Manuel A. S-G
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mas-g.bsky.social
Manuel A. S-G
@mas-g.bsky.social
76 followers 150 following 1 posts
Post-doc at the University of Edinburgh. Neuts and hypoxia it is!
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mas-g.bsky.social
Manuel A. S-G @mas-g.bsky.social · Oct 28
Thrilled to see online our latest paper on hypoxia and neutrophil memory #Huge_team_effort @walmsley-lab.bsky.social in @edinuni-irr.bsky.social. Huge thanks to all our collaborators and blood donors.

rdcu.be/eM5MT
Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity
Nature Immunology - Walmsley and colleagues report that systemic hypoxia induces persistent loss of histone H3K4me3 marks and epigenetic reprogramming in neutrophil progenitors, resulting in...
rdcu.be
Reposted by Manuel A. S-G
natrevimmunol.nature.com
Highlight of @natimmunol.nature.com paper by @mas-g.bsky.social @walmsley-lab.bsky.social showing epigenetic reprogramming of neutrophils in response to hypoxia to reduce lung tissue damage
#immunosky
Hypoxia-induced epigenetic reprogramming of neutrophil progenitors - Nature Reviews Immunology
Sanchez-Garcia et al. report that systemic hypoxia-induced epigenetic reprogramming of neutrophil progenitors in the bone marrow reduces their effector function to limit lung tissue damage.
www.nature.com
November 5, 2025 at 11:43 AM
mas-g.bsky.social
Thrilled to see online our latest paper on hypoxia and neutrophil memory #Huge_team_effort @walmsley-lab.bsky.social in @edinuni-irr.bsky.social. Huge thanks to all our collaborators and blood donors.

rdcu.be/eM5MT
Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity
Nature Immunology - Walmsley and colleagues report that systemic hypoxia induces persistent loss of histone H3K4me3 marks and epigenetic reprogramming in neutrophil progenitors, resulting in...
rdcu.be
October 28, 2025 at 6:38 PM
Reposted by Manuel A. S-G
edinuni-irr.bsky.social
How low blood oxygen can affect your body's immune defences 🛡️

A new study reveals that neutrophils have their genetic material modified by hypoxia and how the BCG vaccine may reverse this immune response.

Our article: edin.ac/49nENu4
Nature Immunology paper: www.nature.com/articles/s41...
Device that measures blood oxygen levels on the finger of an elderly individual
October 28, 2025 at 10:30 AM
Reposted by Manuel A. S-G
pranvera.bsky.social
Our most recent work entitled “Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity” is now published. Well done @mas-g.bsky.social. rdcu.be/eM5MT
Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity
Nature Immunology - Walmsley and colleagues report that systemic hypoxia induces persistent loss of histone H3K4me3 marks and epigenetic reprogramming in neutrophil progenitors, resulting in...
rdcu.be
October 28, 2025 at 11:24 AM
Reposted by Manuel A. S-G
ajbrenes.com
#Neutrophils are short lived cells, yet in ARDS display long term changes, with impaired neutrophil functions even after 6 months. How can they undergo long term reprogramming?

this is what @mas-g.bsky.social answered, mapping changes to neut. progenitors. @walmsley-lab.bsky.social #immunosky
Hypoxia induces histone clipping and H3K4me3 loss in neutrophil progenitors resulting in long-term impairment of neutrophil immunity - Nature Immunology
Walmsley and colleagues report that systemic hypoxia induces persistent loss of histone H3K4me3 marks and epigenetic reprogramming in neutrophil progenitors, resulting in long-term impairment of subse...
www.nature.com
October 28, 2025 at 11:55 AM
Reposted by Manuel A. S-G
aidarodrigo.bsky.social
🚨 Heads-up: a little over a week to apply for this exciting postdoc opportunity in Edinburgh @edinuni-irr.bsky.social! 🚨

I will be in Liverpool for #biologists100. Happy to chat about the position, our research, setting up a lab, spiny mice, axolotls, and whatnot!
aidarodrigo.bsky.social Aida Rodrigo @aidarodrigo.bsky.social · Mar 5
📢 We are hiring! 📢

We are looking for a postdoc to help us work out why mice cannot regenerate the spinal cord but spiny mice *can*.

More info and how to apply: tinyurl.com/4m6yzbef

Get in touch if interested!
Postdoctoral Research Associate
We are looking for a Postdoctoral Research Associate to join our group at the Centre for Regenerative Medicine (CRM) and the Institute for Regeneration and Repair (IRR), The University of Edinburgh.
tinyurl.com
March 23, 2025 at 2:56 PM