Marcell Harhai
@marcellharhai.bsky.social
MD on a PhD journey 🌱 | moon-tracker, ballroom dancer, roller skate-enthusiast 🌝💃🛼
🇭🇺🇸🇪🏳️🌈he/him
📍🇨🇭 @jourdainlab.bsky.social, @dib-unil.bsky.social, @unil.bsky.social
https://www.linkedin.com/in/marcellharhai
🇭🇺🇸🇪🏳️🌈he/him
📍🇨🇭 @jourdainlab.bsky.social, @dib-unil.bsky.social, @unil.bsky.social
https://www.linkedin.com/in/marcellharhai
Pinned
Marcell Harhai
@marcellharhai.bsky.social
· Jul 28
An updated inventory of genes essential for oxidative phosphorylation identifies a mitochondrial origin in familial Ménière’s disease
Harhai and collaborators expand the catalog of genes essential for oxidative phosphorylation
and implicate FAM136A in mitochondrial proteostasis. Their findings suggest a mitochondrial
contribution to...
www.cell.com
Here it is❗️Our updated inventory of genes required for #OXPHOS & findings on #mito defects in #Menieres is now out at Cell Reports by Cell Press! 🎉
Thank you to all of our collaborators and funding sources, this was a great and exciting project from start to finish. 💫
www.cell.com/cell-reports...
Thank you to all of our collaborators and funding sources, this was a great and exciting project from start to finish. 💫
www.cell.com/cell-reports...
Reposted by Marcell Harhai
Very excited to share the published version of our #uridine #CRISPR screen in naturemetabolism.bsky.social! 🎉
Led by Abigail Strefeler with @pagliarini-lab.bsky.social @zakbaker.bsky.social and team!
#NUDT5 #DMQ @dib-unil.bsky.social @fbm-unil.bsky.social
🔗 www.nature.com/articles/s42...
🧵1/17
Led by Abigail Strefeler with @pagliarini-lab.bsky.social @zakbaker.bsky.social and team!
#NUDT5 #DMQ @dib-unil.bsky.social @fbm-unil.bsky.social
🔗 www.nature.com/articles/s42...
🧵1/17
Uridine-sensitized screening identifies demethoxy-coenzyme Q and NUDT5 as regulators of nucleotide synthesis - Nature Metabolism
A uridine-sensitized CRISPR-Cas9 screening identifies demethoxy-CoQ as an alternative electron acceptor in the absence of CoQ, and NUDT5 as a regulator of de novo pyrimidine synthesis via its interact...
www.nature.com
November 13, 2025 at 10:19 AM
Very excited to share the published version of our #uridine #CRISPR screen in naturemetabolism.bsky.social! 🎉
Led by Abigail Strefeler with @pagliarini-lab.bsky.social @zakbaker.bsky.social and team!
#NUDT5 #DMQ @dib-unil.bsky.social @fbm-unil.bsky.social
🔗 www.nature.com/articles/s42...
🧵1/17
Led by Abigail Strefeler with @pagliarini-lab.bsky.social @zakbaker.bsky.social and team!
#NUDT5 #DMQ @dib-unil.bsky.social @fbm-unil.bsky.social
🔗 www.nature.com/articles/s42...
🧵1/17
Here it is❗️Our updated inventory of genes required for #OXPHOS & findings on #mito defects in #Menieres is now out at Cell Reports by Cell Press! 🎉
Thank you to all of our collaborators and funding sources, this was a great and exciting project from start to finish. 💫
www.cell.com/cell-reports...
Thank you to all of our collaborators and funding sources, this was a great and exciting project from start to finish. 💫
www.cell.com/cell-reports...
