incredible? YES!
Are the mRNA vaccines perfect? No.
Have the mRNA vaccines saved millions of lives? YES!
Can we make the mRNA vaccines even better? YES!
Can we use mRNA vaccine technology to prevent and treat many other diseases? YES!
Fund mRNA research!
Are the mRNA vaccines perfect? No.
Have the mRNA vaccines saved millions of lives? YES!
Can we make the mRNA vaccines even better? YES!
Can we use mRNA vaccine technology to prevent and treat many other diseases? YES!
Fund mRNA research!
August 19, 2025 at 2:54 AM
Are the mRNA vaccines incredible? YES!
Are the mRNA vaccines perfect? No.
Have the mRNA vaccines saved millions of lives? YES!
Can we make the mRNA vaccines even better? YES!
Can we use mRNA vaccine technology to prevent and treat many other diseases? YES!
Fund mRNA research!
Are the mRNA vaccines perfect? No.
Have the mRNA vaccines saved millions of lives? YES!
Can we make the mRNA vaccines even better? YES!
Can we use mRNA vaccine technology to prevent and treat many other diseases? YES!
Fund mRNA research!
Reposted by María Vélez-Brochero
TNF and type I interferon crosstalk controls the fate and function of plasmacytoid dendritic cells @natimmunol.nature.com @idoyagalab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 12, 2025 at 6:39 PM
TNF and type I interferon crosstalk controls the fate and function of plasmacytoid dendritic cells @natimmunol.nature.com @idoyagalab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by María Vélez-Brochero
"(...) it is unclear whether NET-mediated vascular occlusion actively drives necrosis & how this in turn would affect metastasis. Here we examined how tumours become necrotic, not by passively outgrowing the nutrient supply but by actively altering haematopoiesis to favour intravasc. NET formation"
Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature
Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.
www.nature.com
July 26, 2025 at 2:36 PM
"(...) it is unclear whether NET-mediated vascular occlusion actively drives necrosis & how this in turn would affect metastasis. Here we examined how tumours become necrotic, not by passively outgrowing the nutrient supply but by actively altering haematopoiesis to favour intravasc. NET formation"
Reposted by María Vélez-Brochero
📝Call for papers📝
I'm co-editing a @microbiologysociety.org #JMedMicro collection on Fungal Pathogenesis.
Contribute a review, research or short communication article by Nov 2025 (flexible)
If interested, get in touch!
#FungalPathogens #MedicalMycology #InfectiousDiseases
I'm co-editing a @microbiologysociety.org #JMedMicro collection on Fungal Pathogenesis.
Contribute a review, research or short communication article by Nov 2025 (flexible)
If interested, get in touch!
#FungalPathogens #MedicalMycology #InfectiousDiseases
Fungal Pathogenesis: Mechanisms, Resistance, and Threats | Microbiology Society
Fungi are a major global health concern, responsible for over a billion infections annually and an estimated 1.5 million deaths each year. Despite their substantial impact on human health and healthca...
www.microbiologyresearch.org
July 21, 2025 at 1:54 PM
📝Call for papers📝
I'm co-editing a @microbiologysociety.org #JMedMicro collection on Fungal Pathogenesis.
Contribute a review, research or short communication article by Nov 2025 (flexible)
If interested, get in touch!
#FungalPathogens #MedicalMycology #InfectiousDiseases
I'm co-editing a @microbiologysociety.org #JMedMicro collection on Fungal Pathogenesis.
Contribute a review, research or short communication article by Nov 2025 (flexible)
If interested, get in touch!
#FungalPathogens #MedicalMycology #InfectiousDiseases
Reposted by María Vélez-Brochero
#Medsky🧪 #IDsky #Immunosky #publichealth #Vaccines generate long-lived plasma cells & #memoryBcells (Bmems) that may re-enter secondary germinal centers (GCs) to further mutate their B cell receptor upon 💉& re-exposure to antigen.
Recap
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Recap
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Memory B cells - Nature Reviews Immunology
Memory B cells are critical for protection against repeated infections, particularly with viral variants, and understanding their function and development is key for successful vaccine development. Th...
www.nature.com
July 2, 2025 at 1:48 AM
Reposted by María Vélez-Brochero
#Medsky🧪 #IDsky #immunosky #publichealth During #mold infections, crosstalk between 🫁 epithelial cells & fungicidal #neutrophils via GM-CSF improves survival, according to a new study in 🐁 @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
GM-CSF–mediated epithelial-immune cell cross-talk orchestrates pulmonary immunity to Aspergillus fumigatus
During mold infection, epithelial-derived GM-CSF licenses neutrophil killing of fungal cells, leading to improved survival.
www.science.org
March 21, 2025 at 6:35 PM
#Medsky🧪 #IDsky #immunosky #publichealth During #mold infections, crosstalk between 🫁 epithelial cells & fungicidal #neutrophils via GM-CSF improves survival, according to a new study in 🐁 @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by María Vélez-Brochero
Excited to post for the first time to present our exciting new paper @Nature. The fruit of massive work by Tommaso Vicanolo, @alazozcan.bsky.social and Jackson Li, and our superb collaborators Laiguan and Stefan Uderhardt. True teamwork!
Free link: rdcu.be/eeeA2
www.nature.com/articles/s41...
Free link: rdcu.be/eeeA2
www.nature.com/articles/s41...
Matrix-producing neutrophils populate and shield the skin
Nature - A population of neutrophils in the skin produces extracellular matrix, providing a defence strategy by reinforcing the barrier properties of the skin and helping to block the entry of...
rdcu.be
March 19, 2025 at 9:28 PM
Excited to post for the first time to present our exciting new paper @Nature. The fruit of massive work by Tommaso Vicanolo, @alazozcan.bsky.social and Jackson Li, and our superb collaborators Laiguan and Stefan Uderhardt. True teamwork!
Free link: rdcu.be/eeeA2
www.nature.com/articles/s41...
Free link: rdcu.be/eeeA2
www.nature.com/articles/s41...
Reposted by María Vélez-Brochero
Exciting opportunity awaits! Deadline has been extended to the 30th of March
Apply here:
www.immunopaedia.org.za/course-appli...
www.immunopaedia.org.za/course-appli...
#scholarship #education #science #immunology #course #conference #network
Apply here:
www.immunopaedia.org.za/course-appli...
www.immunopaedia.org.za/course-appli...
#scholarship #education #science #immunology #course #conference #network
March 20, 2025 at 9:46 AM
Exciting opportunity awaits! Deadline has been extended to the 30th of March
Apply here:
www.immunopaedia.org.za/course-appli...
www.immunopaedia.org.za/course-appli...
#scholarship #education #science #immunology #course #conference #network
Apply here:
www.immunopaedia.org.za/course-appli...
www.immunopaedia.org.za/course-appli...
#scholarship #education #science #immunology #course #conference #network