Adrien Lemaignen
@lemaignen.bsky.social
ID doc - specific interest in epidemiology, bone and joint infections, bloodstream infections and endocarditis, zoonoses
Tours, France
Tours, France
Reposted by Adrien Lemaignen
Diagnostic Efficacy and Clinical Impact of Image-guided Core Needle Biopsy of Suspected Adult Non-Vertebral Osteomyelitis
✅ Just Accepted
🔗 https://bit.ly/4oYHCGS
✅ Just Accepted
🔗 https://bit.ly/4oYHCGS
November 5, 2025 at 7:40 PM
Diagnostic Efficacy and Clinical Impact of Image-guided Core Needle Biopsy of Suspected Adult Non-Vertebral Osteomyelitis
✅ Just Accepted
🔗 https://bit.ly/4oYHCGS
✅ Just Accepted
🔗 https://bit.ly/4oYHCGS
Reposted by Adrien Lemaignen
🆕🌟Excellent review article
P2Y12 inhibitors(eg clopidogrel,ticagrelor)in Staphylococcus aureus bacteraemia: current evidence and clinical implications
Coming soon: CLOPI-SNAP+ Clopido-SNAP #idsky #EMIMCC
www.thelancet.com/journals/lan...
P2Y12 inhibitors(eg clopidogrel,ticagrelor)in Staphylococcus aureus bacteraemia: current evidence and clinical implications
Coming soon: CLOPI-SNAP+ Clopido-SNAP #idsky #EMIMCC
www.thelancet.com/journals/lan...
P2Y12 inhibitors in Staphylococcus aureus bacteraemia: current evidence and clinical implications
Staphylococcus aureus bacteraemia presents a substantial clinical burden, with high
rates of morbidity and mortality. Despite its severity, therapeutic advancements have
been small in the past decade,...
www.thelancet.com
October 31, 2025 at 8:18 PM
🆕🌟Excellent review article
P2Y12 inhibitors(eg clopidogrel,ticagrelor)in Staphylococcus aureus bacteraemia: current evidence and clinical implications
Coming soon: CLOPI-SNAP+ Clopido-SNAP #idsky #EMIMCC
www.thelancet.com/journals/lan...
P2Y12 inhibitors(eg clopidogrel,ticagrelor)in Staphylococcus aureus bacteraemia: current evidence and clinical implications
Coming soon: CLOPI-SNAP+ Clopido-SNAP #idsky #EMIMCC
www.thelancet.com/journals/lan...
Reposted by Adrien Lemaignen
Effectiveness of Nebulized Bronchodilator - Enhanced Sputum Induction in Thai Patients with Presumed Pulmonary Tuberculosis; A Randomized Controlled Trial; (NeB-TB Trial)
✅ Just Accepted
#IDSky
✅ Just Accepted
#IDSky
Effectiveness of Nebulized Bronchodilator - Enhanced Sputum Induction in Thai Patients with Presumed Pulmonary Tuberculosis; A Randomized Controlled Trial; (NeB-TB Trial)
AbstractBackground. Delayed pulmonary tuberculosis (TB) diagnosis, especially with limited bronchoscopy resources, worsens outcomes and increases transmiss
bit.ly
October 28, 2025 at 3:51 PM
Effectiveness of Nebulized Bronchodilator - Enhanced Sputum Induction in Thai Patients with Presumed Pulmonary Tuberculosis; A Randomized Controlled Trial; (NeB-TB Trial)
✅ Just Accepted
#IDSky
✅ Just Accepted
#IDSky
Reposted by Adrien Lemaignen
[Publication] The article "Risk factors for deep vein thrombosis during peripherally inserted central catheter-related infections: A retrospective study" is now available.
www.sciencedirect.com/science/arti...
#IDsky #PeripherallyInsertedCentralCatheter #DeepVeinThrombosis #RiskFactors #S.Aureus
www.sciencedirect.com/science/arti...
#IDsky #PeripherallyInsertedCentralCatheter #DeepVeinThrombosis #RiskFactors #S.Aureus
Risk factors for deep vein thrombosis during peripherally inserted central catheter-related infections: A retrospective study
Peripherally inserted central catheters (PICCs) are associated with complications including deep vein thrombosis (DVT) and infections. However, the ri…
www.sciencedirect.com
October 27, 2025 at 7:12 AM
[Publication] The article "Risk factors for deep vein thrombosis during peripherally inserted central catheter-related infections: A retrospective study" is now available.
www.sciencedirect.com/science/arti...
