Lakshmi Balasubramaniam
@lakshmib02.bsky.social
Herchel Smith/ EMBO Postdoctoral fellow at the Gurdon Institute working on mechanics and embryogenesis at Xiong lab. PhD @Ladoux MegeLab, Paris. Cell migration, adhesion and biophysics aficionado.
Thank you so much Benoit
April 10, 2025 at 3:54 PM
Thank you so much Benoit
Congrats Pu. It looks really nice :)
March 12, 2025 at 1:31 PM
Congrats Pu. It looks really nice :)
a better link to the published version: rdcu.be/d5AD6
Dynamic forces shape the survival fate of eliminated cells
Nature Physics - Tissues eliminate unwanted cells through cell extrusion, but the factors determining whether these extuded cells live or die are not fully understood. Now force transmission across...
rdcu.be
January 8, 2025 at 11:28 AM
a better link to the published version: rdcu.be/d5AD6
See another beautiful example of how these cells regulate forces at the interface of differential adhesion here bsky.app/profile/andr...
Thrilled to share our new manuscript on how force transmission can regulate mechanical cell competition!
Fun collaboration between the @bladoux.bsky.social / @rmmege.bsky.social and the Doostmohammadi group combining experiments and simulations.
Main points below 👇
www.biorxiv.org/content/10.1...
Fun collaboration between the @bladoux.bsky.social / @rmmege.bsky.social and the Doostmohammadi group combining experiments and simulations.
Main points below 👇
www.biorxiv.org/content/10.1...
Force transmission is a master regulator of mechanical cell competition
Cell competition is a tissue surveillance mechanism for eliminating unwanted cells and as such is indispensable in development, infection and tumorigenesis. Although different biochemical mechanisms a...
www.biorxiv.org
January 8, 2025 at 11:05 AM
See another beautiful example of how these cells regulate forces at the interface of differential adhesion here bsky.app/profile/andr...
We also have some sequencing and proteomics datasets for MDCK WT and E-cad KO cells with cell death being differentially regulated. Through a combination of phase field modeling we show that mechanical forces are able to regulate death signals in a cell through neighbour cell interactions.
January 8, 2025 at 11:03 AM
We also have some sequencing and proteomics datasets for MDCK WT and E-cad KO cells with cell death being differentially regulated. Through a combination of phase field modeling we show that mechanical forces are able to regulate death signals in a cell through neighbour cell interactions.