Lieber Institute for Brain Development
@lieberinstitute.bsky.social
Changing the lives of people with schizophrenia and related mental illnesses. Learn more about our research at www.libd.org.
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Interested in learning directly from our scientists and alumni? 🤩
Here is our members and alumni starter pack. As Bluesky says: join the conversation! Click under “posts” to see their 💯 work!
📣 Help us get more members & alumni on the list!
#Neuroscience #AcademicSky
🔗 go.bsky.app/VhR2e62
Here is our members and alumni starter pack. As Bluesky says: join the conversation! Click under “posts” to see their 💯 work!
📣 Help us get more members & alumni on the list!
#Neuroscience #AcademicSky
🔗 go.bsky.app/VhR2e62
Reposted by Lieber Institute for Brain Development
For #FluorescenceFriday - one of my favorites from the archives of a neuron ⚪ and astrocyte 🟢 co-culture. Image credit to Stephanie Page and former research assistant Beth Pattie 🧠🔬🧪
November 7, 2025 at 12:37 PM
For #FluorescenceFriday - one of my favorites from the archives of a neuron ⚪ and astrocyte 🟢 co-culture. Image credit to Stephanie Page and former research assistant Beth Pattie 🧠🔬🧪
Reposted by Lieber Institute for Brain Development
Our lateral septum (LS) team is representing for #SfN25! We have two posters on Wed afternoon from RA Madeline Abramson (PSTR463.16) and undergraduate Yufeng Du (PSTR463.17) showcasing newest molecular profiling results across mouse, non-human primate and human 🧠
I'm there too - get in touch!
I'm there too - get in touch!
November 14, 2025 at 4:11 PM
Our lateral septum (LS) team is representing for #SfN25! We have two posters on Wed afternoon from RA Madeline Abramson (PSTR463.16) and undergraduate Yufeng Du (PSTR463.17) showcasing newest molecular profiling results across mouse, non-human primate and human 🧠
I'm there too - get in touch!
I'm there too - get in touch!
Reposted by Lieber Institute for Brain Development
Me lurking in people's folders on the server for #FluorescenceFriday. Image is so fresh off the scope that I don't even know what it is so I can't even tell you what the channels are - but, somebody (RA Jason Rehg) is doing something in the VTA and whatever it is, it looks super cool 🤩🧠🔬🧪
November 14, 2025 at 8:40 PM
Me lurking in people's folders on the server for #FluorescenceFriday. Image is so fresh off the scope that I don't even know what it is so I can't even tell you what the channels are - but, somebody (RA Jason Rehg) is doing something in the VTA and whatever it is, it looks super cool 🤩🧠🔬🧪
Reposted by Lieber Institute for Brain Development
Hot take: ggplot2 is better than any plotting option available in Python-- but I discuss a couple options in Python at an R Stats Club session @libdrstats.bsky.social linked below. I personally use plotnine, since it's essentially a port of ggplot2 for Python.
youtu.be/xK9UNcOfjnI
youtu.be/xK9UNcOfjnI
[2025-07-18] Plots in Python with seaborn and plotnine
YouTube video by Leonardo Collado Torres
youtu.be
November 13, 2025 at 3:02 PM
Hot take: ggplot2 is better than any plotting option available in Python-- but I discuss a couple options in Python at an R Stats Club session @libdrstats.bsky.social linked below. I personally use plotnine, since it's essentially a port of ggplot2 for Python.
youtu.be/xK9UNcOfjnI
youtu.be/xK9UNcOfjnI
Reposted by Lieber Institute for Brain Development
I just completed my first radio 📻 interview ^_^
You'll be able to listen to it next Friday or so at www.iheart.com/podcast/269-.... Thanks Clau from iHeartRadio Miami's "Estamos Contigo" podcast for reaching out!
I'll be talking in Spanish about our recent #HabenulaLIBD 📜
bsky.app/profile/lcol...
You'll be able to listen to it next Friday or so at www.iheart.com/podcast/269-.... Thanks Clau from iHeartRadio Miami's "Estamos Contigo" podcast for reaching out!
I'll be talking in Spanish about our recent #HabenulaLIBD 📜
bsky.app/profile/lcol...
