IMAGE Lab
@labphan.bsky.social
B cells | Macrophages | Immunity | Autoimmunity | Cancer | Osteoclasts | Osteomorphs | Intravital imaging | Precision Immunology
Yea but how big was the photon? 😅
October 9, 2025 at 7:36 AM
Yea but how big was the photon? 😅
Nice one congrats John et al!
July 31, 2025 at 8:22 AM
Nice one congrats John et al!
Much obliged will do. 😊
June 26, 2025 at 9:58 PM
Much obliged will do. 😊
But sc data is noisy and nonlinear. AAnet takes archetype analysis to the next level by using an autoencoder to transform the data into a simplicial latent space. AAnet more accurately defines heterogeneity within cellular clusters & druggable transcriptional programs that drive heterogeneity. 3/3
June 26, 2025 at 11:38 AM
But sc data is noisy and nonlinear. AAnet takes archetype analysis to the next level by using an autoencoder to transform the data into a simplicial latent space. AAnet more accurately defines heterogeneity within cellular clusters & druggable transcriptional programs that drive heterogeneity. 3/3
Cells exist in discrete cell states (clusters) but also cells show a continuum of gene expression (trajectory). @urialonlab.bsky.social first used archetype analysis to reconcile this paradox - the bioinformatic equivalent of wave-particle duality. This works if the ambient data space is linear. 2/3
Continuum of Gene-Expression Profiles Provides Spatial Division of Labor within a Differentiated Cell Type
Single-cell gene expression reveals the diversity within a differentiated cell type. Often, cells of the same type show a continuum of gene-expression…
www.sciencedirect.com
June 26, 2025 at 11:38 AM
Cells exist in discrete cell states (clusters) but also cells show a continuum of gene expression (trajectory). @urialonlab.bsky.social first used archetype analysis to reconcile this paradox - the bioinformatic equivalent of wave-particle duality. This works if the ambient data space is linear. 2/3
Not sure if this is what you meant. DOCK8 deficiency (but not STAT3) is reported to have peripheral blood ILC3 defect which corrects after HSCT. In contrast, SCID patients may not reconstitute their NKs and ILCs after HSCT with no obvious health consequences suggesting they are dispensable.
Evidence of innate lymphoid cell redundancy in humans - Nature Immunology
The importance of human innate lymphoid cells to normal human physiology is unclear. Vivier and colleagues find that immunodeficient patients ‘rescued’ with normal bone marrow can recover their T cell...
www.nature.com
May 3, 2025 at 3:18 PM
Not sure if this is what you meant. DOCK8 deficiency (but not STAT3) is reported to have peripheral blood ILC3 defect which corrects after HSCT. In contrast, SCID patients may not reconstitute their NKs and ILCs after HSCT with no obvious health consequences suggesting they are dispensable.
Thanks Mauro! They make beautiful memories!
April 30, 2025 at 2:17 PM
Thanks Mauro! They make beautiful memories!
So location does matter & boosting on the same side may make a difference! Basic research can underpin clinical translation. Can't have one without the other! Thankful to all our funders especially NHMRC, ACRF & UNSW Scientia Program. Thank you for reading please check out our paper! End 🧵
Macrophages direct location-dependent recall of B cell memory to vaccination
Vaccines generate long-lived plasma cells and memory B cells (Bmems) that may re-enter secondary germinal centers (GCs) to further mutate their B cell…
www.sciencedirect.com
April 29, 2025 at 1:20 PM
So location does matter & boosting on the same side may make a difference! Basic research can underpin clinical translation. Can't have one without the other! Thankful to all our funders especially NHMRC, ACRF & UNSW Scientia Program. Thank you for reading please check out our paper! End 🧵