Jeremy Luban 🧬🦠🔬🩺🎸🎻
@lubanlab.bsky.social
Scientist/Professor/Physician/Musician
Serendipity & absurdity
Serendipity & absurdity
Reposted by Jeremy Luban 🧬🦠🔬🩺🎸🎻
I am thrilled to share our story online at @cellpress.bsky.social . Big thanks to all authors: Zhiping, Bill, @lubanlab.bsky.social, Keith & bluesky-less!
authors.elsevier.com/c/1kjdaL7PXu...
How to tame a genome invader? It takes wild koalas 🐨🐨 to learn it.
#Retrovirus #koala #piRNA
More below 👇
authors.elsevier.com/c/1kjdaL7PXu...
How to tame a genome invader? It takes wild koalas 🐨🐨 to learn it.
#Retrovirus #koala #piRNA
More below 👇
March 9, 2025 at 2:35 AM
I am thrilled to share our story online at @cellpress.bsky.social . Big thanks to all authors: Zhiping, Bill, @lubanlab.bsky.social, Keith & bluesky-less!
authors.elsevier.com/c/1kjdaL7PXu...
How to tame a genome invader? It takes wild koalas 🐨🐨 to learn it.
#Retrovirus #koala #piRNA
More below 👇
authors.elsevier.com/c/1kjdaL7PXu...
How to tame a genome invader? It takes wild koalas 🐨🐨 to learn it.
#Retrovirus #koala #piRNA
More below 👇
Reposted by Jeremy Luban 🧬🦠🔬🩺🎸🎻
Keep speaking up because it matters. Call out inhumane policies that will kill people. PEPFAR funded HIV drug distribution resumes...for now.
www.nytimes.com/2025/01/28/h...
www.nytimes.com/2025/01/28/h...
State Department Permits Distribution of H.I.V. Medications to Resume — for Now (Gift Article)
Experts fear a resurgence of infections in low-income countries if the ban were to continue. The waiver remains in place, while officials review foreign aid programs.
www.nytimes.com
January 29, 2025 at 9:15 AM
Keep speaking up because it matters. Call out inhumane policies that will kill people. PEPFAR funded HIV drug distribution resumes...for now.
www.nytimes.com/2025/01/28/h...
www.nytimes.com/2025/01/28/h...
Reposted by Jeremy Luban 🧬🦠🔬🩺🎸🎻
Reposted by Jeremy Luban 🧬🦠🔬🩺🎸🎻
Lots of new viruses (and other known pathogens) here, especially in carnivores and rodents. Of most interest, a bi-segmented coronavirus sampled from diseased red (lesser) pandas (Ailurus fulgens) and that represents a new genus. Work led my Mang Shi and Shuo Su. www.biorxiv.org/content/10.1...
www.biorxiv.org
January 11, 2025 at 7:02 AM
Lots of new viruses (and other known pathogens) here, especially in carnivores and rodents. Of most interest, a bi-segmented coronavirus sampled from diseased red (lesser) pandas (Ailurus fulgens) and that represents a new genus. Work led my Mang Shi and Shuo Su. www.biorxiv.org/content/10.1...
Reposted by Jeremy Luban 🧬🦠🔬🩺🎸🎻
Five years ago (Saturday 11 Jan 2020), first public announcement and availability of a sequence of the new coronavirus.
It was posted by @eddieholmes.bsky.social at 01:05 UTC on Virological, and announced on Twitter at 01:08 UTC. ▫️1/
web.archive.org/web/20200118...
archive.is/z880d
It was posted by @eddieholmes.bsky.social at 01:05 UTC on Virological, and announced on Twitter at 01:08 UTC. ▫️1/
web.archive.org/web/20200118...
archive.is/z880d
![screenshot of Eddie Holmes' tweet:
@edwardcholmes
All, an initial genome sequence of the coronavirus associated with the Wuhan outbreak is now available at Virological.org here: [link to virological]](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:yqxcc5ayxllwkvel4narbha4/bafkreif5tqxzjq4jcbdixilkvf74b626h34s2voszstutwib2wgtk5wkqa@jpeg)
January 11, 2025 at 1:05 AM
Five years ago (Saturday 11 Jan 2020), first public announcement and availability of a sequence of the new coronavirus.
