Andy Lane
lane-andy.bsky.social
Andy Lane
@lane-andy.bsky.social
Leukemia physician and anti-cancer scientist @Dana-Farber #AML #MDS #CMML #ALL #BPDCN
Reposted by Andy Lane
How I treat blastic plasmacytoid dendritic cell neoplasm
https://buff.ly/4aSEkid #HowITreat #MyeloidNeoplasia
February 11, 2025 at 1:00 PM
Reposted by Andy Lane
Here's our latest, led by Drs. Riaz Gillani & Ryan Collins - we studied a type of inherited genetic event (structural variants) + risk of developing certain cancers in kids:
@danafarber.bsky.social @bostonchildrens.bsky.social @broadinstitute.org @science.org

www.science.org/doi/10.1126/...
Rare germline structural variants increase risk for pediatric solid tumors
Pediatric solid tumors are a leading cause of childhood disease mortality. In this work, we examined germline structural variants (SVs) as risk factors for pediatric extracranial solid tumors using ge...
www.science.org
January 2, 2025 at 11:38 PM
Reposted by Andy Lane
What is the role of lactate accumulation in tumor growth and metastasis?

@echouchani.bsky.social is using his Emerging Leader Award from The Mark Foundation to find out.

Check out this new feature from @danafarber.bsky.social to learn more about his work!
danafarberimpact.org/2024/12/canc...
Cancer biologist Edward Chouchani receives Emerging Leader grant - Impact Magazine
The Mark Foundation grant advances groundbreaking research into the role of lactate in controlling cell proliferation at Dana-Farber.
danafarberimpact.org
January 5, 2025 at 8:20 PM
Cool new target and biology in AML from Yoke and Peter @vangalenlab.bsky.social. Happy to have seen this story grow.
Our latest work is now available to read on bioRxiv! Very proud of this and its potential implications for patients with acute myeloid leukemia 🩸 🧪 🔬💊 **eIF4A-mediated translation initiation as an AML cell vulnerability that can be co-targeted with BCL-2 inhibition** www.biorxiv.org/content/10.1...
December 23, 2024 at 3:35 PM
Reposted by Andy Lane
Our latest work is now available to read on bioRxiv! Very proud of this and its potential implications for patients with acute myeloid leukemia 🩸 🧪 🔬💊 **eIF4A-mediated translation initiation as an AML cell vulnerability that can be co-targeted with BCL-2 inhibition** www.biorxiv.org/content/10.1...
December 23, 2024 at 12:54 PM
Reposted by Andy Lane
Thrilled to share a wonderful collaboration with Scott Armstrong, Florian Perner & Shellaina Gordon - exciting times ahead!

www.biorxiv.org/content/10.1...
Catalytic inhibition of KAT6/KAT7 enhances the efficacy and overcomes primary and acquired resistance to Menin inhibitors in MLL leukaemia
Understanding the molecular pathogenesis of MLL fusion oncoprotein (MLL-FP) leukaemia has spawned epigenetic therapies that have improved clinical outcomes in this often-incurable disease. Using genet...
www.biorxiv.org
December 13, 2024 at 9:07 PM
Reposted by Andy Lane
New insights in #AML and #BPDCN care with Shai Shimony @danafarber.bsky.social at #ASH24 🎥

⭐AML-MR mutations drive CPX-351's benefit over 7+3
⭐Machine learning identifies a 3-parameter survival model for BPDCN
⭐Social determinants of health impact survival in AML across ELN risk groups
December 8, 2024 at 6:54 PM
Here are the top line overall survival (OS) data with the new #BPDCN 3-parameter prognostic model by Shai Shimony from our BPDCN Center: Favorable, 100% 2-year OS; intermediate, 39% OS and median 21.1 months; adverse, 5% OS and median 9.9 months (factors: age, marrow involvement, signaling mut)
December 8, 2024 at 2:20 AM
Come see a session about clinical outcomes in #BPDCN, including a machine learning model that has generated a clinically useful and simple 3 factor prognostic scoring model for survival in the disease by superstar new faculty member Shai Shimony @danafarber.bsky.social
December 8, 2024 at 12:10 AM
Reposted by Andy Lane
8 days ago, ASH decided to join Bluesky. 🌤️ So far, we're enjoying fewer distractions & more meaningful connections. 💬 Engaging with our amazing #hematology and #hemeonc communities has never been easier.

We created an #ASH24 feed for you & we have more feeds coming soon: bit.ly/ASH24feed

#Hemesky
November 29, 2024 at 7:46 PM
Venetoclax-bortezomib-dexamethasone for unfit BPDCN from our French colleagues: pubmed.ncbi.nlm.nih.gov/39642332/
Venetoclax-Proteasome inhibitor-Dexamethasone for unfit patients with Blastic Plasmacytoid Dendritic Cell Neoplasm - PubMed
Venetoclax-Proteasome inhibitor-Dexamethasone for unfit patients with Blastic Plasmacytoid Dendritic Cell Neoplasm
pubmed.ncbi.nlm.nih.gov
December 7, 2024 at 7:03 PM
Reposted by Andy Lane
We just opened a search for a lab-based faculty position at Dana-Farber @danafarber.bsky.social @harvardmed.bsky.social

Any area of cancer research is fair game and MD, PhD, or MD/PhD are encouraged to apply.
Please spread the word:
www.nejmcareercenter.org/job/829239/l...
Laboratory-based Investigator, Faculty Search - Boston, Massachusetts job with Dana-Farber Cancer Institute | 829239
Laboratory-based Investigator, Faculty Search The Department of Medical Oncology at the Dana-Farber Cancer Institute (DFCI) and the Brigham and Wom...
www.nejmcareercenter.org
December 3, 2024 at 1:46 AM
Reposted by Andy Lane
Not sure if I can handle another platform but will give this a whirl at #ASH2024. See everyone in San Diego.
December 5, 2024 at 5:55 PM