#IDsky #PeripherallyInsertedCentralCatheter #DeepVeinThrombosis #RiskFactors #S.Aureus
www.sciencedirect.com/science/arti...
#IDsky #PeripherallyInsertedCentralCatheter #DeepVeinThrombosis #RiskFactors #S.Aureus
Reposted by Adrien Lemaignen
DNA from Napoleon’s 1812 army identifies the pathogens likely responsible for the army’s demise during their Russian retreat. www.cell.com/current-biol...
Nicolás Rascovan & colleagues
@currentbiology.bsky.social
Nicolás Rascovan & colleagues
@currentbiology.bsky.social
October 24, 2025 at 3:00 PM
DNA from Napoleon’s 1812 army identifies the pathogens likely responsible for the army’s demise during their Russian retreat. www.cell.com/current-biol...
Nicolás Rascovan & colleagues
@currentbiology.bsky.social
Nicolás Rascovan & colleagues
@currentbiology.bsky.social
Reposted by Adrien Lemaignen
Reposted by Adrien Lemaignen
This monocentric observational study of 137 patients with bone & joint infection treated by clindamycin of which 88 received monotherapy shows in univariate, multivariate & IPTW analysis a reliable & safe use of monotherapy in those infections:
doi.org/10.1093/jaca...
#JACAMRNews #IDSky
doi.org/10.1093/jaca...
#JACAMRNews #IDSky
doi.org
October 23, 2025 at 10:03 AM
This monocentric observational study of 137 patients with bone & joint infection treated by clindamycin of which 88 received monotherapy shows in univariate, multivariate & IPTW analysis a reliable & safe use of monotherapy in those infections:
doi.org/10.1093/jaca...
#JACAMRNews #IDSky
doi.org/10.1093/jaca...
#JACAMRNews #IDSky
Reposted by Adrien Lemaignen
🆕🔥🔥CloCeBa RCT
Cloxacillin versus cefazolin for MSSA Bacteraemia
Cefazolin has a non-inferior efficacy regarding mortality, microbiological or clinical endpoints and was associated with a lower rate of serious adverse events #IDSky
www.thelancet.com/journals/lan...
Cloxacillin versus cefazolin for MSSA Bacteraemia
Cefazolin has a non-inferior efficacy regarding mortality, microbiological or clinical endpoints and was associated with a lower rate of serious adverse events #IDSky
www.thelancet.com/journals/lan...
October 19, 2025 at 4:34 AM
🆕🔥🔥CloCeBa RCT
Cloxacillin versus cefazolin for MSSA Bacteraemia
Cefazolin has a non-inferior efficacy regarding mortality, microbiological or clinical endpoints and was associated with a lower rate of serious adverse events #IDSky
www.thelancet.com/journals/lan...
Cloxacillin versus cefazolin for MSSA Bacteraemia
Cefazolin has a non-inferior efficacy regarding mortality, microbiological or clinical endpoints and was associated with a lower rate of serious adverse events #IDSky
www.thelancet.com/journals/lan...
Reposted by Adrien Lemaignen
New review article
Role of gut #microbiota disruption in prosthetic joint infection: a scoping review
www.thelancet.com/journals/lan...
#IDSky #ClinMicro #PJI #OpenAccess #OA
Role of gut #microbiota disruption in prosthetic joint infection: a scoping review
www.thelancet.com/journals/lan...
#IDSky #ClinMicro #PJI #OpenAccess #OA
September 8, 2025 at 2:09 PM
New review article
Role of gut #microbiota disruption in prosthetic joint infection: a scoping review
www.thelancet.com/journals/lan...
#IDSky #ClinMicro #PJI #OpenAccess #OA
Role of gut #microbiota disruption in prosthetic joint infection: a scoping review
www.thelancet.com/journals/lan...
#IDSky #ClinMicro #PJI #OpenAccess #OA
Reposted by Adrien Lemaignen
🆕🔥State of art review with many🌟s
+ Prof. Jason Roberts
Antibiotic therapy for severe bacterial infections
🟢When to start and not to start antibiotics?
🟢Mon vs combo Abx
🟢PK/PD principles
🟢Drug–drug inx
A #mustread article for ID professional #idsky
link.springer.com/article/10.1...
+ Prof. Jason Roberts
Antibiotic therapy for severe bacterial infections
🟢When to start and not to start antibiotics?
🟢Mon vs combo Abx
🟢PK/PD principles
🟢Drug–drug inx
A #mustread article for ID professional #idsky
link.springer.com/article/10.1...