November 7, 2025 at 3:58 PM
I just completed my first radio 📻 interview ^_^
You'll be able to listen to it next Friday or so at www.iheart.com/podcast/269-.... Thanks Clau from iHeartRadio Miami's "Estamos Contigo" podcast for reaching out!
I'll be talking in Spanish about our recent #HabenulaLIBD 📜
bsky.app/profile/lcol...
You'll be able to listen to it next Friday or so at www.iheart.com/podcast/269-.... Thanks Clau from iHeartRadio Miami's "Estamos Contigo" podcast for reaching out!
I'll be talking in Spanish about our recent #HabenulaLIBD 📜
bsky.app/profile/lcol...
Reposted by Lieber Institute for Brain Development
Happy to share that our paper characterizing PrL dynamics during sustained attention is finally out. This work was a collaboration between the @martinowk.bsky.social and Greg Carr groups at @lieberinstitute.bsky.social . www.nature.com/articles/s41...
#Calicumimaging #miniscopes #rCPT #PrL
#Calicumimaging #miniscopes #rCPT #PrL
Patterns of neural activity in prelimbic cortex neurons correlate with attentional behavior in the rodent continuous performance test - Translational Psychiatry
Translational Psychiatry - Patterns of neural activity in prelimbic cortex neurons correlate with attentional behavior in the rodent continuous performance test
www.nature.com
November 7, 2025 at 6:42 PM
Happy to share that our paper characterizing PrL dynamics during sustained attention is finally out. This work was a collaboration between the @martinowk.bsky.social and Greg Carr groups at @lieberinstitute.bsky.social . www.nature.com/articles/s41...
#Calicumimaging #miniscopes #rCPT #PrL
#Calicumimaging #miniscopes #rCPT #PrL
Reposted by Lieber Institute for Brain Development
Had the most rewarding time at the HTNA #cshlcourses It was fun science-ing all day/night for 2wks to learn modern viral, whole 🧠 imaging & barcode-based seq approaches to understand neuroanatomy/function. Inspired & energized as I think of all the ways these tools can be applied in my own work!🧪 1/
November 6, 2025 at 11:55 PM
Had the most rewarding time at the HTNA #cshlcourses It was fun science-ing all day/night for 2wks to learn modern viral, whole 🧠 imaging & barcode-based seq approaches to understand neuroanatomy/function. Inspired & energized as I think of all the ways these tools can be applied in my own work!🧪 1/
Reposted by Lieber Institute for Brain Development
This study is part of an ongoing collaboration between mine and Greg Carr's group @lieberinstitute.bsky.social to develop translational screening platforms for identifying and validating interventions for deficits in sustained attention, a process disrupted across many neuropsychiatric disorders.
November 7, 2025 at 1:25 PM
This study is part of an ongoing collaboration between mine and Greg Carr's group @lieberinstitute.bsky.social to develop translational screening platforms for identifying and validating interventions for deficits in sustained attention, a process disrupted across many neuropsychiatric disorders.
Reposted by Lieber Institute for Brain Development
Our paper using endoscopic in vivo calcium imaging to uncover how neuronal population dynamics in the prelimbic cortex track attention and task engagement during the rodent continuous performance test (rCPT) is now online
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Patterns of neural activity in prelimbic cortex neurons correlate with attentional behavior in the rodent continuous performance test - Translational Psychiatry
Translational Psychiatry - Patterns of neural activity in prelimbic cortex neurons correlate with attentional behavior in the rodent continuous performance test
www.nature.com
November 7, 2025 at 1:25 PM
Our paper using endoscopic in vivo calcium imaging to uncover how neuronal population dynamics in the prelimbic cortex track attention and task engagement during the rodent continuous performance test (rCPT) is now online
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Lieber Institute for Brain Development
Para más, checa los anuncios de @lieberinstitute.bsky.social
🔗 www.libd.org/tiny-brain-r...
🔗 www.libd.org/inside-the-h...
además del comunicado de prensa de la Asociación Americana de Psiquiatría
🔗 www.psychiatry.org/News-room/Ne...
¡Y gracias a @lahuuki.bsky.social por el hilo 🧵 original!
