Kyle Jarrod McLean
@kylejarrodmclean.bsky.social
Malaria parasites, synthetic biology & tool development. @ MIT
Reposted by Kyle Jarrod McLean
Delighted to report our publication on a divergent cyclic nucleotide binding protein that regulates malaria transmission to mosquitoes. Great work by Domi Kwecka , @jennyregan.bsky.social @choel Kim #malaria #ookinete #mosquitoes #signalling journals.plos.org/plospathogen...
A divergent cyclic nucleotide binding protein promotes Plasmodium ookinete infection of the mosquito
Author summary Malaria parasites complete their life-cycle within mammalian and mosquito hosts requiring specialised forms to invade and establish infection in host tissue. In order to transmit to the...
journals.plos.org
September 16, 2025 at 9:33 AM
Delighted to report our publication on a divergent cyclic nucleotide binding protein that regulates malaria transmission to mosquitoes. Great work by Domi Kwecka , @jennyregan.bsky.social @choel Kim #malaria #ookinete #mosquitoes #signalling journals.plos.org/plospathogen...
Reposted by Kyle Jarrod McLean
In America, they have a Mason-Dixon Line. In Canada, it’s the Swiss Chalet-St-Hubert Line.
September 1, 2025 at 2:07 PM
In America, they have a Mason-Dixon Line. In Canada, it’s the Swiss Chalet-St-Hubert Line.
Reposted by Kyle Jarrod McLean
Our #CryoET story on how a top antimalarial drug candidate perturbs the native malarial translation machinery is out @natsmb.nature.com🥳 rdcu.be/eBbrH
A massive team effort led by @leonieanton.bsky.social Meseret Haile & Wenjing Cheng in collaboration with Jerzy Dziekan & the Alan Cowman! #TeamTomo
A massive team effort led by @leonieanton.bsky.social Meseret Haile & Wenjing Cheng in collaboration with Jerzy Dziekan & the Alan Cowman! #TeamTomo
Integrated structural biology of the native malarial translation machinery and its inhibition by an antimalarial drug
Nature Structural & Molecular Biology - Integrated structural biology approach leveraging in situ cryo-electron tomography reveals molecular details of the native malarial translation...
rdcu.be
August 18, 2025 at 12:13 PM
Our #CryoET story on how a top antimalarial drug candidate perturbs the native malarial translation machinery is out @natsmb.nature.com🥳 rdcu.be/eBbrH
A massive team effort led by @leonieanton.bsky.social Meseret Haile & Wenjing Cheng in collaboration with Jerzy Dziekan & the Alan Cowman! #TeamTomo
A massive team effort led by @leonieanton.bsky.social Meseret Haile & Wenjing Cheng in collaboration with Jerzy Dziekan & the Alan Cowman! #TeamTomo
Reposted by Kyle Jarrod McLean
Excited to share our latest collaborative work with @entomososwin.bsky.social @brackneylab.bsky.social looking at the role of mosquito immune cells in virus infection. It turns out that these cells help disseminate virus infection, increasing the potential for virus transmission rdcu.be/euiZt
Mosquito immune cells enhance dengue and Zika virus infection in Aedes aegypti
Nature Communications - Infection of mosquito immune cells by dengue and Zika virus enhances the spread of virus infection to mosquito tissues, such as the salivary glands, to promote virus...
rdcu.be
July 3, 2025 at 12:33 PM
Excited to share our latest collaborative work with @entomososwin.bsky.social @brackneylab.bsky.social looking at the role of mosquito immune cells in virus infection. It turns out that these cells help disseminate virus infection, increasing the potential for virus transmission rdcu.be/euiZt
Reposted by Kyle Jarrod McLean
🚨 New preprint alert! 🚨
We’ve uncovered a key player in malaria parasite cell division—meet PfAnchor, the first apicoplast-specific dynamin adaptor protein! Check the thread below 🧵for more details. #U_ExM #Malaria #Apicoplast
www.biorxiv.org/content/10.1...
We’ve uncovered a key player in malaria parasite cell division—meet PfAnchor, the first apicoplast-specific dynamin adaptor protein! Check the thread below 🧵for more details. #U_ExM #Malaria #Apicoplast
www.biorxiv.org/content/10.1...
An Essential Adaptor for Apicoplast Fission and Inheritance in Malaria Parasites
Blood-stage Plasmodium falciparum parasites rely on a non-photosynthetic plastid, the apicoplast, for survival, making it an attractive target for antimalarial intervention. Like the mitochondrion, th...
www.biorxiv.org
April 14, 2025 at 7:45 PM
🚨 New preprint alert! 🚨
We’ve uncovered a key player in malaria parasite cell division—meet PfAnchor, the first apicoplast-specific dynamin adaptor protein! Check the thread below 🧵for more details. #U_ExM #Malaria #Apicoplast
www.biorxiv.org/content/10.1...
We’ve uncovered a key player in malaria parasite cell division—meet PfAnchor, the first apicoplast-specific dynamin adaptor protein! Check the thread below 🧵for more details. #U_ExM #Malaria #Apicoplast
www.biorxiv.org/content/10.1...
