The structure of BAY-3827 with wild-type AMPK α2 kinase domain by @zeqiraj.bsky.social & postdoc Mohd. Syed Ayengar helped determine the mechanism of action of this compound and the limitations for its use, addressing a long-standing challenge in the field: the absence of specific AMPK inhibitors.

BAY-3827 inhibited ~30% of AMPK-dependent genes in mouse primary hepatocytes and reversed AMPK-inhibited lipogenesis. 2/3

Last week @labsakamoto.bsky.social members participated in the #DHL Relay Copenhagen with one running team and one walking team! This was the lab's 5th year participating in this event and each year we get better with our performance😀
& this year was @keisakamoto.bsky.social personal best 🙌🍾

Congratulations to Researcher @itsmedipsikha.bsky.social for being one of the recipients of the EFSD/Lilly Young Investigator Awards! We celebrated her achievement with some cakes and bubbles earlier 🥳 @easdnews.bsky.social @cbmr.science

www.europeandiabetesfoundation.org/recipients/e...

Last week we said goodbye to Florentina, who started as a postdoc with us in early 2020. We are truly privileged for her tenacity, hardwork & diligence that helped shape our group @cbmr.science & thank her for
guiding our junior colleagues. We wish her the best for her bright future!
.

Congratulations to all @labsakamoto.bsky.social group members for being the worthy winners of the K.I.S.S campaign! 🏆 👏 💪 Special mention to our lab manager, Marianne, for her persistence to make sure everyone gets their risk assessments done. Thanks @cbmr.science for this important initiative.

Special day for our group @cbmr.science as we celebrate the successful defense of our (first) freshly minted PhD, Dr. Conchita Bringas 🥳 Her thesis was based on characterizing novel #AMPK inhibitors. Special thanks to the great committee @rbdamgaard.bsky.social ,Dave Carling & Lykke Sylow.

Today we bid farewell our diligent & hardworking lab tech, Kaltum, as she goes on her maternity leave. We will miss having her around but we are very excited for her as she embarks on her journey of motherhood. We are looking forward to welcome the tiniest member of our group, soon 🙂

We are lucky to have incredible #diversity in our group where we learn about new cultures, languages & traditions. And what better way to learn something new than through food! Had a potluck with traditional cuisines across the globe today & evidently these scientists excel in the kitchen too!

The Sakamoto group members in action on Metabolism Day #MD25 , a 1 day international conference about energy control and metabolism organized by @cbmr.science , now in its 7th successful year!

Strong presence of the @labsakamoto.bsky.social group members at the Metabolism Day #MD25 @cbmr.science Posters were presented by postdocs Joy & Jordana and by PhD students Maria, Hongling, Conchita & Costanza. #AMPK #TFEB #SIK

Fascinating talk by Prof Gregory Radick bringing new light on the debate between Mendelian v/s Weldonian theories of inheritance and genetics. The talk highlighted the importance of re-evaluating and contextualizing the history of science during public outreach.
#MD25 @cbmr.science

Post lunch session was kick started with a fantastic talk by Dr. James Trevaskis @elilillyandcompany.bsky.social taking us on a journey about the promising current and future #obesity therapeutics. #MD25 @cbmr.science

Last talk (strategically placed) before the lunch break was by Prof. Amalia Gastadelli who talked about the relation between fibrosis severity and glucose and lipid metabolism in #MASLD
#MD25

Prof. Ingela Lanekoff at Uppsala gave a masterclass on new technologies taking spatial #metabolomics to new heights, in the second talk of the day before we break for the first poster session #MD25 @cbmr.science

The first talk was by Prof. Anu Suomalainen-Wartiovaara from the @helsinkiupress.bsky.social who gave fascinating insights into mitochondrial mechanisms of neurodenerative diseases, highlighting that mitochondrial defects can be local, systemic & context dependent. #MD25

Starting now @cbmr.science organised Metabolism Day, A conference about everything energy control and metabolism. An exciting day ahead packed with stellar speakers & cutting edge science. It's also being streamed live om YouTube. #MD25

Our group @cbmr.science is now driven by an all women workforce (barring Kei), & we are incredibly fortunate to have these (multi)talented, hard working & generous women who support & elevate each other every day!
Happy International Women's Day!
#WomensDay2025 #LatePost