It was posted by @eddieholmes.bsky.social at 01:05 UTC on Virological, and announced on Twitter at 01:08 UTC. ▫️1/
web.archive.org/web/20200118...
archive.is/z880d
It was posted by @eddieholmes.bsky.social at 01:05 UTC on Virological, and announced on Twitter at 01:08 UTC. ▫️1/
web.archive.org/web/20200118...
archive.is/z880d
Recently:
- a severe case of H5N1 infection in British Columbia (required ICU, now recovered)
- a lethal case in Louisiana.
Features of the Flu sequences from both patients:
- closest to flu found in birds
- HA mutations likely to be adaptations to humans
www.cdc.gov/bird-flu/spo...
- a severe case of H5N1 infection in British Columbia (required ICU, now recovered)
- a lethal case in Louisiana.
Features of the Flu sequences from both patients:
- closest to flu found in birds
- HA mutations likely to be adaptations to humans
www.cdc.gov/bird-flu/spo...
Genetic Sequences of Highly Pathogenic Avian Influenza A(H5N1) Viruses Identified in a Person in Louisiana
CDC has sequenced the influenza viruses in specimens collected from the patient in Louisiana who was
www.cdc.gov
January 6, 2025 at 11:42 PM
Recently:
- a severe case of H5N1 infection in British Columbia (required ICU, now recovered)
- a lethal case in Louisiana.
Features of the Flu sequences from both patients:
- closest to flu found in birds
- HA mutations likely to be adaptations to humans
www.cdc.gov/bird-flu/spo...
- a severe case of H5N1 infection in British Columbia (required ICU, now recovered)
- a lethal case in Louisiana.
Features of the Flu sequences from both patients:
- closest to flu found in birds
- HA mutations likely to be adaptations to humans
www.cdc.gov/bird-flu/spo...
Reposted by Jeremy Luban 🧬🦠🔬🩺🎸🎻
Five years ago (Sunday 5 Jan 2020), scientists in Zhang YongZhen's group in Shanghai obtained their first sequence of the new virus, from samples obtained outside of the official national protocol.
They submitted it to GenBank with an embargo. ▫️1/
www.ncbi.nlm.nih.gov/nuccore/MN90...
They submitted it to GenBank with an embargo. ▫️1/
www.ncbi.nlm.nih.gov/nuccore/MN90...
January 5, 2025 at 9:03 AM
Five years ago (Sunday 5 Jan 2020), scientists in Zhang YongZhen's group in Shanghai obtained their first sequence of the new virus, from samples obtained outside of the official national protocol.
They submitted it to GenBank with an embargo. ▫️1/
www.ncbi.nlm.nih.gov/nuccore/MN90...
They submitted it to GenBank with an embargo. ▫️1/
www.ncbi.nlm.nih.gov/nuccore/MN90...
Reposted by Jeremy Luban 🧬🦠🔬🩺🎸🎻
“The beauty of mRNA is the ability within a moment’s notice to change the vaccine.”
time.com/7203820/h5n1...
time.com/7203820/h5n1...
Scientists Are Racing to Develop a New Bird Flu Vaccine
The most promising approach uses mRNA.
time.com
January 5, 2025 at 4:33 PM
“The beauty of mRNA is the ability within a moment’s notice to change the vaccine.”
time.com/7203820/h5n1...
time.com/7203820/h5n1...
Reposted by Jeremy Luban 🧬🦠🔬🩺🎸🎻
The Outbreak of human metapneumovirus in China has caused a bit of a stir . It is not a novel virus but seems to be causing a significant outbreak coinciding with the winter. HMPV, was discovered in 2001 in the Netherlands.
www.newsweek.com/human-metapn...
www.newsweek.com/human-metapn...
HMPV: China's new virus outbreak explained
As reports of a new virus outbreak circulate, here is everything you need to know about human metapneumovirus (HMPV).
www.newsweek.com
January 5, 2025 at 8:51 PM
The Outbreak of human metapneumovirus in China has caused a bit of a stir . It is not a novel virus but seems to be causing a significant outbreak coinciding with the winter. HMPV, was discovered in 2001 in the Netherlands.
www.newsweek.com/human-metapn...
www.newsweek.com/human-metapn...
Reposted by Jeremy Luban 🧬🦠🔬🩺🎸🎻
Do you know where transcription of a gene actually stops? Hint: it is not the annotated gene end.