An updated inventory of genes essential for oxidative phosphorylation identifies a mitochondrial origin in familial Ménière’s disease
Harhai and collaborators expand the catalog of genes essential for oxidative phosphorylation
and implicate FAM136A in mitochondrial proteostasis. Their findings suggest a mitochondrial
contribution to...
www.cell.com
July 28, 2025 at 7:17 AM
Here it is❗️Our updated inventory of genes required for #OXPHOS & findings on #mito defects in #Menieres is now out at Cell Reports by Cell Press! 🎉
Thank you to all of our collaborators and funding sources, this was a great and exciting project from start to finish. 💫
www.cell.com/cell-reports...
Thank you to all of our collaborators and funding sources, this was a great and exciting project from start to finish. 💫
www.cell.com/cell-reports...
Happy to have been part of this exciting mito project with my favourite experiment - the Seahorse. See the freshly published article below! 🧫
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
POLR1A inhibits ferroptosis by regulating TFAM-mediated mitophagy and iron homeostasis
Evasion of programmed cell death (PCD) is a hallmark of cancer, yet the mechanisms underlying resistance to ferroptosis – an iron-dependent form of PC…
www.sciencedirect.com
July 15, 2025 at 7:50 AM
Happy to have been part of this exciting mito project with my favourite experiment - the Seahorse. See the freshly published article below! 🧫
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Marcell Harhai
🚨 New preprint available! Third and final in the #CRISPR screen series!🚨
👉🏻 Uridine-sensitized screening identifies genes and metabolic regulators of #nucleotide synthesis
www.biorxiv.org/content/10.1...
By A. Strefeler in collaboration with Dave Pagliarini and team.
@DIB_UNIL @FBM_UNIL
🧵 1/9
👉🏻 Uridine-sensitized screening identifies genes and metabolic regulators of #nucleotide synthesis
www.biorxiv.org/content/10.1...
By A. Strefeler in collaboration with Dave Pagliarini and team.
@DIB_UNIL @FBM_UNIL
🧵 1/9
www.biorxiv.org
March 14, 2025 at 8:14 AM
🚨 New preprint available! Third and final in the #CRISPR screen series!🚨
👉🏻 Uridine-sensitized screening identifies genes and metabolic regulators of #nucleotide synthesis
www.biorxiv.org/content/10.1...
By A. Strefeler in collaboration with Dave Pagliarini and team.
@DIB_UNIL @FBM_UNIL
🧵 1/9
👉🏻 Uridine-sensitized screening identifies genes and metabolic regulators of #nucleotide synthesis
www.biorxiv.org/content/10.1...
By A. Strefeler in collaboration with Dave Pagliarini and team.
@DIB_UNIL @FBM_UNIL
🧵 1/9
Reposted by Marcell Harhai
New preprint from the lab! 🚨
🧫 New galactose #CRISPR screening strategy
🎯 481 genes required for #OXPHOS
⚙️ #FAM136A in IMS proteostasis
👂Mito defects in #Menieres disease
by @marcellharhai.bsky.social @fbm-unil.bsky.social
A short thread 1/5
www.biorxiv.org/content/10.1...
🧫 New galactose #CRISPR screening strategy
🎯 481 genes required for #OXPHOS
⚙️ #FAM136A in IMS proteostasis
👂Mito defects in #Menieres disease
by @marcellharhai.bsky.social @fbm-unil.bsky.social
A short thread 1/5
www.biorxiv.org/content/10.1...
January 30, 2025 at 7:58 AM
New preprint from the lab! 🚨
🧫 New galactose #CRISPR screening strategy
🎯 481 genes required for #OXPHOS
⚙️ #FAM136A in IMS proteostasis
👂Mito defects in #Menieres disease
by @marcellharhai.bsky.social @fbm-unil.bsky.social
A short thread 1/5
www.biorxiv.org/content/10.1...
🧫 New galactose #CRISPR screening strategy
🎯 481 genes required for #OXPHOS
⚙️ #FAM136A in IMS proteostasis
👂Mito defects in #Menieres disease
by @marcellharhai.bsky.social @fbm-unil.bsky.social
A short thread 1/5
www.biorxiv.org/content/10.1...