September 2, 2025 at 2:03 PM
🆕🔥State of art review with many🌟s
+ Prof. Jason Roberts
Antibiotic therapy for severe bacterial infections
🟢When to start and not to start antibiotics?
🟢Mon vs combo Abx
🟢PK/PD principles
🟢Drug–drug inx
A #mustread article for ID professional #idsky
link.springer.com/article/10.1...
+ Prof. Jason Roberts
Antibiotic therapy for severe bacterial infections
🟢When to start and not to start antibiotics?
🟢Mon vs combo Abx
🟢PK/PD principles
🟢Drug–drug inx
A #mustread article for ID professional #idsky
link.springer.com/article/10.1...
Reposted by Adrien Lemaignen
Rapid diagnostic tests combined with individualised decision-making improve the selection of antibiotic therapy. Rapid de-escalation to narrow-spectrum monotherapy and shortening of the duration of therapy should be the rule. #IDsky #EMIMCC
🆕🔥State of art review with many🌟s
+ Prof. Jason Roberts
Antibiotic therapy for severe bacterial infections
🟢When to start and not to start antibiotics?
🟢Mon vs combo Abx
🟢PK/PD principles
🟢Drug–drug inx
A #mustread article for ID professional #idsky
link.springer.com/article/10.1...
+ Prof. Jason Roberts
Antibiotic therapy for severe bacterial infections
🟢When to start and not to start antibiotics?
🟢Mon vs combo Abx
🟢PK/PD principles
🟢Drug–drug inx
A #mustread article for ID professional #idsky
link.springer.com/article/10.1...
September 2, 2025 at 8:26 PM
Reposted by Adrien Lemaignen
In CID, Maria Ines Figueroa and colleagues evaluated the antiviral activity of dolutegravir/lamivudine among antiretroviral therapy (ART)-naive patients with HIV with a CD4 count ≤200 cells/mm³. https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaf415/8241230
Efficacy and Safety of Dual Therapy With Dolutegravir/Lamivudine in Treatment-naive Persons With CD4 Counts <200/mm3: 48-Week Results of the DOLCE Study
Treatment-naive people with human immunodeficiency virus with very low CD4 counts and high viral load are a difficult-to-treat population. DOLCE explored t
academic.oup.com
September 3, 2025 at 2:20 AM
In CID, Maria Ines Figueroa and colleagues evaluated the antiviral activity of dolutegravir/lamivudine among antiretroviral therapy (ART)-naive patients with HIV with a CD4 count ≤200 cells/mm³. https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaf415/8241230
Reposted by Adrien Lemaignen
This retrospective cohort from 🇫🇷showed that oral switch is a suitable option for treating IE, even for POET-ineligible patients
➡️treatment failure HR=0.55 favoring oral, 95%CI 0.27-1.17
➡️more days alive outside 🏥 in oral group (59 vs 47, p=0.001)
doi.org/10.1093/cid/...
#IDSky
➡️treatment failure HR=0.55 favoring oral, 95%CI 0.27-1.17
➡️more days alive outside 🏥 in oral group (59 vs 47, p=0.001)
doi.org/10.1093/cid/...
#IDSky
August 18, 2025 at 2:48 PM
This retrospective cohort from 🇫🇷showed that oral switch is a suitable option for treating IE, even for POET-ineligible patients
➡️treatment failure HR=0.55 favoring oral, 95%CI 0.27-1.17
➡️more days alive outside 🏥 in oral group (59 vs 47, p=0.001)
doi.org/10.1093/cid/...
#IDSky
➡️treatment failure HR=0.55 favoring oral, 95%CI 0.27-1.17
➡️more days alive outside 🏥 in oral group (59 vs 47, p=0.001)
doi.org/10.1093/cid/...
#IDSky
Reposted by Adrien Lemaignen
[Publication] The article "West Nile virus in Italy: A rising public health concern calling for reinforced surveillance and preventive measures" is now available.
www.sciencedirect.com/science/arti...
#IDsky #WestNileVirus #PublicHealthSurveillance #VectorBorneDiseases #OneHealthApproachItaly
www.sciencedirect.com/science/arti...
#IDsky #WestNileVirus #PublicHealthSurveillance #VectorBorneDiseases #OneHealthApproachItaly
West Nile virus in Italy: A rising public health concern calling for reinforced surveillance and preventive measures
www.sciencedirect.com
August 8, 2025 at 7:56 AM
[Publication] The article "West Nile virus in Italy: A rising public health concern calling for reinforced surveillance and preventive measures" is now available.
www.sciencedirect.com/science/arti...
