Kalyani Bambal
@kriyer.bsky.social
Pathologist.Interests in
#surgicalpath #breastpath #bstpath #gupath #oncopath
#surgicalpath #breastpath #bstpath #gupath #oncopath
Reposted by Kalyani Bambal
Reposted by Kalyani Bambal
This is classic morphology for a GLI1 coamplified differentiated liposarcoma with perineurial-like whorls. So now the MDM2 amplification makes sense. The current tumor is showing essentially classical features of a GLI1 amplified soft tissue sarcoma. So the morphology/molecular explain each other.
June 12, 2025 at 9:10 PM
This is classic morphology for a GLI1 coamplified differentiated liposarcoma with perineurial-like whorls. So now the MDM2 amplification makes sense. The current tumor is showing essentially classical features of a GLI1 amplified soft tissue sarcoma. So the morphology/molecular explain each other.
Reposted by Kalyani Bambal
STAT6 Can Be Used in the Diagnosis of Hodgkin Lymphoma; There Are Differences in Expression Among Subtypes journals.lww.com/appliedimmun...
STAT6 Can Be Used in the Diagnosis of Hodgkin Lymphoma;... : Applied Immunohistochemistry & Molecular Morphology
the STAT6 (EP325) immunostain, diagnosing Hodgkin lymphoma, its staining frequency, immunolocalization, and its relationship with EBV. Sixty-eight patients representing each Hodgkin lymphoma subtype w...
journals.lww.com
August 5, 2025 at 12:09 AM
STAT6 Can Be Used in the Diagnosis of Hodgkin Lymphoma; There Are Differences in Expression Among Subtypes journals.lww.com/appliedimmun...
Reposted by Kalyani Bambal
Distinct levels of DDIT3 Amplification in Dedifferentiated Liposarcoma Developing After DDIT3 Rearrangement in Myxoid Liposarcoma journals.lww.com/appliedimmun...
Distinct levels of DDIT3 Amplification in Dedifferentiated... : Applied Immunohistochemistry & Molecular Morphology
diagnostic tool for accurate diagnosis. While DDIT3 rearrangement is a known characteristic of myxoid LPS, its amplification in DDLPS has not been extensively studied. To investigate this, we evaluate...
journals.lww.com
August 5, 2025 at 12:09 AM
Distinct levels of DDIT3 Amplification in Dedifferentiated Liposarcoma Developing After DDIT3 Rearrangement in Myxoid Liposarcoma journals.lww.com/appliedimmun...
Reposted by Kalyani Bambal
Investigating Biomarkers in Primary Tumors and Lymph Node Metastases in Tongue Squamous Cell Carcinoma: An Immunohistochemical Perspective journals.lww.com/appliedimmun...
Investigating Biomarkers in Primary Tumors and Lymph Node... : Applied Immunohistochemistry & Molecular Morphology
tases. A total of 60 TSCC biopsy samples, 20 primary metastatic, 20 lymph node metastatic, and 20 nonmetastatic, were immunohistochemically stained to analyze MCM2, CD44, and E-cadherin expression. Ex...
journals.lww.com
August 5, 2025 at 10:43 AM
Investigating Biomarkers in Primary Tumors and Lymph Node Metastases in Tongue Squamous Cell Carcinoma: An Immunohistochemical Perspective journals.lww.com/appliedimmun...
Reposted by Kalyani Bambal
Nasopharyngeal mass, adult male.
Dx: Hyalinizing clear cell ca.
➡️Nests of eosinophilic and/or clear cells. Helpful: 2 ‘types’ of fibrosis (dense hyalinization and fibrolamellar stromal fibrosis).
#PathSky #ENTsky #HeadNeckSky
Dx: Hyalinizing clear cell ca.
➡️Nests of eosinophilic and/or clear cells. Helpful: 2 ‘types’ of fibrosis (dense hyalinization and fibrolamellar stromal fibrosis).
#PathSky #ENTsky #HeadNeckSky
August 19, 2025 at 10:04 PM
Nasopharyngeal mass, adult male.
Dx: Hyalinizing clear cell ca.
➡️Nests of eosinophilic and/or clear cells. Helpful: 2 ‘types’ of fibrosis (dense hyalinization and fibrolamellar stromal fibrosis).
