Léa Swistak
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leaswistak.bsky.social
Léa Swistak
@leaswistak.bsky.social
110 followers 110 following 3 posts
🇪🇺 | Cellular microbiology | Cryo-ET | EIPOD-LinC postdoctoral fellow Mahamid lab @EMBL | Before PhD in the Enninga lab @InstitutPasteur
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Reposted by Léa Swistak
lemonde.fr
LinkedIn va utiliser à partir de lundi les données personnelles de ses utilisateurs pour entraîner son IA
LinkedIn va utiliser à partir de lundi les données personnelles de ses utilisateurs pour entraîner son IA
La collecte des données des usagers commencera le 3 novembre, prévient le réseau social. Il leur est toutefois donné la possibilité de s’y opposer.
www.lemonde.fr
November 2, 2025 at 7:58 PM
Reposted by Léa Swistak
joedobbs.bsky.social
New paper from my colleague Soheil in the Mahamid and @jonasries.bsky.social groups looking at factors influencing laser devitrification on frozen #cryoem samples. With a far-red fluorophore, all-gold support grids will be especially good for correlative cryo-SMLM and EM!

doi.org/10.1016/j.js...
July 19, 2025 at 2:32 AM
Reposted by Léa Swistak
shigellameeting.bsky.social
Only 328 days to go! We're very busy behind the scenes getting thigns ready for the meeting! In the meantime you can add your email address for updates here: coming-soon.embo.org/w26-04
Shigella, the first international meeting
coming-soon.embo.org
May 27, 2025 at 3:22 PM
leaswistak.bsky.social
Diving “Google earth mode 🌍” in a Shigella infected cell 🔬🔎
Together with @m-albert.bsky.social
pasteur.fr Institut Pasteur | 130 years of biomedical research @pasteur.fr · May 26
Zoom into a human cell infected by Shigella, the bacteria behind dysentery. Using cryo-EM, @leaswistak.bsky.social and team revealed how it pierces cells with molecular syringes. Stunning science at the nanoscale.

@enningalab.bsky.social @jytinevez.bsky.social @nanoimaging.bsky.social

#CryoEM
May 26, 2025 at 9:46 AM
Reposted by Léa Swistak
plosbiology.org
How do intracellular #bacteria breach vacuoles to enter the host cytosol? @leaswistak.bsky.social @matthijnvos.bsky.social @enningalab.bsky.social &co show that #Shigella uses its T3SS system to damage endomembranes via mechanoporation to initiate cytosolic access @plosbiology.org 🧪 plos.io/4jXrr9Z
Left: Group of three T3SS localizing in the same zone of the bacteria surface. T3SS n°1 and 2 contact, deform, and perforate the vacuole membrane at the same spot. T3SS n°1 needle (83 nm) is long and seems to deviate from basal body axis showing that strong constraints between T3SS and the vacuole at are play. The locally relaxed vacuole to bacteria space (~50–55 nm) potentially limits additional damage by the T3SS n°3 needle (56 nm) that only slightly deforms the membrane. Right: Model of initial vacuolar membrane breaching by T3SS-induced mechanoporation. Shigella actively enters host cells in a specialized endomembrane compartment, the vacuole, that is rapidly injured and ruptured for cytosolic access. After host cell entry, the vacuole membrane is intact and tightly juxtaposed to the surface of Shigella, permitting contact between T3SSs and the endomembrane. In the authors’ proposed model, vacuole membrane injury is supported both by the vacuole tightness and the length of individual T3SSs.
May 2, 2025 at 5:00 PM
leaswistak.bsky.social
Great event! Super experience as a speaker/trainer. Looking forward for the next edition 😄
events.embl.org EMBL Events @events.embl.org · Feb 17
A big shoutout to all participants, trainers, speakers, and organizers for making last week's #EMBOCLEM such a success! 🙌

Your enthusiasm and curiosity made the course into a great experience for all involved. We hope the new skills and connections will inspire your future research 🥼
February 17, 2025 at 11:57 PM