Lara Green
@laragreen.bsky.social
Research manager at Breakthrough T1D Canada (formerly JDRF), PhD in neurophys, mom of 2 little boys, jigsaw puzzle enthusiast, enjoyer of wine and food!
Thanks to @stemcellnetwork.ca for a fantastic #TMM2025 conference.
Highlights:
🎉 Celebrating our partnership with SCN @breakthrought1dca.bsky.social
📝 Learning about regenerative medicine updates in #T1D
💭 Thought-provoking sessions on science funding, policy, and commercialization
Highlights:
🎉 Celebrating our partnership with SCN @breakthrought1dca.bsky.social
📝 Learning about regenerative medicine updates in #T1D
💭 Thought-provoking sessions on science funding, policy, and commercialization
November 8, 2025 at 2:00 PM
Thanks to @stemcellnetwork.ca for a fantastic #TMM2025 conference.
Highlights:
🎉 Celebrating our partnership with SCN @breakthrought1dca.bsky.social
📝 Learning about regenerative medicine updates in #T1D
💭 Thought-provoking sessions on science funding, policy, and commercialization
Highlights:
🎉 Celebrating our partnership with SCN @breakthrought1dca.bsky.social
📝 Learning about regenerative medicine updates in #T1D
💭 Thought-provoking sessions on science funding, policy, and commercialization
Reposted by Lara Green
Official posting coming soon, but here's a heads-up:
#Postdoc Opportunity for individuals with an interest in advancing the understanding of pancreatic islet hormones in health and #diabetes. Diverse backgrounds, skill sets and experiences are welcome!
www.bcell.org
#Postdoc Opportunity for individuals with an interest in advancing the understanding of pancreatic islet hormones in health and #diabetes. Diverse backgrounds, skill sets and experiences are welcome!
www.bcell.org
July 24, 2025 at 10:00 PM
Official posting coming soon, but here's a heads-up:
#Postdoc Opportunity for individuals with an interest in advancing the understanding of pancreatic islet hormones in health and #diabetes. Diverse backgrounds, skill sets and experiences are welcome!
www.bcell.org
#Postdoc Opportunity for individuals with an interest in advancing the understanding of pancreatic islet hormones in health and #diabetes. Diverse backgrounds, skill sets and experiences are welcome!
www.bcell.org
Last week, Breakthrough T1D Canada had the privilege of co-hosting a workshop with Canada’s Stem Cell Network and Shift Health focused on a critical and complex topic:
"Unlocking Access for Type 1 Diabetes Cell Therapies in Canada: Identifying Solutions for Regulatory and Reimbursement Success."
"Unlocking Access for Type 1 Diabetes Cell Therapies in Canada: Identifying Solutions for Regulatory and Reimbursement Success."
July 3, 2025 at 2:54 PM
Last week, Breakthrough T1D Canada had the privilege of co-hosting a workshop with Canada’s Stem Cell Network and Shift Health focused on a critical and complex topic:
"Unlocking Access for Type 1 Diabetes Cell Therapies in Canada: Identifying Solutions for Regulatory and Reimbursement Success."
"Unlocking Access for Type 1 Diabetes Cell Therapies in Canada: Identifying Solutions for Regulatory and Reimbursement Success."
‘Official’ results from the Vertex VX-880 trial using stem cell-derived islets for people with type 1 diabetes #T1D
10 out of 12 people with reduced or eliminated need for insulin 🎉
But note the need for immunosuppression and limited eligibility… this is not (YET) the ‘cure for everyone’
10 out of 12 people with reduced or eliminated need for insulin 🎉
But note the need for immunosuppression and limited eligibility… this is not (YET) the ‘cure for everyone’
Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes | NEJM
Zimislecel is an allogeneic stem cell–derived islet-cell therapy. Data on the safety
and efficacy of zimislecel in persons with type 1 diabetes are needed. We conducted
a phase 1–2 study of zimisle...
www.nejm.org
June 22, 2025 at 12:02 PM
‘Official’ results from the Vertex VX-880 trial using stem cell-derived islets for people with type 1 diabetes #T1D
10 out of 12 people with reduced or eliminated need for insulin 🎉
But note the need for immunosuppression and limited eligibility… this is not (YET) the ‘cure for everyone’
10 out of 12 people with reduced or eliminated need for insulin 🎉
But note the need for immunosuppression and limited eligibility… this is not (YET) the ‘cure for everyone’
Excellent to see this Breakthrough T1D and CIHR-funded research by Dr. Mahmud at SickKids (Toronto) that shows improved glycemic control and kidney function when using the drug dapagliflozin in youth.
