Marco Radi
@marcoradi.bsky.social
MR Research Lab - Drug Discovery and Sustainable MedChem
#ChemSky 🧪⚡💊
https://sites.google.com/site/marcoradi/home
#ChemSky 🧪⚡💊
https://sites.google.com/site/marcoradi/home
🧪 The registration deadline for the First #PANVIRIDE Antiviral Drug Discovery Conference in Gizzeria Lido, Italy, has been extended! Here: lnkd.in/d6dnB8cc
Don’t miss the opportunity to share your work, connect with peers, and showcase your research in a high-impact venue.
Don’t miss the opportunity to share your work, connect with peers, and showcase your research in a high-impact venue.
September 11, 2025 at 6:44 AM
🧪 The registration deadline for the First #PANVIRIDE Antiviral Drug Discovery Conference in Gizzeria Lido, Italy, has been extended! Here: lnkd.in/d6dnB8cc
Don’t miss the opportunity to share your work, connect with peers, and showcase your research in a high-impact venue.
Don’t miss the opportunity to share your work, connect with peers, and showcase your research in a high-impact venue.
🧪 We are delighted to present this #Wiley #Special #Collection inspired by two #international #conferences which debuted this year:
📍The First International Conference on Anti-Infectives 2025 in Saarbrücken, Germany
📍The First #PANVIRIDE Antiviral Drug Discovery Conference in Gizzeria Lido, Italy
📍The First International Conference on Anti-Infectives 2025 in Saarbrücken, Germany
📍The First #PANVIRIDE Antiviral Drug Discovery Conference in Gizzeria Lido, Italy
September 2, 2025 at 6:58 AM
🧪 We are delighted to present this #Wiley #Special #Collection inspired by two #international #conferences which debuted this year:
📍The First International Conference on Anti-Infectives 2025 in Saarbrücken, Germany
📍The First #PANVIRIDE Antiviral Drug Discovery Conference in Gizzeria Lido, Italy
📍The First International Conference on Anti-Infectives 2025 in Saarbrücken, Germany
📍The First #PANVIRIDE Antiviral Drug Discovery Conference in Gizzeria Lido, Italy
🧪Complex diseases don’t work like broken clock that can be fixed by replacing a single part
As an alternative to the reductionist approach, we present a #multitarget #polypharmacological strategy to reduce drug #burden & prevent pulmonary #exacerbations in #CF
www.sciencedirect.com/science/arti...
As an alternative to the reductionist approach, we present a #multitarget #polypharmacological strategy to reduce drug #burden & prevent pulmonary #exacerbations in #CF
www.sciencedirect.com/science/arti...
August 29, 2025 at 2:00 PM
🧪Complex diseases don’t work like broken clock that can be fixed by replacing a single part
As an alternative to the reductionist approach, we present a #multitarget #polypharmacological strategy to reduce drug #burden & prevent pulmonary #exacerbations in #CF
www.sciencedirect.com/science/arti...
As an alternative to the reductionist approach, we present a #multitarget #polypharmacological strategy to reduce drug #burden & prevent pulmonary #exacerbations in #CF
www.sciencedirect.com/science/arti...
🧪 In this work, we challenged ourselves to look beyond conventional #Antiviral #Drug #Discovery approaches, exploring an #evolution-#inspired strategy rooted in #prebiotic #chemistry. It’s been an exciting journey of creativity, curiosity, and collaboration.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 17, 2025 at 8:11 AM
🧪 In this work, we challenged ourselves to look beyond conventional #Antiviral #Drug #Discovery approaches, exploring an #evolution-#inspired strategy rooted in #prebiotic #chemistry. It’s been an exciting journey of creativity, curiosity, and collaboration.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
🧪This event, held in Catanzaro (Italy) on September 30 2025, will be focused on innovative #antiviral #DrugDiscovery #strategies.
To view the full program, register and submit an abstract, visit:
👉 lnkd.in/d6dnB8cc
📅 Registration deadline: July 25, 2025
📧 For further information: panviride@gmail.com
To view the full program, register and submit an abstract, visit:
👉 lnkd.in/d6dnB8cc
📅 Registration deadline: July 25, 2025
📧 For further information: panviride@gmail.com
June 25, 2025 at 9:24 AM
🧪This event, held in Catanzaro (Italy) on September 30 2025, will be focused on innovative #antiviral #DrugDiscovery #strategies.
To view the full program, register and submit an abstract, visit:
👉 lnkd.in/d6dnB8cc
📅 Registration deadline: July 25, 2025
📧 For further information: panviride@gmail.com
To view the full program, register and submit an abstract, visit:
👉 lnkd.in/d6dnB8cc
📅 Registration deadline: July 25, 2025
📧 For further information: panviride@gmail.com
The #PANVIRIDE team from the Università degli Studi di Parma. 🧪
A #multidisciplinary effort towards new Broad-Spectrum Antivirals ( #BSAs).💊
Learn more about our mission, research, and Partners on our official website:
🔗 panviride.eu
www.linkedin.com/feed/update/...
