Wish it was easier to calculate PGS in trusted research environments (TRE) like DNAnexus or the All of Us workbench? Us to! We've been hard at work on a new version of pgsc_calc to make it more scalable in those TREs! Introducing pgsc_calc v3.0.0-alpha.1: pgsc-calc.readthedocs.io/en/v3-alpha.1/

Stay tuned here for upcoming updates to pgsc_calc (github.com/PGScatalog/p...), our tool for reproducible PGS calculation. Our next version aims to increase the scalability to WGS data in cloud trusted research environments (e.g. All of Us).

Another month and lots of new & useful data added to www.PGSCatalog.org! Including new multi-ancestry insulin resistance scores, a score tailored for heart failure in East Asian individuals & more!

At #ISMB2025 in Liverpool? Interested in polygenic scores? Ben Wingfield will be back at his poster this afternoon at 4 PM (B507 / TransMed) to discuss all things pgsc_calc - our portable, scalable Nextflow workflow, designed for PGS calculation at scale in TREs! Go say hello!

Check out this PRS (www.pgscatalog.org/publication/...) and more in the latest PGS Catalog data release! Thanks to @pnatarajanmd.bsky.social & co for submitting their scores! See www.pgscatalog.org/submit for information about how to share your work!

We're working closely with our PredictDB colleagues to bring you an integrated resource for multi-omic predictors

We're happy to announce that PrediXcan GTExV8 expression predictors are now annotated and openly available via OmicsPred! www.omicspred.org

More info www.omicspred.org/publication/...

Interested in the results of the BARCODE PRS-guided prostate cancer screening study last month in @nejm.org? Just added to the Catalog is the PRS that was used in the cohort: www.pgscatalog.org/score/PGS005.... This and more in the latest release!

Thanks to @mglevin.bsky.social for sharing this new heart failure PRS from @naturegenet.bsky.social, 🔗: www.pgscatalog.org/score/PGS005.... This and more in the latest release, submit your scores at www.pgscatalog.org/submit!

Discover data from our latest release:
- New PGS for atrial fibrillation (buff.ly/E1TkmKv)
- PGS optimised for East Asian ancestry in cancer (buff.ly/gLkYKVo) and 10 other common diseases (buff.ly/nG7rOIq)

Find out how to submit your data here: buff.ly/nJCjUMr

Interested in calculating polygenic scores in the All Of Us workbench? Like those from @pgscatalog.bsky.social? Take a look at our new documentation for how to run pgsc_calc in the cloud environment: pgsc-calc.readthedocs.io/en/latest/ho.... Very much work-in-progress, optimisations incoming!

📣 Excited to share our new tutorial with @training.ebi.embl.org ! The course covers the basics of polygenic scores and describes the PGS Catalog resources (buff.ly/L8e6a3J, including pgsc_calc), a great overview of the area. Access the course online at buff.ly/CEBWMio!

Also out today is this multi-ancestry PGS for PSA! 🔗: www.pgscatalog.org/publication/...

Now available in the PGS Catalog 🔗: www.pgscatalog.org/publication/...! Thanks to authors like Sean for submitting the data directly, find out how to submit your data at pgscatalog.org/submit

OmicsPred is developed by @laurentgil33.bsky.social @yuxu.bsky.social @iamslambert.bsky.social @mikeinouye.bsky.social with support from @uniofcam.bsky.social, HDRUK, @ebi.embl.org and the Baker Institute. Many thanks also to @hakyim.bsky.social, Ruidong Xiang, many others! (8/N)