Exciting to see research progress toward adjunctive therapies for #T1D.
Exciting to see research progress toward adjunctive therapies for #T1D.
Clinical trial shows improved health outcomes for teens with type 1 diabetes
A clinical trial involving adolescents with type 1 diabetes (T1D) has found a combination therapy may reduce chronic kidney disease and improve health outcomes. The findings could help guide more prec...
temertymedicine.utoronto.ca
June 19, 2025 at 11:17 PM
Excellent to see this Breakthrough T1D and CIHR-funded research by Dr. Mahmud at SickKids (Toronto) that shows improved glycemic control and kidney function when using the drug dapagliflozin in youth.
Exciting to see research progress toward adjunctive therapies for #T1D.
Exciting to see research progress toward adjunctive therapies for #T1D.
📣 Calling all trainees and early-career researchers studying type 1 diabetes #T1D
Breakthrough T1D has postdoctoral fellowships and early careers awards for academics and clinician-scientists.
🗓️ Proposals due July 1
International applicants welcome!
www.breakthrought1d.org/explore-rese...
Breakthrough T1D has postdoctoral fellowships and early careers awards for academics and clinician-scientists.
🗓️ Proposals due July 1
International applicants welcome!
www.breakthrought1d.org/explore-rese...
Type 1 Diabetes Funding Opportunities - Breakthrough T1D
Explore Breakthrough T1D’s funding opportunities for type 1 diabetes research. Learn how we support innovative projects driving breakthroughs in T1D treatment, prevention, and cures.
www.breakthrought1d.org
May 25, 2025 at 4:21 PM
📣 Calling all trainees and early-career researchers studying type 1 diabetes #T1D
Breakthrough T1D has postdoctoral fellowships and early careers awards for academics and clinician-scientists.
🗓️ Proposals due July 1
International applicants welcome!
www.breakthrought1d.org/explore-rese...
Breakthrough T1D has postdoctoral fellowships and early careers awards for academics and clinician-scientists.
🗓️ Proposals due July 1
International applicants welcome!
www.breakthrought1d.org/explore-rese...
What a legacy 🇨🇦 Drs. Till & McCulloch discovered stem cells in the 60s which changed the future of regenerative medicine and contributed to solving one of the biggest hurdles (having enough cells) in the quest to cure type 1 diabetes
#T1D #stemcell
#T1D #stemcell
(1/3) It is with profound sadness that we honour the passing of Dr. James Till, a pioneering Canadian scientist whose work, alongside Dr. Ernest McCulloch, laid the very foundation of stem cell research.
stemcellnetwork.ca/celebrating-...
stemcellnetwork.ca/celebrating-...
May 23, 2025 at 10:16 PM
A short (12-min) interview about the current and future of islet transplantation. Worth a listen for anyone interested in learning more about cures for #T1D
🎙️The future of #T1D care: Are we closing in on a cell-based cure?
From islet transplants to stem cell-derived therapies, experts Dr James Shaw, Dr Timothy Kieffer & Dr Trevor Reichman explore the cutting edge of regenerative diabetes treatment.
🎧Listen now 👉 www.easd.org/media-centre...
From islet transplants to stem cell-derived therapies, experts Dr James Shaw, Dr Timothy Kieffer & Dr Trevor Reichman explore the cutting edge of regenerative diabetes treatment.
🎧Listen now 👉 www.easd.org/media-centre...
May 9, 2025 at 3:12 PM
A short (12-min) interview about the current and future of islet transplantation. Worth a listen for anyone interested in learning more about cures for #T1D
Yesterday, Health Canada approved the first disease-modifying therapy for type 1 diabetes #T1D. This is a ‘preventative’ (actually ‘delaying’) therapy that addresses autoimmunity *before* someone is diagnosed and requiring insulin.
breakthrought1d.ca/news/health-...
breakthrought1d.ca/news/health-...
Health Canada approves Tzield – the first ever disease modifying therapy for type 1 diabetes | Breakthrough T1D
On May 5, 2025, Sanofi announced Health Canada approval of Tzield, the first disease-modifying therapy for type 1 diabetes (T1D). This is a huge win for the T1D community in that it is the first medic...
breakthrought1d.ca
May 6, 2025 at 8:34 PM
Yesterday, Health Canada approved the first disease-modifying therapy for type 1 diabetes #T1D. This is a ‘preventative’ (actually ‘delaying’) therapy that addresses autoimmunity *before* someone is diagnosed and requiring insulin.
breakthrought1d.ca/news/health-...
breakthrought1d.ca/news/health-...