🔗 www.libd.org/tiny-brain-r...
🔗 www.libd.org/inside-the-h...
además del comunicado de prensa de la Asociación Americana de Psiquiatría
🔗 www.psychiatry.org/News-room/Ne...
¡Y gracias a @lahuuki.bsky.social por el hilo 🧵 original!
Tiny Brain Region May Hold Clues to Schizophrenia, Scientists Say | The Lieber Institute for Brain Development | Research & Discovery
What the Study Found Scientists have long searched for what goes wrong in the brains of people with schizophrenia. Now, researchers at the Lieber Institute for Brain Development in Baltimore may have ...
www.libd.org
November 5, 2025 at 11:47 PM
Para más, checa los anuncios de @lieberinstitute.bsky.social
🔗 www.libd.org/tiny-brain-r...
🔗 www.libd.org/inside-the-h...
además del comunicado de prensa de la Asociación Americana de Psiquiatría
🔗 www.psychiatry.org/News-room/Ne...
¡Y gracias a @lahuuki.bsky.social por el hilo 🧵 original!
🔗 www.libd.org/tiny-brain-r...
🔗 www.libd.org/inside-the-h...
además del comunicado de prensa de la Asociación Americana de Psiquiatría
🔗 www.psychiatry.org/News-room/Ne...
¡Y gracias a @lahuuki.bsky.social por el hilo 🧵 original!
Reposted by Lieber Institute for Brain Development
Estos datos servirán para trabajo futuro sobre cambios moleculares que ocurren en #Habénula en enfermedades 🧠🧬 Mantén un 👀 abierto en @lieberinstitute.bsky.social para nuevos resultados de Hb de datos transcriptómicos con resolución espacial @10xgenomics.bsky.social
speakerdeck.com/lahuuki/2025...
speakerdeck.com/lahuuki/2025...
2025 LIBD lcolladotor data science team TL;DR
A recap of recent work from our R Bioconductor-powered Team Data Science group at the Lieber Institute for Data Science.
Team website: https://lcol…
speakerdeck.com
November 5, 2025 at 11:47 PM
Estos datos servirán para trabajo futuro sobre cambios moleculares que ocurren en #Habénula en enfermedades 🧠🧬 Mantén un 👀 abierto en @lieberinstitute.bsky.social para nuevos resultados de Hb de datos transcriptómicos con resolución espacial @10xgenomics.bsky.social
speakerdeck.com/lahuuki/2025...
speakerdeck.com/lahuuki/2025...
Reposted by Lieber Institute for Brain Development
Acá va en español 🇲🇽
--- o ---
"¡Estamos orgullosos de anunciar que nuestro artículo ‘Análisis Transcriptómico de la Habénula Humana en Esquizofrenia’ es el artículo de portada de la edición de noviembre del American Journal of Psychiatry!" 🧠 #HabenulaLIBD #snRNAseq #Habénula doi.org/10.1176/appi...
--- o ---
"¡Estamos orgullosos de anunciar que nuestro artículo ‘Análisis Transcriptómico de la Habénula Humana en Esquizofrenia’ es el artículo de portada de la edición de noviembre del American Journal of Psychiatry!" 🧠 #HabenulaLIBD #snRNAseq #Habénula doi.org/10.1176/appi...
November 5, 2025 at 11:47 PM
Acá va en español 🇲🇽
--- o ---
"¡Estamos orgullosos de anunciar que nuestro artículo ‘Análisis Transcriptómico de la Habénula Humana en Esquizofrenia’ es el artículo de portada de la edición de noviembre del American Journal of Psychiatry!" 🧠 #HabenulaLIBD #snRNAseq #Habénula doi.org/10.1176/appi...
--- o ---
"¡Estamos orgullosos de anunciar que nuestro artículo ‘Análisis Transcriptómico de la Habénula Humana en Esquizofrenia’ es el artículo de portada de la edición de noviembre del American Journal of Psychiatry!" 🧠 #HabenulaLIBD #snRNAseq #Habénula doi.org/10.1176/appi...
