Wrapping up with Emmanuelle Six on Gene Therapy. 🧬
Chronic inflammation "exhausts" our blood stem cells (HSPCs), making them less fit for genetic engineering. Emmanuelle is sharing solutions to protect stem cell fitness, ensuring that life-saving gene therapies work better and last longer. 🧪

Thiago Trovati is discussing a creative approach to Sickle Cell Disease (SCD): drug repurposing. 🔄

Focusing on Acute Chest Syndrome (a life-threatening complication), he’s exploring how drugs like tocilizumab, might help SCD patients by addressing ineffective erythropoiesis.🩸 #Hematology #SCD

Deep dive into the gut with David Skurnik (INEM). He has identified Oxalyl-CoA decarboxylase as a critical "survival tool" for Adherent Invasive E. coli (AIEC) in the harsh, acidic environment of the inflamed gut. 🦠

Next, Marie Louise Frémond talking about interferonopathies. These rare genetic disorders are driven by an "overdose" of type I interferon.
She's highlighting the efficacy of Anifrolumab—an IFNAR1 receptor blocker. Results show a significant "normalization" of the interferon signature in patients. 💊

Closing today's session is Amine Toubal (INEM).
He is decoding the immunometabolic pathways that govern wound healing in Type 2 diabetes. Crucial work for understanding complications in metabolic disorders. 🩹🍬
That’s a wrap for this week’s meeting! See you all next week for more science!

Next, we are looking at the lungs with Mairead Aubert (INEM). 🫁
Her talk focuses on the "Metabolic Control of Airway Epithelial Repair," specifically in the context of Cystic Fibrosis and beyond. Understanding repair mechanisms is key! 🌬️

Welcoming Lucie Peduto from @pasteur.fr! 🏛️
She is diving into the role of stromal lineages in tissue homeostasis and disease. A fascinating look at the structural support systems of our biology.
#biology #research

🦠 Closing our session is @manusingh.bsky.social discussing the "Long Shadow of Viral Infections".
He's showing how HIV & EBV can reactivate persistent, ancient Endogenous Retroviral proteins. A powerful reminder that our genome's history still dictates our health today!🧬

Moving to autoimmunity with Anaïs Levescot 🛡️
Her talk focuses on somatic clonal evolution of tissue-resident lymphocytes in chronic autoimmunity. Takeaway: Chronic activation isn't just inflammation, it's a pathogenic continuum where somatic mutations drive tissue damage and treatment resistance. 🧬

Next, Katrina Podsypanina (B. Manoury Lab, @inem-necker.bsky.social ) takes the stage to discuss a fascinating evolutionary link. She is exploring how Ancient Endogenous Retroviruses might be the missing link between maternal tolerance and how tumors evade the immune system. 🤰🧪

Closing the session with Hugo Malki from the Dalkara Lab at Institut Vision! 👁️
Hugo is presenting on editing approaches for eye disorders. He highlights the use of retinal organoids to test gene editing efficiency for retinal therapies. That’s a wrap on the first MAGIC session of 2026! 🎬

Next, Edor Kabashi takes us into the nervous system. 🧠 He is discussing editing approaches for ALS and SMA (Spinal Muscular Atrophy). Edor’s team uses zebrafish models and patient-derived iPSCs to validate these novel therapeutic targets for motor neuron diseases.