Reposted by Lara Green
Several BreakthroughT1D funding opportunities available
1) Advancing GRS, especially in non-European backgrounds
2) Early detection in adult-onset T1D
3) Tech for scaling manufactured islets
Feel free to reach out with questions. Open to industry and academia
#funding #grants #T1D
1) Advancing GRS, especially in non-European backgrounds
2) Early detection in adult-onset T1D
3) Tech for scaling manufactured islets
Feel free to reach out with questions. Open to industry and academia
#funding #grants #T1D
Type 1 Diabetes Funding Opportunities - Breakthrough T1D
Explore Breakthrough T1D’s funding opportunities for type 1 diabetes research. Learn how we support innovative projects driving breakthroughs in T1D treatment, prevention, and cures.
www.breakthrought1d.org
May 6, 2025 at 8:19 PM
Beyond the Numbers: Real Stories of Navigating Mental Health with type 1 diabetes #T1D. This powerful new video series shares the honest, emotional stories of adults living with type 1 diabetes. 💙
🔗 Watch the series ow.ly/aqb950VKwkL
🔗 Explore mental health & T1D resources ow.ly/J49v50VKwkK
🔗 Watch the series ow.ly/aqb950VKwkL
🔗 Explore mental health & T1D resources ow.ly/J49v50VKwkK
Beyond the Numbers: Real Stories of Navigating Mental Health with T1D | Au-delà des chiffres : De vraies histoires sur la santé mentale avec le DT1 - YouTube
ow.ly
May 5, 2025 at 4:56 PM
Beyond the Numbers: Real Stories of Navigating Mental Health with type 1 diabetes #T1D. This powerful new video series shares the honest, emotional stories of adults living with type 1 diabetes. 💙
🔗 Watch the series ow.ly/aqb950VKwkL
🔗 Explore mental health & T1D resources ow.ly/J49v50VKwkK
🔗 Watch the series ow.ly/aqb950VKwkL
🔗 Explore mental health & T1D resources ow.ly/J49v50VKwkK
Great new research - one of the difficult aspects of #T1D is that there’s no way to “see” islet or beta cells to check if they are being attacked or functioning well so new biomarkers are important!
(More info in comments…)
(More info in comments…)
#T1D Research Report Findings: "M120 identified 26% more children at high risk of progression" of #Type1Diabetes.
"M120 Risk Score Improves Identification of Children at High Risk of Developing Clinical Type 1 Diabetes and Reports Short-Term Response to Preventive Immunotherapy" bit.ly/4jwYfGL
"M120 Risk Score Improves Identification of Children at High Risk of Developing Clinical Type 1 Diabetes and Reports Short-Term Response to Preventive Immunotherapy" bit.ly/4jwYfGL
M120 Risk Score Improves Identification of Children at High Risk of Developing Clinical Type 1 Diabetes and Reports Short-Term Response to Preventive Immunotherapy
OBJECTIVE. Approval of teplizumab as disease-modifying therapy for type 1 diabetes heralds a new therapeutic era. To facilitate prevention trials, we deter
bit.ly
April 15, 2025 at 6:00 PM
Great new research - one of the difficult aspects of #T1D is that there’s no way to “see” islet or beta cells to check if they are being attacked or functioning well so new biomarkers are important!
(More info in comments…)
(More info in comments…)
So much knowledge comes from a registry - this is a catalyst for many other research projects and often helps guide research priorities!
If you (or your child) lives with type 1 diabetes #T1D #LADA and are located in Canada 🇨🇦, PLEASE consider contributing to research! (Completely virtual too).
If you (or your child) lives with type 1 diabetes #T1D #LADA and are located in Canada 🇨🇦, PLEASE consider contributing to research! (Completely virtual too).
🎉 5,000 people have joined the BETTER registry! 🎉
Thanks to you, research is moving forward and we’re improving our understanding of the realities faced by people living with type 1 diabetes and LADA in Canada.
#type1diabetes #BETTERregistry #diabetesresearch #T1D #LADA #Canada #PatientVoices
Thanks to you, research is moving forward and we’re improving our understanding of the realities faced by people living with type 1 diabetes and LADA in Canada.
