@manueltard.bsky.social
Reposted
We have some awesome PhD studentships available at the BHF Centre of Research Excellence @vpd-hlri.bsky.social @cambridgeuni.bsky.social! Please do get in touch if interested.
Check them out here: www.jobs.cam.ac.uk/job/49483/
Application deadline: Jan 16th
Check them out here: www.jobs.cam.ac.uk/job/49483/
Application deadline: Jan 16th
BHF CRE interdisciplinary PhD studentships in cardiovascular sciences (non-clinical) - Job Opportunities - University of Cambridge
BHF CRE interdisciplinary PhD studentships in cardiovascular sciences (non-clinical) in the Department of Public Health and Primary Care at the University of Cambridge.
www.jobs.cam.ac.uk
December 6, 2024 at 12:28 PM
We have some awesome PhD studentships available at the BHF Centre of Research Excellence @vpd-hlri.bsky.social @cambridgeuni.bsky.social! Please do get in touch if interested.
Check them out here: www.jobs.cam.ac.uk/job/49483/
Application deadline: Jan 16th
Check them out here: www.jobs.cam.ac.uk/job/49483/
Application deadline: Jan 16th
Reposted
Just a reminder that you can add '-ai' to your google search and it will not show you any AI-generated overviews!
December 3, 2024 at 2:41 AM
Just a reminder that you can add '-ai' to your google search and it will not show you any AI-generated overviews!
Reposted
Serological evidence for SARS-CoV-2-like viruses in Sunda pangolins, likely reflecting the wildlife trade. Again exposes the idiocy of the "pangolin papers" accusations. I and others have even been accused of faking the pangolin data. bmcbiol.biomedcentral.com/articles/10....
Serological evidence of sarbecovirus exposure along Sunda pangolin trafficking pathways - BMC Biology
Background Early in the coronavirus disease 2019 (COVID-19) pandemic, Sunda pangolins (Manis javanica) involved in the illegal wildlife trade in mainland China were identified as hosts of severe acute...
bmcbiol.biomedcentral.com
November 28, 2024 at 12:41 AM
Serological evidence for SARS-CoV-2-like viruses in Sunda pangolins, likely reflecting the wildlife trade. Again exposes the idiocy of the "pangolin papers" accusations. I and others have even been accused of faking the pangolin data. bmcbiol.biomedcentral.com/articles/10....
Reposted
Atoms are binary. They are either intended to be hydrogen or helium. We can't just scrap this worldview just because of a handful of exceptions
November 28, 2024 at 1:02 PM
Atoms are binary. They are either intended to be hydrogen or helium. We can't just scrap this worldview just because of a handful of exceptions
Reposted
Vaccines work.
Cervical cancer mortality in US women younger than 25 years significantly declined between 2016 and 2021, likely due to the widespread adoption of HPV vaccination.
ja.ma/4i9ghPC
ja.ma/4i9ghPC
November 28, 2024 at 8:26 AM
Vaccines work.
Reposted
"From bacterial operons to gene therapy: 50 years of the journal Cell", by Tom Maniatis.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
From bacterial operons to gene therapy: 50 years of the journal Cell
Recombinant DNA technology has profoundly advanced virtually every aspect of biological
and medical sciences, from basic research to biotechnology. Here, I discuss conceptual
connections linking funda...
www.cell.com
November 18, 2024 at 4:49 PM
"From bacterial operons to gene therapy: 50 years of the journal Cell", by Tom Maniatis.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted
If you miss TweetDeck and other multicolumn apps and want a similarly good experience on BlueSky, @deck.blue is a really nice option (and the solo developer @gildaswise.com who built it is looking for work if anyone is hiring).
November 15, 2024 at 5:42 AM
If you miss TweetDeck and other multicolumn apps and want a similarly good experience on BlueSky, @deck.blue is a really nice option (and the solo developer @gildaswise.com who built it is looking for work if anyone is hiring).