A #multidisciplinary effort towards new Broad-Spectrum Antivirals ( #BSAs).💊
Learn more about our mission, research, and Partners on our official website:
🔗 panviride.eu
www.linkedin.com/feed/update/...
The #PANVIRIDE team from the Università degli studi di Parma. | Marco Radi
The #PANVIRIDE team from the Università degli studi di Parma.
A #multidisciplinary effort towards new Broad-Spectrum Antivirals (#BSAs).
Learn more about our mission, research, and Partners on our o...
www.linkedin.com
June 19, 2025 at 6:39 AM
The #PANVIRIDE team from the Università degli Studi di Parma. 🧪
A #multidisciplinary effort towards new Broad-Spectrum Antivirals ( #BSAs).💊
Learn more about our mission, research, and Partners on our official website:
🔗 panviride.eu
www.linkedin.com/feed/update/...
A #multidisciplinary effort towards new Broad-Spectrum Antivirals ( #BSAs).💊
Learn more about our mission, research, and Partners on our official website:
🔗 panviride.eu
www.linkedin.com/feed/update/...
Reposted by Marco Radi
The interactions of droplets or water can spark flashes of electricity - microlightning - which would have provided enough energy to create the key organic molecules needed for life to emerge www.newscientist.com/article/2472...
The surprising new idea behind what sparked life on Earth
We may be starting to get a grasp on what kick-started life on Earth – and it could help us search for it on other planets
www.newscientist.com
March 15, 2025 at 5:46 AM
The interactions of droplets or water can spark flashes of electricity - microlightning - which would have provided enough energy to create the key organic molecules needed for life to emerge www.newscientist.com/article/2472...
Reposted by Marco Radi
Take a look at 'Late-stage functionalization of the 4-amino-2-pyridone chemotype using electrochemical and MCR approaches'
From @marcoradi.bsky.social and first author Lisa Giannessi.
From @marcoradi.bsky.social and first author Lisa Giannessi.
Late-stage functionalization of the 4-amino-2-pyridone chemotype using electrochemical and MCR approaches
We report the development and application of different strategies for the late-stage functionalization (LSF) of the biologically relevant 4-amino-2-pyridone chemotype. Using the recently discovered…
buff.ly
March 6, 2025 at 12:00 PM
Take a look at 'Late-stage functionalization of the 4-amino-2-pyridone chemotype using electrochemical and MCR approaches'
From @marcoradi.bsky.social and first author Lisa Giannessi.
From @marcoradi.bsky.social and first author Lisa Giannessi.
Reposted by Marco Radi
The Role of ATP Hydrolysis and Product Release in the Translocation Mechanism of SARS-CoV-2 NSP13 https://www.biorxiv.org/content/10.1101/2023.09.28.560057v1
The Role of ATP Hydrolysis and Product Release in the Translocation Mechanism of SARS-CoV-2 NSP13 https://www.biorxiv.org/content/10.1101/2023.09.28.560057v1
In response to the emergence of COVID-19, caused by SARS-CoV-2, there has been a growing interest in
www.biorxiv.org
September 30, 2023 at 12:50 AM
The Role of ATP Hydrolysis and Product Release in the Translocation Mechanism of SARS-CoV-2 NSP13 https://www.biorxiv.org/content/10.1101/2023.09.28.560057v1
Reposted by Marco Radi
The new issue of #ChemMedChem (@chemistryeurope.bsky.social) is out!
chemistry-europe.onlinelibrary.wiley.com/toc/18607187...
chemistry-europe.onlinelibrary.wiley.com/toc/18607187...
February 21, 2025 at 7:58 AM
The new issue of #ChemMedChem (@chemistryeurope.bsky.social) is out!
chemistry-europe.onlinelibrary.wiley.com/toc/18607187...
chemistry-europe.onlinelibrary.wiley.com/toc/18607187...
Reposted by Marco Radi
The new perspective from the @euromedchem.bsky.social Best Practice Initiative is now online: chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1... Best practice recommendations for the optimization from a Hit to a Lead. Kudos to Bob Young & Jean Quancard for driving this initiative!
February 21, 2025 at 7:55 AM
The new perspective from the @euromedchem.bsky.social Best Practice Initiative is now online: chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1... Best practice recommendations for the optimization from a Hit to a Lead. Kudos to Bob Young & Jean Quancard for driving this initiative!
🤦
Giving infectious disease research a break, as promised by the MAHA agenda.
Let's break down what exactly this Executive Order is *really* saying.
Fortunately, I speak fluent anti-vax grifterese & can translate.
www.whitehouse.gov/presidential...
Let's break down what exactly this Executive Order is *really* saying.