#type1diabetes #BETTERregistry #diabetesresearch #T1D #LADA #Canada #PatientVoices
The BETTER registry reaches 5,000 participants – BETTER
We’re excited to share a major milestone for the BETTER project: more than 5,000 people living with type 1 diabetes (T1D) or latent autoimmune diabetes in adults (LADA) in Canada have joined the BETTE...
type1better.com
April 14, 2025 at 1:18 PM
Adult living with #T1D in Edmonton, #Canada…?
Consider participating in clinical trials to explore new therapies.
Not in Edmonton - look for other actively recruiting trials for type 1 diabetes here clinicaltrials.breakthrought1d.ca/search
Consider participating in clinical trials to explore new therapies.
Not in Edmonton - look for other actively recruiting trials for type 1 diabetes here clinicaltrials.breakthrought1d.ca/search
April 10, 2025 at 11:33 AM
Adult living with #T1D in Edmonton, #Canada…?
Consider participating in clinical trials to explore new therapies.
Not in Edmonton - look for other actively recruiting trials for type 1 diabetes here clinicaltrials.breakthrought1d.ca/search
Consider participating in clinical trials to explore new therapies.
Not in Edmonton - look for other actively recruiting trials for type 1 diabetes here clinicaltrials.breakthrought1d.ca/search
Reposted by Lara Green
www.nature.com/naturecareer... UBC LSI Job!!
Assistant Professor (tenure track) – Chromatin, Epigenetics - Vancouver, British Columbia (CA) job with The University of British Columbia (UBC) | 12837841
Assistant Professor (tenure track) - Chromatin Regulation, Genetic Regulatory Mechanisms, Epigenetics, Epigenomics
www.nature.com
April 4, 2025 at 4:03 AM
www.nature.com/naturecareer... UBC LSI Job!!
VERY important research from the fantastic Dr. Jane Speight.
The burden of self-managed chronic conditions should not be underestimated!
If you live in Canada and want to find a mental health worker that understands diabetes burden ( #T1D or #T2D) - check on our directory.breakthrought1d.ca
The burden of self-managed chronic conditions should not be underestimated!
If you live in Canada and want to find a mental health worker that understands diabetes burden ( #T1D or #T2D) - check on our directory.breakthrought1d.ca
April 2, 2025 at 11:58 AM
VERY important research from the fantastic Dr. Jane Speight.
The burden of self-managed chronic conditions should not be underestimated!
If you live in Canada and want to find a mental health worker that understands diabetes burden ( #T1D or #T2D) - check on our directory.breakthrought1d.ca
The burden of self-managed chronic conditions should not be underestimated!
If you live in Canada and want to find a mental health worker that understands diabetes burden ( #T1D or #T2D) - check on our directory.breakthrought1d.ca
Unfortunate to see today’s news from Vertex about their VX-264 therapy for #T1D but this is why we always have ‘multiple shots on goal’!
Considering that the same cells are being used as in VX-880 (so far great data) it’s reasonable to assume that the device encapsulation was the problem here.
Considering that the same cells are being used as in VX-880 (so far great data) it’s reasonable to assume that the device encapsulation was the problem here.
March 28, 2025 at 9:02 PM
Unfortunate to see today’s news from Vertex about their VX-264 therapy for #T1D but this is why we always have ‘multiple shots on goal’!
Considering that the same cells are being used as in VX-880 (so far great data) it’s reasonable to assume that the device encapsulation was the problem here.
Considering that the same cells are being used as in VX-880 (so far great data) it’s reasonable to assume that the device encapsulation was the problem here.
Always exciting to see new Clinical Practice Guidelines, but these are especially exciting:
- T1D across the lifetime instead of broken up into stages 👏
- recommending AID for all ages and stages of T1D 👏👏
- first in the world to recommend considering the use of adjunctive therapies for T1D 👏👏👏
- T1D across the lifetime instead of broken up into stages 👏
- recommending AID for all ages and stages of T1D 👏👏
- first in the world to recommend considering the use of adjunctive therapies for T1D 👏👏👏
March 27, 2025 at 9:14 PM
Always exciting to see new Clinical Practice Guidelines, but these are especially exciting:
- T1D across the lifetime instead of broken up into stages 👏
- recommending AID for all ages and stages of T1D 👏👏
- first in the world to recommend considering the use of adjunctive therapies for T1D 👏👏👏
- T1D across the lifetime instead of broken up into stages 👏
- recommending AID for all ages and stages of T1D 👏👏
- first in the world to recommend considering the use of adjunctive therapies for T1D 👏👏👏
Really fascinating debate at #ATTD2025 about whether or not we should use placebos in trial design for preventative therapies of #T1D now that Tzield (teplizumab) has shown efficacy and is approved in a few countries. Heavy hitters Colin Dayan and Laura Jacobsen presented excellent points!