Reposted
Alternative mRNA polyadenylation regulates macrophage hyperactivation via the autophagy pathway. #mRNA #PolyA #Adenylation #Macrophage #Genomics #BioSky #SciSky #CellularAndMolecularImmunology 🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Alternative mRNA polyadenylation regulates macrophage hyperactivation via the autophagy pathway - Cellular & Molecular Immunology
Cellular & Molecular Immunology - Alternative mRNA polyadenylation regulates macrophage hyperactivation via the autophagy pathway
www.nature.com
November 16, 2024 at 11:37 AM
Alternative mRNA polyadenylation regulates macrophage hyperactivation via the autophagy pathway. #mRNA #PolyA #Adenylation #Macrophage #Genomics #BioSky #SciSky #CellularAndMolecularImmunology 🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted
A thread with some new starter packs in genomics and bioinformatics 🧵 1/13...
November 15, 2024 at 9:56 AM
A thread with some new starter packs in genomics and bioinformatics 🧵 1/13...
Reposted
Looks quite useful! PharmFreq: a comprehensive atlas of ethnogeographic allelic variation in clinically important pharmacogenes. academic.oup.com/nar/advance-...
November 14, 2024 at 11:57 AM
Looks quite useful! PharmFreq: a comprehensive atlas of ethnogeographic allelic variation in clinically important pharmacogenes. academic.oup.com/nar/advance-...
Reposted
Every time I update my slides to talk about RNU4-2 / ReNU syndrome I have to update this screenshot. The group is growing so fast!
It is such a powerful and heartwarming demonstration of the importance of a genetic diagnosis to enable families to find community and support 🥹
It is such a powerful and heartwarming demonstration of the importance of a genetic diagnosis to enable families to find community and support 🥹
November 14, 2024 at 1:39 PM
Every time I update my slides to talk about RNU4-2 / ReNU syndrome I have to update this screenshot. The group is growing so fast!
It is such a powerful and heartwarming demonstration of the importance of a genetic diagnosis to enable families to find community and support 🥹
It is such a powerful and heartwarming demonstration of the importance of a genetic diagnosis to enable families to find community and support 🥹
Reposted
Regulation of transcription by condensates, great review by @bsabari.bsky.social and coll.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Transcription regulation by biomolecular condensates - Nature Reviews Molecular Cell Biology
Transcriptional condensates, which are formed through dynamic multivalent interactions between proteins, RNA and chromatin, regulate transcription by compartmentalizing its machinery in the crowded nu...
www.nature.com
November 13, 2024 at 6:56 PM
Regulation of transcription by condensates, great review by @bsabari.bsky.social and coll.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted
www.medrxiv.org/content/10.1...
Leveraging genetic ancestry continuum information to interpolate PRS for admixed populations
@pnatarajanmd.bsky.social group presents DiscoDivas, a generalizable polygenic risk score framework across the continuous genetic ancestry spectrum
Leveraging genetic ancestry continuum information to interpolate PRS for admixed populations
@pnatarajanmd.bsky.social group presents DiscoDivas, a generalizable polygenic risk score framework across the continuous genetic ancestry spectrum
Leveraging genetic ancestry continuum information to interpolate PRS for admixed populations
Calculating optimal polygenic risk scores (PRS) across diverse ancestries, particularly in admixed populations, is necessary to enable equitable genetic research and clinical translation. However, the...
www.medrxiv.org
November 11, 2024 at 6:41 PM
www.medrxiv.org/content/10.1...
Leveraging genetic ancestry continuum information to interpolate PRS for admixed populations
@pnatarajanmd.bsky.social group presents DiscoDivas, a generalizable polygenic risk score framework across the continuous genetic ancestry spectrum
Leveraging genetic ancestry continuum information to interpolate PRS for admixed populations
@pnatarajanmd.bsky.social group presents DiscoDivas, a generalizable polygenic risk score framework across the continuous genetic ancestry spectrum
Reposted
A consensus variant-to-function score to functionally prioritize variants for disease
www.biorxiv.org/content/10.1...
Great work by Kushal Dey's lab on an ensemble approach that integrates diverse V2F scores to prioritize causal variants in GWAS loci. #ENCODE4
www.biorxiv.org/content/10.1...
