Chronic kidney disease (CKD) affects about 850 million people worldwide and is a leading cause of illness and death.1 Patients with advanced CKD, especially in stage 5, face higher risks of drug toxic...

Presented by Laurent Mesnard Article DOI: https://doi.org/10.1093/ndt/gfaf138

Thomas Robert, Mathieu Georget, Yannis Lombardi, Laurent Mesnard; CKDx: a necessary step—but can we go further?, Nephrology Dialysis Transplantation, , gfa

Nature Reviews Nephrology, Published online: 16 June 2025; doi:10.1038/s41581-025-00970-1This Review examines the use of pangenomic analysis to improve molecular diagnoses in adult nephrology, including available sequencing methods and their applications. The authors also discuss current barriers to translating genetic information into actionable diagnoses, ethical challenges and the key role of multidisciplinary collaboration.

Most genomics research cohorts are made up of participants of European ancestry, which limits the reach of precision medicine. Here, the authors describe the genetic diversity in the All of Us research program, which is enriched in underrepresented ancestries.

udy, an unselected health system-based cohort with exome sequencing and electronic health records. Patients with COL4A5 variants reported as pathogenic or likely pathogenic in ClinVar, or protein-trun...