In our new paper in Nucleic Acids Research we argue that phosphorylation on threonine 4 of RNA Pol II CTD is a marker of transcription termination in animals... 🧵
academic.oup.com/nar/advance-...
In our new paper in Nucleic Acids Research we argue that phosphorylation on threonine 4 of RNA Pol II CTD is a marker of transcription termination in animals... 🧵
academic.oup.com/nar/advance-...
December 27, 2024 at 4:01 PM
Do you know where transcription of a gene actually stops? Hint: it is not the annotated gene end.
In our new paper in Nucleic Acids Research we argue that phosphorylation on threonine 4 of RNA Pol II CTD is a marker of transcription termination in animals... 🧵
academic.oup.com/nar/advance-...
In our new paper in Nucleic Acids Research we argue that phosphorylation on threonine 4 of RNA Pol II CTD is a marker of transcription termination in animals... 🧵
academic.oup.com/nar/advance-...
Case report of 13 year old in British Columbia with H5N1 infection. Progression in one day from left-sided pneumonia to complete lung involvement (see chest x-rays)
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
January 2, 2025 at 1:02 AM
Case report of 13 year old in British Columbia with H5N1 infection. Progression in one day from left-sided pneumonia to complete lung involvement (see chest x-rays)
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Cool paper on broadening anti-influenza immune response to vax:
- human data: twins, newborns, & tonsil organoid; & mouse data
- Host genetics > original antigenic sin
- Covalent coupling of diverse HAs decreases anti-HA antibody strain bias, probably via T cell help
www.science.org/doi/pdf/10.1...
- human data: twins, newborns, & tonsil organoid; & mouse data
- Host genetics > original antigenic sin
- Covalent coupling of diverse HAs decreases anti-HA antibody strain bias, probably via T cell help
www.science.org/doi/pdf/10.1...
Coupling antigens from multiple subtypes of influenza can broaden antibody and T cell responses
The seasonal influenza vaccine contains strains of viruses from distinct subtypes that are grown independently and then combined. However, most individuals exhibit a more robust response to one of the...
www.science.org
December 31, 2024 at 10:31 AM
Cool paper on broadening anti-influenza immune response to vax:
- human data: twins, newborns, & tonsil organoid; & mouse data
- Host genetics > original antigenic sin
- Covalent coupling of diverse HAs decreases anti-HA antibody strain bias, probably via T cell help
www.science.org/doi/pdf/10.1...
- human data: twins, newborns, & tonsil organoid; & mouse data
- Host genetics > original antigenic sin
- Covalent coupling of diverse HAs decreases anti-HA antibody strain bias, probably via T cell help
www.science.org/doi/pdf/10.1...
Reposted by Jeremy Luban 🧬🦠🔬🩺🎸🎻
Five years ago (Monday 30 Dec 2019), a turning point: the news of an outbreak in Wuhan spread on messaging apps, social media (Weibo, then Twitter), and got out of China, culminating with a ProMED alert sent to the international medical community on 30-31 Dec. ▫️1/
December 30, 2024 at 9:08 AM
Five years ago (Monday 30 Dec 2019), a turning point: the news of an outbreak in Wuhan spread on messaging apps, social media (Weibo, then Twitter), and got out of China, culminating with a ProMED alert sent to the international medical community on 30-31 Dec. ▫️1/
Reposted by Jeremy Luban 🧬🦠🔬🩺🎸🎻
I’m looking for a postdoc to join my team under a recently funded ERC Starting Grant.
If you’re passionate about structural #virology and have experience in #cryoEM SPA and/or #cryoET, get in touch!
Application deadline: January 19th.
Please share with your networks 🙏
Job link: tiny.cc/7v33001
If you’re passionate about structural #virology and have experience in #cryoEM SPA and/or #cryoET, get in touch!
Application deadline: January 19th.
Please share with your networks 🙏
Job link: tiny.cc/7v33001
Postdoctoral Researcher in Structural Virology
This project is focused on deciphering the role of virally encoded AAA+ ATPases in the replication cycles of Enteroviruses and Noroviruses.
tiny.cc
December 27, 2024 at 7:59 AM
I’m looking for a postdoc to join my team under a recently funded ERC Starting Grant.
If you’re passionate about structural #virology and have experience in #cryoEM SPA and/or #cryoET, get in touch!
Application deadline: January 19th.