Reposted by Kyle Jarrod McLean
They use the term "Entitlements" as a pejorative. It it not.
Things like Social Security are called Entitlements because... you're ENTITLED to them. You paid in. You're entitled to get paid out.
Tax breaks for billionaires are NOT entitlements.
Things like Social Security are called Entitlements because... you're ENTITLED to them. You paid in. You're entitled to get paid out.
Tax breaks for billionaires are NOT entitlements.
March 10, 2025 at 9:45 PM
They use the term "Entitlements" as a pejorative. It it not.
Things like Social Security are called Entitlements because... you're ENTITLED to them. You paid in. You're entitled to get paid out.
Tax breaks for billionaires are NOT entitlements.
Things like Social Security are called Entitlements because... you're ENTITLED to them. You paid in. You're entitled to get paid out.
Tax breaks for billionaires are NOT entitlements.
Reposted by Kyle Jarrod McLean
Excited to be able to share our new paper 'Iron Mediated Post-Transcriptional Regulation in Toxoplasma gondii'! Thanks to all involved including the awesome @clarehardinglab.bsky.social and @danaaghabi.bsky.social! journals.plos.org/plospathogen.... Read on for quick-read digest of our new work...
Iron-mediated post-transcriptional regulation in Toxoplasma gondii
Author summary Although iron is essential for most cells, excess can be toxic, so uptake and storage must be carefully controlled. The ability to respond to iron is particularly important for parasite...
journals.plos.org
February 5, 2025 at 11:50 AM
Excited to be able to share our new paper 'Iron Mediated Post-Transcriptional Regulation in Toxoplasma gondii'! Thanks to all involved including the awesome @clarehardinglab.bsky.social and @danaaghabi.bsky.social! journals.plos.org/plospathogen.... Read on for quick-read digest of our new work...
Reposted by Kyle Jarrod McLean
Yes, they can hallucinate papers that don't exist, discuss results that seem to be imaginary, and can be confusing and inconsistent. But talking to tenured professors may still be helpful
January 14, 2025 at 10:30 PM
Yes, they can hallucinate papers that don't exist, discuss results that seem to be imaginary, and can be confusing and inconsistent. But talking to tenured professors may still be helpful
Reposted by Kyle Jarrod McLean
There is no justification for a higher bar of fees/taxes/anti-gentrification policy for apartments. Low density is the most gentrifying build environment in a city, lived in by the richest. Higher density is what lower income and less wealthy people live in.
January 14, 2025 at 9:54 PM
There is no justification for a higher bar of fees/taxes/anti-gentrification policy for apartments. Low density is the most gentrifying build environment in a city, lived in by the richest. Higher density is what lower income and less wealthy people live in.
Reposted by Kyle Jarrod McLean
I just read another paper that didn’t deposit their plasmid sequences anywhere. It doesn’t have to be Addgene, but gbk file on Zenodo would be good. I literally have no way to find out the exact modifications to the constructs from the text. Journals shouldn’t allow this.
May 24, 2024 at 3:34 AM
I just read another paper that didn’t deposit their plasmid sequences anywhere. It doesn’t have to be Addgene, but gbk file on Zenodo would be good. I literally have no way to find out the exact modifications to the constructs from the text. Journals shouldn’t allow this.
Reposted by Kyle Jarrod McLean
🌍" #Malaria Is Surging in #Ethiopia🇪🇹, Reversing Decade of Progress Against the Disease.
#ClimateChange, civil conflict and growing #resistance to insecticides & treatments [+spread of An. stephensi🦟] are all contributing to alarming spread of cases." @nytimes.com
www.nytimes.com/2024/10/25/h...
#ClimateChange, civil conflict and growing #resistance to insecticides & treatments [+spread of An. stephensi🦟] are all contributing to alarming spread of cases." @nytimes.com
www.nytimes.com/2024/10/25/h...
Malaria Is Surging in Ethiopia, Reversing a Decade of Progress Against the Disease
Climate change, civil conflict and growing resistance to insecticides and treatments are all contributing to an alarming spread of cases.
www.nytimes.com
October 25, 2024 at 11:14 AM
🌍" #Malaria Is Surging in #Ethiopia🇪🇹, Reversing Decade of Progress Against the Disease.
#ClimateChange, civil conflict and growing #resistance to insecticides & treatments [+spread of An. stephensi🦟] are all contributing to alarming spread of cases." @nytimes.com
www.nytimes.com/2024/10/25/h...
#ClimateChange, civil conflict and growing #resistance to insecticides & treatments [+spread of An. stephensi🦟] are all contributing to alarming spread of cases." @nytimes.com
www.nytimes.com/2024/10/25/h...
Reposted by Kyle Jarrod McLean
New version of this paper just hit @biorxivpreprint! New collaborator co-authors, and their very interesting new data on vertebrate DNA detection in wild-caught male mosquitoes! Perhaps this is not just a crazy lab phenomenon after all!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
October 25, 2024 at 11:33 AM
New version of this paper just hit @biorxivpreprint! New collaborator co-authors, and their very interesting new data on vertebrate DNA detection in wild-caught male mosquitoes! Perhaps this is not just a crazy lab phenomenon after all!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...