The likely mechanism?

We show that whereas wildtype DNMT3A stimulates TDG-mediated methylation damage repair, mutated DNMT3A impairs this process.

Thank you Madelon! 😄

Thanks Dorien! ☺️

In this work we show that double mutant DNMT3A AML, a subgroup comprising approximately 4% of the complete AML population, is linked to increased methylation-linked DNA damage, diverging driver mutation landscape and unfavorable overall survival. (2/2)

Great, looks cool!

Hahah, thanks for trying, I did not notice! I'll try to stop by tonight, do you know the number of the poster?

Hahaha we can definitely work with that!

METHods section was *right there*

Definitely! I would love to be added @alessandrodonada.bsky.social 🧪🩸