Laura Santini
@laurasantini.bsky.social
Stem cell Researcher in love with Developmental and Chromatin Biology
PostDoc at @mskcc in @tommyvierbuchen lab
Formerly PhD student at @viennabiocenter in @theleeboratory
PostDoc at @mskcc in @tommyvierbuchen lab
Formerly PhD student at @viennabiocenter in @theleeboratory
Start the weekend by checking out the latest paper from the Vierbuchen lab, spearheaded by amazing @danielmedinacano.bsky.social 🎉 Congrats to all authors!!
A mouse organoid platform for modeling cerebral cortex development and cis-regulatory evolution in vitro: Developmental Cell www.cell.com/developmenta...
August 29, 2025 at 5:42 PM
Start the weekend by checking out the latest paper from the Vierbuchen lab, spearheaded by amazing @danielmedinacano.bsky.social 🎉 Congrats to all authors!!
Reposted by Laura Santini
Excited to share our latest manuscript, a collaboration with @justinperryphd.bsky.social led by Weill Cornell Neuroscience PhD student @annbaako.bsky.social. Ann developed a new, improved mouse PSC model for studying tissue-resident macrophage differentiation.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Modeling tissue-resident macrophage development from mouse pluripotent stem cells
Tissue-resident macrophages (TRMs) are innate immune cells that participate in tissue development, homeostasis, and immune surveillance. Extensive efforts have been made to recapitulate TRM developmen...
www.biorxiv.org
May 13, 2025 at 7:37 PM
Excited to share our latest manuscript, a collaboration with @justinperryphd.bsky.social led by Weill Cornell Neuroscience PhD student @annbaako.bsky.social. Ann developed a new, improved mouse PSC model for studying tissue-resident macrophage differentiation.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
So glad this great story is finally out! Congrats to all authors!
By definition, enhancers can activate from a distance. But with increased distance between enhancer and promoter, the activation drops. To study this systematically, we build a synthetic locus: www.cell.com/molecular-ce... 1/12
Redirecting
doi.org
December 3, 2024 at 3:10 AM
So glad this great story is finally out! Congrats to all authors!
Reposted by Laura Santini
Happy to share our mouse cortical organoid system, which recapitulates in vivo tempos and cell types. We used it to identify gene expression changes across subspecies during development, which might underlie neuroanatomical differences and affect disease penetrance. www.biorxiv.org/content/10.1...
A MOUSE ORGANOID PLATFORM FOR MODELING CEREBRAL CORTEX DEVELOPMENT AND CIS-REGULATORY EVOLUTION IN VITRO
Natural selection has shaped the gene regulatory networks that orchestrate the development of the neocortex, leading to diverse neocortical structure and function across mammals, but the molecular and...
www.biorxiv.org
November 22, 2024 at 6:02 PM
Happy to share our mouse cortical organoid system, which recapitulates in vivo tempos and cell types. We used it to identify gene expression changes across subspecies during development, which might underlie neuroanatomical differences and affect disease penetrance. www.biorxiv.org/content/10.1...