Alejandro Llorente, Ph.D.
@llorentealejandro.bsky.social
Postdoctoral fellow at Columbia University.
Working on structural biology and protein engineering at the laboratory of Dr. Oliver Clark
Working on structural biology and protein engineering at the laboratory of Dr. Oliver Clark
1/9 🚀 Big news! As a result of 5 years of my PhD, building on a 30-year dream of my PI Dr. Nancy Carrasco, we think we've found a new way to treat cancer! We’ve released our preprint & I'm so excited to share this story! 🧵
www.biorxiv.org/content/10.1...
#Science #proteinengineering #proteindesing
www.biorxiv.org/content/10.1...
#Science #proteinengineering #proteindesing
Engineering substrate selectivity in the human sodium/iodide symporter (NIS)
Iodide (I-) uptake mediated by the Na+/I- symporter (NIS) is the first step in the biosynthesis of the thyroid hormones, of which I- is an essential constituent. NIS couples the inward transport of I-...
www.biorxiv.org
October 9, 2025 at 2:43 AM
1/9 🚀 Big news! As a result of 5 years of my PhD, building on a 30-year dream of my PI Dr. Nancy Carrasco, we think we've found a new way to treat cancer! We’ve released our preprint & I'm so excited to share this story! 🧵
www.biorxiv.org/content/10.1...
#Science #proteinengineering #proteindesing
www.biorxiv.org/content/10.1...
#Science #proteinengineering #proteindesing
Cleaning my backyard❤️
September 14, 2025 at 11:25 PM
Cleaning my backyard❤️
Reposted by Alejandro Llorente, Ph.D.
This one is a bit of a departure from the usual and definitely a work in progress!
We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.
Read on for details... 1/x
We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.
Read on for details... 1/x
September 13, 2025 at 12:05 AM
This one is a bit of a departure from the usual and definitely a work in progress!
We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.
Read on for details... 1/x
We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.
Read on for details... 1/x
Reposted by Alejandro Llorente, Ph.D.
High-resolution ab initio reconstruction enables cryo-EM structure determination of small particles https://www.biorxiv.org/content/10.1101/2025.09.08.674935v1
September 12, 2025 at 10:47 PM
High-resolution ab initio reconstruction enables cryo-EM structure determination of small particles https://www.biorxiv.org/content/10.1101/2025.09.08.674935v1
Reposted by Alejandro Llorente, Ph.D.
9/x To read more, check out our preprint, first author @huanli00.bsky.social: www.biorxiv.org/content/10.1...
The vault particle is enclosed by a C13-symmetric cap with a positively charged exterior
Vaults are some of the largest ribonucleoprotein complexes known, and are highly conserved across eukaryotes, but both their function and key details of their architecture remain unclear. While high-r...
www.biorxiv.org
June 12, 2025 at 1:44 PM
9/x To read more, check out our preprint, first author @huanli00.bsky.social: www.biorxiv.org/content/10.1...
Reposted by Alejandro Llorente, Ph.D.
I know there are more important things to worry about right now... but it really pisses me off coming across things like this in the literature.
Nominally 4.8 Å map... check out Fig S1 😬
(also check out any other #cryoem paper by same group, ~all in BBRC)
www.sciencedirect.com/science/arti...
Nominally 4.8 Å map... check out Fig S1 😬
(also check out any other #cryoem paper by same group, ~all in BBRC)
www.sciencedirect.com/science/arti...
April 10, 2025 at 2:25 PM
I know there are more important things to worry about right now... but it really pisses me off coming across things like this in the literature.
Nominally 4.8 Å map... check out Fig S1 😬
(also check out any other #cryoem paper by same group, ~all in BBRC)
www.sciencedirect.com/science/arti...
Nominally 4.8 Å map... check out Fig S1 😬
(also check out any other #cryoem paper by same group, ~all in BBRC)
www.sciencedirect.com/science/arti...
Hi all, I am happy to be now in a much more inclusive place ❤️🏳️🌈🔬
January 28, 2025 at 3:40 PM
Hi all, I am happy to be now in a much more inclusive place ❤️🏳️🌈🔬