Please share with your networks 🙏
Job link: tiny.cc/7v33001
If you’re passionate about structural #virology and have experience in #cryoEM SPA and/or #cryoET, get in touch!
Application deadline: January 19th.
Please share with your networks 🙏
Job link: tiny.cc/7v33001
Reposted by Jeremy Luban 🧬🦠🔬🩺🎸🎻
1/ 🎄 What’s the best gift under the tree for a computational biologist? 🎁 A new experimental assay that refines our view of gene regulation: ACCESS-ATAC! This creative idea from Richard Sherwood was developed collaboratively between his lab and mine. #Genomics
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
December 23, 2024 at 3:18 PM
1/ 🎄 What’s the best gift under the tree for a computational biologist? 🎁 A new experimental assay that refines our view of gene regulation: ACCESS-ATAC! This creative idea from Richard Sherwood was developed collaboratively between his lab and mine. #Genomics
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Jeremy Luban 🧬🦠🔬🩺🎸🎻
You don't say...
The price of eggs will define 2025. I am calling it 😏
www.theguardian.com/us-news/2024...
The price of eggs will define 2025. I am calling it 😏
www.theguardian.com/us-news/2024...
Egg prices soar as bird flu takes toll on US hen flock
Average price of eggs rose nearly 30 cents since October, with egg production down 4% from prior year
www.theguardian.com
December 21, 2024 at 5:44 PM
You don't say...
The price of eggs will define 2025. I am calling it 😏
www.theguardian.com/us-news/2024...
The price of eggs will define 2025. I am calling it 😏
www.theguardian.com/us-news/2024...
Thomas Pindani Nyalile defended his Ph.D. thesis today:
"Regulation of HIV-1 gene expression, provirus reactivation, and replication dynamics by EIF3H"
Congrats Dr. Nyalile!!!
Next Spring he'll be heading back to Tanzania to do some molecular biology:
"Regulation of HIV-1 gene expression, provirus reactivation, and replication dynamics by EIF3H"
Congrats Dr. Nyalile!!!
Next Spring he'll be heading back to Tanzania to do some molecular biology:
December 19, 2024 at 9:41 PM
Thomas Pindani Nyalile defended his Ph.D. thesis today:
"Regulation of HIV-1 gene expression, provirus reactivation, and replication dynamics by EIF3H"
Congrats Dr. Nyalile!!!
Next Spring he'll be heading back to Tanzania to do some molecular biology:
"Regulation of HIV-1 gene expression, provirus reactivation, and replication dynamics by EIF3H"
Congrats Dr. Nyalile!!!
Next Spring he'll be heading back to Tanzania to do some molecular biology:
It is a first such case in the US, and of course scary, especially for the patient, but not a harbinger of a change in the virus. The person had exposure to sick birds. This is not infection with the dairy cow virus.
www.cdc.gov/media/releas...
www.cdc.gov/media/releas...
CDC Confirms First Severe Case of H5N1 Bird Flu in the United States
December 18, 2024-- A patient has been hospitalized with a severe case of avian influenza A(H5N1)
www.cdc.gov
December 18, 2024 at 5:52 PM
It is a first such case in the US, and of course scary, especially for the patient, but not a harbinger of a change in the virus. The person had exposure to sick birds. This is not infection with the dairy cow virus.
www.cdc.gov/media/releas...
www.cdc.gov/media/releas...
We discovered the source of the super high tech multicolored drones:
Veggie Galaxy on Mass Ave near MIT (so obvious once you think of it)
Veggie Galaxy on Mass Ave near MIT (so obvious once you think of it)
December 15, 2024 at 5:00 AM
We discovered the source of the super high tech multicolored drones:
Veggie Galaxy on Mass Ave near MIT (so obvious once you think of it)
Veggie Galaxy on Mass Ave near MIT (so obvious once you think of it)
~40 non-human primates have their own SIVs/lentis/immunodef viruses. For ex, SIVsyke’s monkey, or SIVmandrill, all structurally similar to HIV-1
The ICTV Lentivirus classification is flawed. Lentivirus humimdef1 (HIV-1) is not monophyletic (i.e. multiple jumps), nor is Lentivirus simimdef (SIV), and whereas HIV-1 has a single host and originated quite recently, SIV infects diverse primate species and is 1000s of years old. AKA inconsistent.