Reposted by Marcell Harhai
🔬 Curious about #mitochondria #imaging but unsure where to begin? Our review might help! 🚀📜🧪
www.annualreviews.org/content/jour...
#Quantitative #Microscopy #SuperResolution #AcademicSky #ScienceSky #CellBiology #mtDNA
www.annualreviews.org/content/jour...
#Quantitative #Microscopy #SuperResolution #AcademicSky #ScienceSky #CellBiology #mtDNA
November 17, 2024 at 4:46 PM
🔬 Curious about #mitochondria #imaging but unsure where to begin? Our review might help! 🚀📜🧪
www.annualreviews.org/content/jour...
#Quantitative #Microscopy #SuperResolution #AcademicSky #ScienceSky #CellBiology #mtDNA
www.annualreviews.org/content/jour...
#Quantitative #Microscopy #SuperResolution #AcademicSky #ScienceSky #CellBiology #mtDNA
🧪 ‼️
New preprint from the lab! 🚨
🧫 New galactose #CRISPR screening strategy
🎯 481 genes required for #OXPHOS
⚙️ #FAM136A in IMS proteostasis
👂Mito defects in #Menieres disease
by @marcellharhai.bsky.social @fbm-unil.bsky.social
A short thread 1/5
www.biorxiv.org/content/10.1...
🧫 New galactose #CRISPR screening strategy
🎯 481 genes required for #OXPHOS
⚙️ #FAM136A in IMS proteostasis
👂Mito defects in #Menieres disease
by @marcellharhai.bsky.social @fbm-unil.bsky.social
A short thread 1/5
www.biorxiv.org/content/10.1...
January 30, 2025 at 10:03 AM
🧪 ‼️
First PhD manuscript preprint OUT NOW! ‼️
🧫 New galactose #CRISPR screening strategy
📝 Updated OXPHOS-regulating gene inventory
🧬 #FAM136A in the IMS
👂 Mito defects in #Ménière’s disease
All come together in our latest work available at www.biorxiv.org/content/10.1...
🧫 New galactose #CRISPR screening strategy
📝 Updated OXPHOS-regulating gene inventory
🧬 #FAM136A in the IMS
👂 Mito defects in #Ménière’s disease
All come together in our latest work available at www.biorxiv.org/content/10.1...
January 30, 2025 at 10:02 AM
First PhD manuscript preprint OUT NOW! ‼️
🧫 New galactose #CRISPR screening strategy
📝 Updated OXPHOS-regulating gene inventory
🧬 #FAM136A in the IMS
👂 Mito defects in #Ménière’s disease
All come together in our latest work available at www.biorxiv.org/content/10.1...
🧫 New galactose #CRISPR screening strategy
📝 Updated OXPHOS-regulating gene inventory
🧬 #FAM136A in the IMS
👂 Mito defects in #Ménière’s disease
All come together in our latest work available at www.biorxiv.org/content/10.1...
Reposted by Marcell Harhai
Celebrating the New Year in style! Best wishes from the Jourdain Lab 🥌🫕🇨🇭
January 18, 2025 at 11:48 AM
Celebrating the New Year in style! Best wishes from the Jourdain Lab 🥌🫕🇨🇭
Exciting new work on mitos! 💫
Stoked to share TWO preprints on mitochondrial pearling! 🎉
We uncover how spontaneous #mitochondria pearling drives #mtDNA nucleoid distribution (doi.org/10.1101/2024...), and
@gavsturm.bsky.social
et al. dissect the biophysics behind it (doi.org/10.1101/2024...). Details below! 🔬🧵🧪
We uncover how spontaneous #mitochondria pearling drives #mtDNA nucleoid distribution (doi.org/10.1101/2024...), and
@gavsturm.bsky.social
et al. dissect the biophysics behind it (doi.org/10.1101/2024...). Details below! 🔬🧵🧪
December 23, 2024 at 4:43 PM
Exciting new work on mitos! 💫