🫁 New study by Hermine Lab at Institut Imagine finds Acute Chest Syndrome is driven by local lung complement activation.
Analyzing "golden sputum" paves the way for new anti-complement trials in #SickleCell. 🩸

Read more: onlinelibrary.wiley.com/doi/10.1002/...

Fier de voir nos recherches en thérapie génique dans le Top 10 des percées 2026 de L'Express ! 🚀

Un immense bravo à la Pr Marina Cavazzana et nos équipes. Notre objectif : passer à la vitesse supérieure pour les familles touchées par des maladies rares.

À lire ici : www.lexpress.fr/sciences-san...

Closing the session with Hugo Malki from the Dalkara Lab at Institut Vision! 👁️
Hugo is presenting on editing approaches for eye disorders. He highlights the use of retinal organoids to test gene editing efficiency for retinal therapies. That’s a wrap on the first MAGIC session of 2026! 🎬

Next, Edor Kabashi takes us into the nervous system. 🧠 He is discussing editing approaches for ALS and SMA (Spinal Muscular Atrophy). Edor’s team uses zebrafish models and patient-derived iPSCs to validate these novel therapeutic targets for motor neuron diseases.

Moving on to the skin as a target organ. 🧬 Araksya Izmiryan presents her work on editing approaches for severe skin disorders, particularly Recessive Dystrophic Epidermolysis Bullosa. Her research on restoring gene function is critical for these painful and debilitating conditions. #skindisease

Next, we are delighted to welcome our guest speaker, Mario Amendola from @genethonfr.bsky.social! 🤝 An expert in gene transfer tools, Mario is sharing his innovative strategies for treating muscle disorders.

We are live from our weekly MAGIC meeting! 🧬
First up, Annarita Miccio sets the stage! 🩸 She is introducing the session and discussing editing approaches for hemoglobinopathies. Her team’s work on Sickle Cell Disease is paving the way for next-gen therapies for blood.
#sicklecelldisease

Does a neuron’s "address" define its function? 🧠
Featured in @lefigaro.fr, new nature neuroscience research from Denis Jabaudon & colleagues shows that misplaced neurons can work perfectly & process senses. Brain structure ≠ function!
For more information: www.linkedin.com/posts/instit...

Kicking off 2026 with our first Monday Seminar! 🧬
How do we find proteins "missing" in human tissue? 🔍
Dr. Leon Peshkin (Harvard Medical School) is live, discussing a how to build a "periodic table" of cell types using Xenopus to map elusive proteins across development & their clinical potential. 🐸🏥

🗓️ Jusqu’au 31 décembre, vous avez le pouvoir changer des vies. En France, 64 enfants par jour naissent avec une maladie génétique rare.

Faites un don pour soutenir la recherche sur les maladies génétiques 👉 vaincre-les-maladies-genetiques.institutimagine.org

Ending the session with a look at experimental design with Emeline Perthame (@institutpasteur.bsky.social). 🐁
"Reducing sex bias in projects involving animals: approaches implemented and in progress at Institut Pasteur."
Improving reproducibility starts with better representation in animal models!

Next, we welcome @darraghduffy.bsky.social from @institutpasteur.bsky.social! 🦠
He is tackling a complex challenge in immunology: "Challenges of disentangling sex and gender effects on immunity."
Vital work for understanding why immune responses differ between men and women. 🛡️📉
#Immunology

📢 We are live for this week’s MAGIC scientific meeting! Today we are addressing Sex and Gender Bias in biomedical research. 🧬
First up is Pauline Chaste from Institut Imagine regarding ASD.
"Leveraging Clinical Narratives together with Genomics to overcome gender bias in ASD risk prediction."

Final talk of the day!📊
Chiara Guerrera from the SFR Necker Proteomics Platform is here to answer the question: "How Proteomics can help you with your STRESS?"
A perfect overview of how proteomic analysis supports relevant research projects on campus. 🔎 #Proteomics #SFRNecker #ResearchTools

Now presenting: Edor Kabashi (Institut Imagine) on the mechanisms of ALS. 🦠
Title: "TBK1 at the interface between stress granules and ALS". Edor is breaking down the link between cellular stress granules and neurodegeneration. #ALS #Neurodegeneration

Moving to developmental biology with Nadège Bondurand from Imagine!🧠
She is sharing her latest findings on the "Activation of ISR upon Adar1 invalidation during Schwann cells development." Fascinating look at how integrated stress response activation impacts the nervous system.💡

Next, we dive into cancer immunology with Jozef Bossowski (@inem-necker.bsky.social). 🫁
He is presenting his work on "From Cellular Stress to Immune Escape: The Emerging Role of Lipocalin-2 in Lung Cancer." Critical insights into how tumor cells evade the immune system! 🛡️🔬 #Oncology #InstitutImagine

🚀 Starting now! We're kicking off our weekly MAGIC scientific meeting with a packed agenda on stress and consequences. First up, Julien Fouchet from @inem-necker.bsky.social takes the stage to discuss the regulation of Unfolded Protein Response (UPR). #Science #ScienceSky #InstitutImagine