Genus: Lentivirus | ICTV
ictv.global
December 14, 2024 at 7:49 PM
~40 non-human primates have their own SIVs/lentis/immunodef viruses. For ex, SIVsyke’s monkey, or SIVmandrill, all structurally similar to HIV-1
Reposted by Jeremy Luban 🧬🦠🔬🩺🎸🎻
The ICTV Lentivirus classification is flawed. Lentivirus humimdef1 (HIV-1) is not monophyletic (i.e. multiple jumps), nor is Lentivirus simimdef (SIV), and whereas HIV-1 has a single host and originated quite recently, SIV infects diverse primate species and is 1000s of years old. AKA inconsistent.
Genus: Lentivirus | ICTV
ictv.global
December 14, 2024 at 7:54 AM
The ICTV Lentivirus classification is flawed. Lentivirus humimdef1 (HIV-1) is not monophyletic (i.e. multiple jumps), nor is Lentivirus simimdef (SIV), and whereas HIV-1 has a single host and originated quite recently, SIV infects diverse primate species and is 1000s of years old. AKA inconsistent.
Reposted by Jeremy Luban 🧬🦠🔬🩺🎸🎻
Here is why it is incorrect to blame the US response to the #H5N1 outbreak in dairy cattle for the human case in British Columbia: they are unrelated.
H5N1 is diverse, and the genotype involved in the dairy cattle outbreak is not the same as the one collected in BC
nextstrain.org/avian-flu/h5...
H5N1 is diverse, and the genotype involved in the dairy cattle outbreak is not the same as the one collected in BC
nextstrain.org/avian-flu/h5...
December 5, 2024 at 4:30 PM
Here is why it is incorrect to blame the US response to the #H5N1 outbreak in dairy cattle for the human case in British Columbia: they are unrelated.
H5N1 is diverse, and the genotype involved in the dairy cattle outbreak is not the same as the one collected in BC
nextstrain.org/avian-flu/h5...
H5N1 is diverse, and the genotype involved in the dairy cattle outbreak is not the same as the one collected in BC
nextstrain.org/avian-flu/h5...
Reposted by Jeremy Luban 🧬🦠🔬🩺🎸🎻
Agree! Huge scientific breakthrough - now we need global access to see the real change happen!
Science’s 2024 Breakthrough of the Year is lenacapavir, an injectable drug that demonstrated remarkable success at preventing HIV infection with one shot every 6 months.
Learn more about this year's #BOTY and other big advances in science: scim.ag/3BrCtUn
Learn more about this year's #BOTY and other big advances in science: scim.ag/3BrCtUn
December 12, 2024 at 7:57 PM
Agree! Huge scientific breakthrough - now we need global access to see the real change happen!
Video recording of 2024 MassCPR Symposium is online
Yoshihiro Kawaoka, Eva Harris, JJ Stone, David Bean, Shira Weingarten-Gabbay, Wanyu Li, Milky Abajorga, Erika Weiskopf
UMadison/Tokyo, Berkeley, UMass, Harvard, Tufts, Boston Univ, MIT, Broad
masscpr.hms.harvard.edu/masscpr-symp...
Yoshihiro Kawaoka, Eva Harris, JJ Stone, David Bean, Shira Weingarten-Gabbay, Wanyu Li, Milky Abajorga, Erika Weiskopf
UMadison/Tokyo, Berkeley, UMass, Harvard, Tufts, Boston Univ, MIT, Broad
masscpr.hms.harvard.edu/masscpr-symp...
2024 MassCPR Symposium | Massachusetts Consortium on Pathogen Readiness
masscpr.hms.harvard.edu
December 13, 2024 at 3:31 PM
Video recording of 2024 MassCPR Symposium is online
Yoshihiro Kawaoka, Eva Harris, JJ Stone, David Bean, Shira Weingarten-Gabbay, Wanyu Li, Milky Abajorga, Erika Weiskopf
UMadison/Tokyo, Berkeley, UMass, Harvard, Tufts, Boston Univ, MIT, Broad
masscpr.hms.harvard.edu/masscpr-symp...
Yoshihiro Kawaoka, Eva Harris, JJ Stone, David Bean, Shira Weingarten-Gabbay, Wanyu Li, Milky Abajorga, Erika Weiskopf
UMadison/Tokyo, Berkeley, UMass, Harvard, Tufts, Boston Univ, MIT, Broad
masscpr.hms.harvard.edu/masscpr-symp...