Reposted by Lieber Institute for Brain Development
Biostats professor @lcolladotor.bsky.social, along with his colleagues from @lieberinstitute.bsky.social, have created the first detailed molecular map of the human habenula, and with it gained new insights into its role in schizophrenia. Read the original study: psychiatryonline.org/doi/10.1176/...
Tiny Brain Region May Hold Clues to Schizophrenia, Scientists Say | The Lieber Institute for Brain Development | Research & Discovery
What the Study Found Scientists have long searched for what goes wrong in the brains of people with schizophrenia. Now, researchers at the Lieber Institute for Brain Development in Baltimore may have ...
www.libd.org
November 5, 2025 at 6:22 PM
Biostats professor @lcolladotor.bsky.social, along with his colleagues from @lieberinstitute.bsky.social, have created the first detailed molecular map of the human habenula, and with it gained new insights into its role in schizophrenia. Read the original study: psychiatryonline.org/doi/10.1176/...
Reposted by Lieber Institute for Brain Development
Excited to share that the second project from my time at @lieberinstitute.bsky.social with @lcolladotor.bsky.social is now published! This was such a rewarding collaboration to be part of. 💡🧠
Huge congrats to @lahuuki.bsky.social and all co-authors!
Huge congrats to @lahuuki.bsky.social and all co-authors!
Proud to announce our paper ‘Transcriptomic Analysis of the Human Habenula in Schizophrenia’ from @lieberinstitute.bsky.social is the cover article for the November issue of the American Journal of Psychiatry! 🧠 #HabenulaLIBD #snRNAseq #Habenula doi.org/10.1176/appi...
Transcriptomic Analysis of the Human Habenula in Schizophrenia | American Journal of Psychiatry
Objective: The objective of this study was to define the molecular neuroanatomy of the human habenula (Hb) and identify transcriptomic differences between brains of individuals with schizophrenia and ...
doi.org
November 5, 2025 at 4:58 PM
Excited to share that the second project from my time at @lieberinstitute.bsky.social with @lcolladotor.bsky.social is now published! This was such a rewarding collaboration to be part of. 💡🧠
Huge congrats to @lahuuki.bsky.social and all co-authors!
Huge congrats to @lahuuki.bsky.social and all co-authors!
Reposted by Lieber Institute for Brain Development
For more, check the @lieberinstitute.bsky.social announcements at
🔗 www.libd.org/tiny-brain-r...
🔗 www.libd.org/inside-the-h...
As well as the American Psychiatry Association press release
🔗 www.psychiatry.org/News-room/Ne...
🔗 www.libd.org/tiny-brain-r...
🔗 www.libd.org/inside-the-h...
As well as the American Psychiatry Association press release
🔗 www.psychiatry.org/News-room/Ne...
Inside the Habenula: Lieber Institute Researchers Uncover a Hidden Player in Schizophrenia
About the size of a pea, the habenula serves as a hub connecting key brain systems that regulate motivation, mood, and reward — all of which are disrupted in schizophrenia. Yet until now, the habenula...
www.libd.org
November 4, 2025 at 9:31 PM
For more, check the @lieberinstitute.bsky.social announcements at
🔗 www.libd.org/tiny-brain-r...
🔗 www.libd.org/inside-the-h...
As well as the American Psychiatry Association press release
🔗 www.psychiatry.org/News-room/Ne...
🔗 www.libd.org/tiny-brain-r...
🔗 www.libd.org/inside-the-h...
As well as the American Psychiatry Association press release
🔗 www.psychiatry.org/News-room/Ne...
Reposted by Lieber Institute for Brain Development
Thanks to @nataliematosin.bsky.social and Sophie Debs for highlighting our work in their editorial “Unlocking the Molecular Secrets of the Human Habenula”
🔗 doi.org/10.1176/appi...
🔗 doi.org/10.1176/appi...
Unlocking the Molecular Secrets of the Human Habenula | American Journal of Psychiatry
PsychiatryOnline.org is the platform for all American Psychiatric Association Publishing journals, DSM, and bestselling textbooks, as well as APA Practice Guidelines, and continuing medical education.
doi.org
November 4, 2025 at 9:31 PM
Thanks to @nataliematosin.bsky.social and Sophie Debs for highlighting our work in their editorial “Unlocking the Molecular Secrets of the Human Habenula”
🔗 doi.org/10.1176/appi...
