A warm welcome to our new PhD student Emma Lautenbach, who will work on the intricacies of the podosome cap 🧢

A warm welcome to our new lab member Canberk Yesilada, who will be/is already working on his PhD thesis on Borrelia phagocytosis by macrophages 🤗

Macrophages are super!
SoRA (superresolution after optical reassignment) microscopy video of a primary human macrophage transfected with Lifeact-GFP to visualize actin-rich podosomes.
Star-like appearance is due to connecting cables linking individual podosomes into a cell-wide superstructure ✨

On our way to Heidelberg to the meeting of the German Society for Cell Biology 🧫

New preprint:
Phagocytic podosomes enable efficient uptake of Candida auris by primary human macrophages 🦠👄
www.biorxiv.org/content/10.1...

Our paper on podosome regulation by myosins 1e/f is now online.
We introduce the concept of the podosome base, a region of plasma membrane-associated components 🔬
Cool collaboration with @renaudpoincloux.bsky.social‬ and Krendel labs
www.sciencedirect.com/science/arti...

Congratulations to our lab member Bryan Barcelona to a super fancy defense on software-based analysis of cell and podosome parameters 👨‍🎓

Cellular fireworks
(in a primary human macrophage):
Microtubule +tips, labeled by CLIP170-GFP, move from the microtubule organizing center (MTOC) to the cell periphery ✨

A warm welcome to our new master student Mahmood Tarmom, who will work on podosome proteins of (yet) unknown function 🔬

Coming up: "Live Biological Imaging Across Scales", part of the Royal Microscopic Society line of Wiley books.
Featuring 10 chapters from international experts on live imaging from molecules to organisms.
Edited by Claire M. Wells and yours truly 📘🧬🐭

Our preprint on podosome regulation by unconventional myosins in now on BioRxiv. Great collaboration with the @renaudpoincloux.bsky.social and Krendel labs.
www.biorxiv.org/content/10.1...

We introduce the concept of the "podosome base", a region of plasma membrane-associated podosome components.

Upcoming meeting:
11th Trippenhuis meeting of the Dutch Society for Cell Biology
(Amsterdam, May 8-9) 🏠

Farewell sushi dinner for our longtime assistant Andrea who is now retiring 🥲🍣

Congratulations to our lab member Rawan Batlouni for an excellent MD thesis on phagocytic podosomes 👨‍🎓

A warm welcome to our new MD student Fan Yang, who will work on Borrelia-macrophage interaction 🤗

Video of a FIB-SEM analysed macrophage phagosome containing a single Borrelia cell being compacted by membrane tubulation, leading to reduction of the phagosome volume.
Phagosome membrane in blue, Borrelia in turquoise. Watch for start of transparency mid-video 🪱
pubmed.ncbi.nlm.nih.gov/33380490/