Fortunately, I speak fluent anti-vax grifterese & can translate.
www.whitehouse.gov/presidential...
Establishing the President's Make America Healthy Again Commission
By the authority vested in me as President by the Constitution and the laws of the United States of America, it is hereby ordered: Section 1.
www.whitehouse.gov
February 14, 2025 at 1:55 PM
🤦
An excellent perspective on different classes of #helicase #inhibitors 🧪
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Structural Chemistry of Helicase Inhibition
Helicases are essential motor enzymes that couple nucleoside-triphosphate hydrolysis with DNA or RNA strand unwinding. Helicases are integral to replication, transcription, splicing, and translation o...
pubs.acs.org
February 14, 2025 at 10:43 AM
An excellent perspective on different classes of #helicase #inhibitors 🧪
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Reposted by Marco Radi
Nature is asking for information about how your research is being affected by recent actions. Link is in article below. 🧪
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Are the Trump team’s actions affecting your research? How to contact Nature
Use this form to share information with Nature’s news team, or to make suggestions for future coverage.
www.nature.com
February 14, 2025 at 6:56 AM
Nature is asking for information about how your research is being affected by recent actions. Link is in article below. 🧪
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Reposted by Marco Radi
A big loss and very bad sign for NIH, folks
Lawrence Tabak, longtime principal deputy director of the National Institutes of Health, has abruptly resigned—surprising even his own lab staff and the broader community. scim.ag/4hR40OE
Top NIH official suddenly steps down
Lawrence Tabak had served in various roles in director’s office for many years
scim.ag
February 12, 2025 at 4:40 PM
A big loss and very bad sign for NIH, folks
The sound of silence 🧪
Biopharma companies and CEOs are keeping their heads down at their own peril. They should speak up about what’s happening to the NIH and other science agencies before it’s too late.
Silence gives consent. And no one should consent to this.
Silence gives consent. And no one should consent to this.
Stand Up And Be Counted
www.science.org
February 12, 2025 at 5:41 PM
The sound of silence 🧪
Best thing I did so far....
February 8, 2025 at 4:28 PM
Best thing I did so far....
Reposted by Marco Radi
February 7, 2025 at 9:54 AM
🧪Have you ever wondered whether targeting #PI4KB and #Src / #Abl host kinases could be the next big thing in broad-spectrum #antiviral strategies? 🧐 Well, so did we! But instead of just wondering, we dug deep into the literature and wrote a whole review about it
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
February 6, 2025 at 10:06 PM
🧪Have you ever wondered whether targeting #PI4KB and #Src / #Abl host kinases could be the next big thing in broad-spectrum #antiviral strategies? 🧐 Well, so did we! But instead of just wondering, we dug deep into the literature and wrote a whole review about it
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Marco Radi
A detailed look at fresh samples taken from asteroid Bennu confirms that organic chemistry (and the molecules of life) are everywhere:
Fresh Asteroid, Getcher Fresh Asteroid Here
www.science.org
January 31, 2025 at 7:17 PM
A detailed look at fresh samples taken from asteroid Bennu confirms that organic chemistry (and the molecules of life) are everywhere:
Reposted by Marco Radi
Great overview of formulations fundamentals for medicinal chemists from Drug Hunter. drughunter.com/resource/the...
The Modern Medicinal Chemist’s Guide to Formulations
With increasingly tight timelines between bench and clinic, considering formulation strategies early on can give your program a competitive edge. This succinct formulations guide provides specific cli...
drughunter.com
January 29, 2025 at 6:26 PM
Great overview of formulations fundamentals for medicinal chemists from Drug Hunter. drughunter.com/resource/the...
Reposted by Marco Radi
Via @dereklowe.bsky.social: I fear that we are about to enter a Lysenko-like era for American science. Can only hope that our privately funded organizations can keep doing good science, ride out this dark age and be able to pick up when the dust settles. www.science.org/content/blog...
Attacking Estrogen-Receptor-Positive Breast Cancer
www.science.org
January 25, 2025 at 4:17 AM
Via @dereklowe.bsky.social: I fear that we are about to enter a Lysenko-like era for American science. Can only hope that our privately funded organizations can keep doing good science, ride out this dark age and be able to pick up when the dust settles. www.science.org/content/blog...
“It sounds like someone trying to sell a new car model by pointing out that its windows roll up and down much more quickly”
Will AI revolutionise drug design and discovery? Not the parts that count, says @dereklowe.bsky.social. Biology doesn’t care whether a drug was designed by a human or an algorithm, and there is no AI yet that can competently predict clinical trial outcomes.
www.chemistryworld.com/opinion/robo...
www.chemistryworld.com/opinion/robo...
Robots queuing up to fail
Claims of an AI revolution in drug discovery are missing the biggest problem
www.chemistryworld.com
January 25, 2025 at 8:56 AM
“It sounds like someone trying to sell a new car model by pointing out that its windows roll up and down much more quickly”