March 22, 2025 at 1:38 PM
This is so powerful… “Has your diabetes been impacted by menopause?” 88% say YES!
Research is starting to grow in this area: to see Canadian trials related to menopause and #T1D check out our Clinical Trial Finder clinicaltrials.breakthrought1d.ca
Research is starting to grow in this area: to see Canadian trials related to menopause and #T1D check out our Clinical Trial Finder clinicaltrials.breakthrought1d.ca
March 21, 2025 at 1:49 AM
This is so powerful… “Has your diabetes been impacted by menopause?” 88% say YES!
Research is starting to grow in this area: to see Canadian trials related to menopause and #T1D check out our Clinical Trial Finder clinicaltrials.breakthrought1d.ca
Research is starting to grow in this area: to see Canadian trials related to menopause and #T1D check out our Clinical Trial Finder clinicaltrials.breakthrought1d.ca
Thrilled to (virtually) watch a fantastic talk at #ATTD2025 from Dr. Cristina Nostro about co-culturing pluripotent stem cells with macrophages which not only provides protection but also increases endocrine output!
March 20, 2025 at 12:46 PM
Thrilled to (virtually) watch a fantastic talk at #ATTD2025 from Dr. Cristina Nostro about co-culturing pluripotent stem cells with macrophages which not only provides protection but also increases endocrine output!
www.linkedin.com/posts/emily-...
Great post for a very insightful study. IA-2A positive individuals will need close monitoring for #T1D progression!
Great post for a very insightful study. IA-2A positive individuals will need close monitoring for #T1D progression!
Emily Sims on LinkedIn: What's up with IA2A?! Excited to share this collaborative work in…
What's up with IA2A?! Excited to share this collaborative work in Diabetologia showing that IA-2A+ is consistently linked to increased disease progression…
www.linkedin.com
March 3, 2025 at 7:46 PM
www.linkedin.com/posts/emily-...
Great post for a very insightful study. IA-2A positive individuals will need close monitoring for #T1D progression!
Great post for a very insightful study. IA-2A positive individuals will need close monitoring for #T1D progression!
📣Students and postdocs, consider Canadian universities for grad studies! Tuition is typically offset by teaching assistantships for seminars/labs, and applying is as simple as making contact with a PI to start. If you’re in the field of #T1D - reach out if you’d like us to help make a connection!
It’s pretty easy to “apply” for a PhD in Canada, and a little different from most US places, just send a cover letter, CV and undergrad transcript to a PI you’d like to work with. Put some effort into it, make sure you convey what you’re applying for and why.
Many US students don’t know how to seek opportunities outside the US. With some help from our colleagues in EU and Canada, we could put together a consolidated website of PhD opportunities and scholarships outside the US, organized by field. There might still be time for this year in some places.
March 2, 2025 at 2:11 PM
📣Students and postdocs, consider Canadian universities for grad studies! Tuition is typically offset by teaching assistantships for seminars/labs, and applying is as simple as making contact with a PI to start. If you’re in the field of #T1D - reach out if you’d like us to help make a connection!
Registries are such a critical accelerator for research! If you or someone you know in Canada lives with #T1D, please consider being a part of the BETTER Registry!
🔬 A study is currently underway using data from the BETTER registry to explore other autoimmune diseases in type 1 diabetes and the associated risks. 💙
Join the registry now if you (or your child) live with type 1 diabetes or LADA in Canada 🇨🇦
🔗 type1better.com/en/the-bette...
#T1D #research
Join the registry now if you (or your child) live with type 1 diabetes or LADA in Canada 🇨🇦
🔗 type1better.com/en/the-bette...
#T1D #research
February 20, 2025 at 8:24 PM
Registries are such a critical accelerator for research! If you or someone you know in Canada lives with #T1D, please consider being a part of the BETTER Registry!
Reposted by Lara Green
I have funding through at least 2031 for postdoctoral researchers with expertise in islet biology or cell-based therapies for, or modelling of, diabetes. Bring your expertise to a country that values it. 🇨🇦
Contact info on my website.
Contact info on my website.
February 15, 2025 at 4:40 PM
I have funding through at least 2031 for postdoctoral researchers with expertise in islet biology or cell-based therapies for, or modelling of, diabetes. Bring your expertise to a country that values it. 🇨🇦
Contact info on my website.
Contact info on my website.