Great work by Kushal Dey's lab on an ensemble approach that integrates diverse V2F scores to prioritize causal variants in GWAS loci. #ENCODE4
A consensus variant-to-function score to functionally prioritize variants for disease
Identifying and functionally characterizing causal disease variants in genome-wide association studies remains a pressing challenge. Here, we construct a consensus variant-to-function (cV2F) score tha...
www.biorxiv.org
November 11, 2024 at 6:35 PM
A consensus variant-to-function score to functionally prioritize variants for disease
www.biorxiv.org/content/10.1...
Great work by Kushal Dey's lab on an ensemble approach that integrates diverse V2F scores to prioritize causal variants in GWAS loci. #ENCODE4
www.biorxiv.org/content/10.1...
Great work by Kushal Dey's lab on an ensemble approach that integrates diverse V2F scores to prioritize causal variants in GWAS loci. #ENCODE4
Reposted
These bluesky starter packs are a great idea. Welcome to all new followers!
If ur unfamiliar with our lab, we do a lot in human genomics & bioinformatics (polygenic scores & disease risk, multi-omics for aetiology, software/resources for the community)
Check out www.inouyelab.org/home/publica...
If ur unfamiliar with our lab, we do a lot in human genomics & bioinformatics (polygenic scores & disease risk, multi-omics for aetiology, software/resources for the community)
Check out www.inouyelab.org/home/publica...
Inouye Lab - Publications
Google Scholar
Inouye Lab authors
* denotes equal contribution
www.inouyelab.org
November 7, 2024 at 10:20 AM
These bluesky starter packs are a great idea. Welcome to all new followers!
If ur unfamiliar with our lab, we do a lot in human genomics & bioinformatics (polygenic scores & disease risk, multi-omics for aetiology, software/resources for the community)
Check out www.inouyelab.org/home/publica...
If ur unfamiliar with our lab, we do a lot in human genomics & bioinformatics (polygenic scores & disease risk, multi-omics for aetiology, software/resources for the community)
Check out www.inouyelab.org/home/publica...
Reposted
This is a beautiful paper led by Christel Depienne and Caroline Nava, further characterising ReNU syndrome (caused by variants in the snRNA RNU4-2) and identifying the role of RNU5B-1 in neurodevelopmental disorders: www.medrxiv.org/content/10.1...
🧬🖥️ #RNAbiology
Some highlights 🧵
🧬🖥️ #RNAbiology
Some highlights 🧵
Dominant variants in major spliceosome U4 and U5 small nuclear RNA genes cause neurodevelopmental disorders through splicing disruption
Variants in RNU4-2, encoding the small nuclear RNA (snRNA) U4, were recently identified as a major cause of neurodevelopmental disorders (ReNU syndrome). Here, we investigated de novo variants in 50 s...
www.medrxiv.org
October 9, 2024 at 9:37 AM
This is a beautiful paper led by Christel Depienne and Caroline Nava, further characterising ReNU syndrome (caused by variants in the snRNA RNU4-2) and identifying the role of RNU5B-1 in neurodevelopmental disorders: www.medrxiv.org/content/10.1...
🧬🖥️ #RNAbiology
Some highlights 🧵
🧬🖥️ #RNAbiology
Some highlights 🧵
Reposted
The Polygenic Score Catalog (www.pgscatalog.org) is an open resource for the global community
Check out how we've made PGSs even more Findable, Accessible, Interoperable and Re-usable (FAIR), including a new PGS calculator with ancestry normalisation www.nature.com/articles/s41...
Check out how we've made PGSs even more Findable, Accessible, Interoperable and Re-usable (FAIR), including a new PGS calculator with ancestry normalisation www.nature.com/articles/s41...
PGS Catalog - The Polygenic Score Catalog
The Polygenic Score (PGS) Catalog is an open database of
published PGS and the relevant metadata needed to apply and evaluate them correctly.
pgscatalog.org
October 2, 2024 at 6:42 PM
The Polygenic Score Catalog (www.pgscatalog.org) is an open resource for the global community
Check out how we've made PGSs even more Findable, Accessible, Interoperable and Re-usable (FAIR), including a new PGS calculator with ancestry normalisation www.nature.com/articles/s41...
Check out how we've made PGSs even more Findable, Accessible, Interoperable and Re-usable (FAIR), including a new PGS calculator with ancestry normalisation www.nature.com/articles/s41...