Sakamoto Lab
@labsakamoto.bsky.social
Metabolic Signaling Laboratory, NNF-CBMR, University of Copenhagen
Posts by @itsmedipsikha.bsky.social
Posts by @itsmedipsikha.bsky.social
Congratulations to the lead authors, to other members of the @labsakamoto.bsky.social and all other co-authors! @keisakamoto.bsky.social @zeqiraj.bsky.social @cbmr.science
September 9, 2025 at 3:17 PM
Congratulations to the lead authors, to other members of the @labsakamoto.bsky.social and all other co-authors! @keisakamoto.bsky.social @zeqiraj.bsky.social @cbmr.science
The structure of BAY-3827 with wild-type AMPK α2 kinase domain by @zeqiraj.bsky.social & postdoc Mohd. Syed Ayengar helped determine the mechanism of action of this compound and the limitations for its use, addressing a long-standing challenge in the field: the absence of specific AMPK inhibitors.
September 9, 2025 at 3:17 PM
The structure of BAY-3827 with wild-type AMPK α2 kinase domain by @zeqiraj.bsky.social & postdoc Mohd. Syed Ayengar helped determine the mechanism of action of this compound and the limitations for its use, addressing a long-standing challenge in the field: the absence of specific AMPK inhibitors.
BAY-3827 inhibited ~30% of AMPK-dependent genes in mouse primary hepatocytes and reversed AMPK-inhibited lipogenesis. 2/3
September 9, 2025 at 3:17 PM
BAY-3827 inhibited ~30% of AMPK-dependent genes in mouse primary hepatocytes and reversed AMPK-inhibited lipogenesis. 2/3