4/4 By integrating:
✔️ Life cycle assessment (low-carbon substrates)
✔️ Techno-economic insights (from the start)
…we provide a path toward efficient, sustainable, scalable C1 biomanufacturing.

Great insight by @giusifav.bsky.social and @oscarpuiggene.bsky.social!

3/4 Our perspective lays out:
1️⃣ A blueprint for designing next-gen synthetic C1 microbes
2️⃣ A roadmap for engineering P. putida into an autotrophic chassis
3️⃣ A circular carbon economy vision, revalorizing CO₂ + waste streams
📊 Together, these steps connect design → engineering → sustainability.

2/4 Most work on synthetic C1 assimilation has focused on model microbes. But:
🧬 Non-canonical hosts bring untapped metabolic advantages
⚡ They tolerate diverse substrates & have unique enzymes
🌍 They could make C1-based processes more scalable & sustainable

The 5th edition of the #Pseudomonas grass roots meeting will take place on the 27th/28th of October 2025 in Denmark. This year, our group at DTU Biosustain will host 2 exciting days of networking, exchanging ideas and learning for early career-stage scientists working with Pseudomonas. 👇

Thanks to the organizers and everyone who made #ME16 unforgettable!

#SyntheticBiology #ME16 #Copenhagen

Back from an inspiring week at #ME16 in our home #Copenhagen! 🌍

Engaging talks, exciting science, and amazing connections — we’re full of new ideas!

🎉 Big congrats to @giusifav.bsky.social for winning a poster award 🏆
🙌 And proud to have our PI @pabnik.bsky.social as co-chair of the event!

2. Poor heterologous gene expression and stability for key enzymes -> 😤 Bring in deep learning + high-throughput screening. A match made in biotech heaven to customize your ideal catalysts. 3/n

1. C1-processing enzymes with low activity -> 🔧 Time to call in enzyme engineering strategies unlocking new functionalities, e.g., growth-coupled schemes. 2/n

..and fine tuning between endogenous activities and novel functions implemented by #metabolicengineering. A story - now available in preprint - brilliantly led by our Oscar! 💪