🔗 doi.org/10.1176/appi...
Reposted by Lieber Institute for Brain Development
This data provides a foundation for future work into molecular changes that occur in the #Habenula in disease 🧠🧬 Keep an eye on @lieberinstitute.bsky.social for future work on the Hb spatially resolved transcriptomics with @10xgenomics.bsky.social tech #Visium and #Xenium 👀 #HabenulaLIBD
November 4, 2025 at 9:31 PM
This data provides a foundation for future work into molecular changes that occur in the #Habenula in disease 🧠🧬 Keep an eye on @lieberinstitute.bsky.social for future work on the Hb spatially resolved transcriptomics with @10xgenomics.bsky.social tech #Visium and #Xenium 👀 #HabenulaLIBD
Reposted by Lieber Institute for Brain Development
Thank you to all of our collaborators at the @lieberinstitute.bsky.social for their dedication and hard work on this project! 🧑🔬 #HabenulaLIBD @freneegf.bsky.social @nick-eagles.bsky.social @lcolladotor.bsky.social @kr-maynard.bsky.social @martinowk.bsky.social
November 4, 2025 at 9:31 PM
Thank you to all of our collaborators at the @lieberinstitute.bsky.social for their dedication and hard work on this project! 🧑🔬 #HabenulaLIBD @freneegf.bsky.social @nick-eagles.bsky.social @lcolladotor.bsky.social @kr-maynard.bsky.social @martinowk.bsky.social
Reposted by Lieber Institute for Brain Development
#OpenData and #OpenCode from our latest @lieberinstitute.bsky.social project
Lots of #RStats and @bioconductor.bsky.social code inside of that repository!
#OpenScience
Lots of #RStats and @bioconductor.bsky.social code inside of that repository!
#OpenScience
Our #Habenula #singlecell and differential expression data is available to explore via our interactive websites 💻 #opendata github.com/LieberInstit...
GitHub - LieberInstitute/Habenula_Pilot: habenulaPilot project code repository
habenulaPilot project code repository. Contribute to LieberInstitute/Habenula_Pilot development by creating an account on GitHub.
github.com
November 4, 2025 at 10:02 PM
#OpenData and #OpenCode from our latest @lieberinstitute.bsky.social project
Lots of #RStats and @bioconductor.bsky.social code inside of that repository!
#OpenScience
Lots of #RStats and @bioconductor.bsky.social code inside of that repository!
#OpenScience
Reposted by Lieber Institute for Brain Development
Congrats to @lahuuki.bsky.social and many members of @kr-maynard.bsky.social and @lcolladotor.bsky.social teams in our division who contributed to this study! Really excited to see this paper now published with contribution of data resources for molecular profiles of human habenula cell types 🧠🔬🧪
Proud to announce our paper ‘Transcriptomic Analysis of the Human Habenula in Schizophrenia’ from @lieberinstitute.bsky.social is the cover article for the November issue of the American Journal of Psychiatry! 🧠 #HabenulaLIBD #snRNAseq #Habenula doi.org/10.1176/appi...
Transcriptomic Analysis of the Human Habenula in Schizophrenia | American Journal of Psychiatry
Objective: The objective of this study was to define the molecular neuroanatomy of the human habenula (Hb) and identify transcriptomic differences between brains of individuals with schizophrenia and ...
doi.org
November 4, 2025 at 9:58 PM
Congrats to @lahuuki.bsky.social and many members of @kr-maynard.bsky.social and @lcolladotor.bsky.social teams in our division who contributed to this study! Really excited to see this paper now published with contribution of data resources for molecular profiles of human habenula cell types 🧠🔬🧪
Reposted by Lieber Institute for Brain Development
Proud to announce our paper ‘Transcriptomic Analysis of the Human Habenula in Schizophrenia’ from @lieberinstitute.bsky.social is the cover article for the November issue of the American Journal of Psychiatry! 🧠 #HabenulaLIBD #snRNAseq #Habenula doi.org/10.1176/appi...