#IDsky #WestNileVirus #PublicHealthSurveillance #VectorBorneDiseases #OneHealthApproachItaly
www.sciencedirect.com/science/arti...
#IDsky #WestNileVirus #PublicHealthSurveillance #VectorBorneDiseases #OneHealthApproachItaly
Reposted by Adrien Lemaignen
The Use of Oritavancin as Consolidation Therapy for Infective Endocarditis Caused by Enterococcus spp.
✅ Just Accepted
#IDSky
✅ Just Accepted
#IDSky
The Use of Oritavancin as Consolidation Therapy for Infective Endocarditis Caused by Enterococcus spp.
Oritavancin is emerging as a potential alternative to standard antibiotic regimens in the treatment of infective endocarditis caused by gram-positive bacteria, though evidence remains limited.
doi.org
August 5, 2025 at 2:49 PM
The Use of Oritavancin as Consolidation Therapy for Infective Endocarditis Caused by Enterococcus spp.
✅ Just Accepted
#IDSky
✅ Just Accepted
#IDSky
Reposted by Adrien Lemaignen
State-of-the-Art Review: Anal Cancer Screening in People With HIV
#IDSky
academic.oup.com/cid/article/...
#IDSky
academic.oup.com/cid/article/...
State-of-the-Art Review: Anal Cancer Screening in People With HIV
New data and clinical guidelines support anal cancer screening of people with HIV, but important questions related to overall effectiveness, harms, and equitable deployment must be considered when implementing them.
academic.oup.com
August 4, 2025 at 6:58 PM
State-of-the-Art Review: Anal Cancer Screening in People With HIV
#IDSky
academic.oup.com/cid/article/...
#IDSky
academic.oup.com/cid/article/...
Reposted by Adrien Lemaignen
Adjunctive Fosfomycin for the Treatment of Staphylococcus aureus Bacteremia: A Pooled Post-hoc Analysis of Individual Participant Data from Two Randomized Trials
✅ Just Accepted
#IDSky
✅ Just Accepted
#IDSky
Adjunctive Fosfomycin for the Treatment of Staphylococcus aureus Bacteremia: A Pooled Post-hoc Analysis of Individual Participant Data from Two Randomized Trials
The role of adjunctive fosfomycin in Staphylococcus aureus bacteremia (SAB) remains uncertain.
doi.org
July 17, 2025 at 6:58 PM
Adjunctive Fosfomycin for the Treatment of Staphylococcus aureus Bacteremia: A Pooled Post-hoc Analysis of Individual Participant Data from Two Randomized Trials
✅ Just Accepted
#IDSky
✅ Just Accepted
#IDSky
Reposted by Adrien Lemaignen
Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid: First Year Experience at a Tertiary Referral Hospital
✅ Just Accepted
#IDSky
✅ Just Accepted
#IDSky
Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid: First Year Experience at a Tertiary Referral Hospital
Central nervous system (CNS) infections are significant causes of morbidity and mortality, especially when diagnosis is delayed.
doi.org
July 18, 2025 at 12:41 PM
Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid: First Year Experience at a Tertiary Referral Hospital
✅ Just Accepted
#IDSky
✅ Just Accepted
#IDSky
Reposted by Adrien Lemaignen
SNAP trial update
➡️ The DSMC provided a recommendation to close the ADJUNCTIVE domain (Clindamycin), due to a statistical trigger for futility being met.
#IDsky
➡️ The DSMC provided a recommendation to close the ADJUNCTIVE domain (Clindamycin), due to a statistical trigger for futility being met.
#IDsky
July 16, 2025 at 11:07 AM
SNAP trial update
➡️ The DSMC provided a recommendation to close the ADJUNCTIVE domain (Clindamycin), due to a statistical trigger for futility being met.
#IDsky
➡️ The DSMC provided a recommendation to close the ADJUNCTIVE domain (Clindamycin), due to a statistical trigger for futility being met.
#IDsky
Reposted by Adrien Lemaignen
2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Histoplasmosis: Treatment of Asymptomatic Histoplasma Pulmonary Nodules (Histoplasmomas) in Adults, Children, and Pregnant People
@jobadd.bsky.social @joshuawolf.bsky.social et al
doi.org/10.1093/cid/...
@jobadd.bsky.social @joshuawolf.bsky.social et al
doi.org/10.1093/cid/...