Transcriptomic Analysis of the Human Habenula in Schizophrenia | American Journal of Psychiatry
Objective: The objective of this study was to define the molecular neuroanatomy of the human habenula (Hb) and identify transcriptomic differences between brains of individuals with schizophrenia and ...
doi.org
November 4, 2025 at 9:31 PM
Proud to announce our paper ‘Transcriptomic Analysis of the Human Habenula in Schizophrenia’ from @lieberinstitute.bsky.social is the cover article for the November issue of the American Journal of Psychiatry! 🧠 #HabenulaLIBD #snRNAseq #Habenula doi.org/10.1176/appi...
Reposted by Lieber Institute for Brain Development
We recently checked out tidySingleCellExperiment at the R Stats Club @libdrstats.bsky.social, an R package part of a broader effort to bring tidy coding to genomics. Pretty useful!
youtu.be/ob_SQY4-YjQ?...
#RStats
youtu.be/ob_SQY4-YjQ?...
#RStats
[2025-07-11] Tidy manipulation of SingleCellExperiment objects
YouTube video by Leonardo Collado Torres
youtu.be
November 4, 2025 at 4:09 PM
We recently checked out tidySingleCellExperiment at the R Stats Club @libdrstats.bsky.social, an R package part of a broader effort to bring tidy coding to genomics. Pretty useful!
youtu.be/ob_SQY4-YjQ?...
#RStats
youtu.be/ob_SQY4-YjQ?...
#RStats
Reposted by Lieber Institute for Brain Development
Huge effort across many teams at @lieberinstitute.bsky.social. Shout out to @kr-maynard.bsky.social and Stephanie Page for major contributions to supervision and project management and computational collaboration with @stephaniehicks.bsky.social at @jhubiostat.bsky.social
October 31, 2025 at 5:24 PM
Huge effort across many teams at @lieberinstitute.bsky.social. Shout out to @kr-maynard.bsky.social and Stephanie Page for major contributions to supervision and project management and computational collaboration with @stephaniehicks.bsky.social at @jhubiostat.bsky.social
Reposted by Lieber Institute for Brain Development
Excited to share our newest project using spatial transcriptomics with novel image analysis approaches to investigate the impact of biological risk factors for Alzheimer's disease (AD) - APOE haplotype, sex, and genomic ancestry - on molecular states in the locus coeruleus (LC 🔵) of the human 🧠.
Got with the times + made a BSky to share our new, large-scale spatial RNAseq study of adult human #locuscoeruleus! Co-1st auth and cryostat wizard @heenadivecha.bsky.social squeezed 85 tissue sections into 43 Visium arrays. (1/8)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Impact of Alzheimer's disease risk factors and local neuromelanin content on the transcriptomic landscape of the human locus coeruleus
The locus coeruleus (LC) is a small noradrenergic nucleus in the dorsal pons that sends projections across the brain regulating sleep, arousal, attention, stress responses, and some forms of cognition...
www.biorxiv.org
October 31, 2025 at 5:24 PM
Excited to share our newest project using spatial transcriptomics with novel image analysis approaches to investigate the impact of biological risk factors for Alzheimer's disease (AD) - APOE haplotype, sex, and genomic ancestry - on molecular states in the locus coeruleus (LC 🔵) of the human 🧠.
Reposted by Lieber Institute for Brain Development
Got with the times + made a BSky to share our new, large-scale spatial RNAseq study of adult human #locuscoeruleus! Co-1st auth and cryostat wizard @heenadivecha.bsky.social squeezed 85 tissue sections into 43 Visium arrays. (1/8)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Impact of Alzheimer's disease risk factors and local neuromelanin content on the transcriptomic landscape of the human locus coeruleus
The locus coeruleus (LC) is a small noradrenergic nucleus in the dorsal pons that sends projections across the brain regulating sleep, arousal, attention, stress responses, and some forms of cognition...
www.biorxiv.org
October 31, 2025 at 3:42 PM
Got with the times + made a BSky to share our new, large-scale spatial RNAseq study of adult human #locuscoeruleus! Co-1st auth and cryostat wizard @heenadivecha.bsky.social squeezed 85 tissue sections into 43 Visium arrays. (1/8)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...