July 8, 2025 at 2:34 PM
2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Histoplasmosis: Treatment of Asymptomatic Histoplasma Pulmonary Nodules (Histoplasmomas) in Adults, Children, and Pregnant People
@jobadd.bsky.social @joshuawolf.bsky.social et al
doi.org/10.1093/cid/...
@jobadd.bsky.social @joshuawolf.bsky.social et al
doi.org/10.1093/cid/...
Reposted by Adrien Lemaignen
Association Between Delayed Broad-Spectrum Gram-negative Antibiotics and Clinical Outcomes: How Much Does Getting It Right With Empiric Antibiotics Matter?
Association Between Delayed Broad-Spectrum Gram-negative Antibiotics and Clinical Outcomes: How Much Does Getting It Right With Empiric Antibiotics Matter?
academic.oup.com
July 7, 2025 at 6:59 PM
Association Between Delayed Broad-Spectrum Gram-negative Antibiotics and Clinical Outcomes: How Much Does Getting It Right With Empiric Antibiotics Matter?
Reposted by Adrien Lemaignen
July 2025 Issue is now online: www.clinicalmicrobiologyandinfection.com/issue/S1198-...
July 1, 2025 at 4:46 PM
July 2025 Issue is now online: www.clinicalmicrobiologyandinfection.com/issue/S1198-...
Reposted by Adrien Lemaignen
What is the impact of anti-enterococcal empirical therapy on survival of patients with enterococcal bloodstream infections?
✅ Just Accepted
⭐ Editor's Choice
#IDSky
✅ Just Accepted
⭐ Editor's Choice
#IDSky
What is the impact of anti-enterococcal empirical therapy on survival of patients with enterococcal bloodstream infections?
The impact of early administration of active anti-enterococcal empirical therapy (EET) on outcomes of patients with enterococcal bloodstream infections (EBSI) is unclear.
academic.oup.com
July 1, 2025 at 6:58 PM
What is the impact of anti-enterococcal empirical therapy on survival of patients with enterococcal bloodstream infections?
✅ Just Accepted
⭐ Editor's Choice
#IDSky
✅ Just Accepted
⭐ Editor's Choice
#IDSky
Reposted by Adrien Lemaignen
📢 New @ecdc.europa.eu guidelines: "Public health guidance for assessing and mitigating the risk of locally-acquired #Aedes-borne #viral diseases (eg. #dengue, #chikungunya #WestNile virus and #Zika) in the #EU 🇪🇺/EEA"
🦟 #arbovirus
www.ecdc.europa.eu/en/publicati...
🦟 #arbovirus
www.ecdc.europa.eu/en/publicati...
July 2, 2025 at 12:19 PM
📢 New @ecdc.europa.eu guidelines: "Public health guidance for assessing and mitigating the risk of locally-acquired #Aedes-borne #viral diseases (eg. #dengue, #chikungunya #WestNile virus and #Zika) in the #EU 🇪🇺/EEA"
🦟 #arbovirus
www.ecdc.europa.eu/en/publicati...
🦟 #arbovirus
www.ecdc.europa.eu/en/publicati...
Reposted by Adrien Lemaignen
[Publication] L'article "Réforme du 3e cycle et DES de Maladies Infectieuses et Tropicales : quel bilan? Une enquête transversale nationale" est disponible dès aujourd'hui.
www.sciencedirect.com/science/arti...
#IDskyFR #MaladiesInfectieuses #FormationMédicale #DocteurJunior #QualitéDeVie
www.sciencedirect.com/science/arti...
#IDskyFR #MaladiesInfectieuses #FormationMédicale #DocteurJunior #QualitéDeVie
Réforme du 3e cycle et DES de Maladies Infectieuses et Tropicales : quel bilan? Une enquête transversale nationale.
La réforme du 3e cycle des études médicales effective depuis 2017 a permis la création d’un nouveau diplôme d’études spécialisées (DES) en Maladies In…
www.sciencedirect.com
June 30, 2025 at 7:16 AM
[Publication] L'article "Réforme du 3e cycle et DES de Maladies Infectieuses et Tropicales : quel bilan? Une enquête transversale nationale" est disponible dès aujourd'hui.
www.sciencedirect.com/science/arti...
#IDskyFR #MaladiesInfectieuses #FormationMédicale #DocteurJunior #QualitéDeVie
www.sciencedirect.com/science/arti...
#IDskyFR #MaladiesInfectieuses #FormationMédicale #DocteurJunior #QualitéDeVie