#PathSky #ENTsky #HeadNeckSky
Dx: Hyalinizing clear cell ca.
➡️Nests of eosinophilic and/or clear cells. Helpful: 2 ‘types’ of fibrosis (dense hyalinization and fibrolamellar stromal fibrosis).
#PathSky #ENTsky #HeadNeckSky
Reposted by Kalyani Bambal
Tracheal adenoid cystic carcinoma. At high magnification (next 2 pics), areas of ‘signet-ring like’ or vacuolated, clear cell change is noted in ducts. Unknown clinical significance but when present in small biopsy material, may lead to diagnostic uncertainty.
PMID: 23379326
PMID: 39235305 (fig 3)
PMID: 23379326
PMID: 39235305 (fig 3)
August 4, 2025 at 12:59 PM
Tracheal adenoid cystic carcinoma. At high magnification (next 2 pics), areas of ‘signet-ring like’ or vacuolated, clear cell change is noted in ducts. Unknown clinical significance but when present in small biopsy material, may lead to diagnostic uncertainty.
PMID: 23379326
PMID: 39235305 (fig 3)
PMID: 23379326
PMID: 39235305 (fig 3)
Reposted by Kalyani Bambal
Image of the Week!
Submitted by: Halida Hakic Beslagic, M.D.
Directory Profile: buff.ly/ys2Oh0O
Subspecialty: GI / liver
Diagnosis: FNA Liver - adenocarcinoma
#Pathology #PathologyOutlines #PathSky
Submitted by: Halida Hakic Beslagic, M.D.
Directory Profile: buff.ly/ys2Oh0O
Subspecialty: GI / liver
Diagnosis: FNA Liver - adenocarcinoma
#Pathology #PathologyOutlines #PathSky
June 4, 2025 at 2:06 PM
Image of the Week!
Submitted by: Halida Hakic Beslagic, M.D.
Directory Profile: buff.ly/ys2Oh0O
Subspecialty: GI / liver
Diagnosis: FNA Liver - adenocarcinoma
#Pathology #PathologyOutlines #PathSky
Submitted by: Halida Hakic Beslagic, M.D.
Directory Profile: buff.ly/ys2Oh0O
Subspecialty: GI / liver
Diagnosis: FNA Liver - adenocarcinoma
#Pathology #PathologyOutlines #PathSky
Reposted by Kalyani Bambal
Just published! Check out this latest article 👉🏻 HER2 amplification is rare (1.7%) in low-grade, tubule-forming breast cancers with 2+ HER2 IHC; findings suggest ISH may be unnecessary in this subset #breastpath #IHCpath #pathsky
The Value of Routine Reflex In Situ Hybridization Testing in Low-grade Tubule-forming Invasive Breast Cancers With Equivocal HER2 Immunohistochemistry - A Reappraisal of the ASCO/CAP Guidelines journals.lww.com/appliedimmun...
The Value of Routine Reflex In Situ Hybridization Testing... : Applied Immunohistochemistry & Molecular Morphology
emistry (IHC). While this recommendation mainly addresses aggressive tumor types such as micropapillary carcinoma, it is applied to low-grade, tubule-forming IBCs unlikely to show HER2 amplification. ...
journals.lww.com
May 29, 2025 at 12:44 AM
Just published! Check out this latest article 👉🏻 HER2 amplification is rare (1.7%) in low-grade, tubule-forming breast cancers with 2+ HER2 IHC; findings suggest ISH may be unnecessary in this subset #breastpath #IHCpath #pathsky
Reposted by Kalyani Bambal
#PathSky Middle aged woman, leg mass. It all looks like this. More nuclear palisading/ Verocay bodies than you’ve seen in your entire career. Nerve sheath? S100/Sox10 negative. LMS? Negative for all the muscle markers. Any other ideas?
May 20, 2025 at 9:30 PM
#PathSky Middle aged woman, leg mass. It all looks like this. More nuclear palisading/ Verocay bodies than you’ve seen in your entire career. Nerve sheath? S100/Sox10 negative. LMS? Negative for all the muscle markers. Any other ideas?
Reposted by Kalyani Bambal
So- desmoid fibromatosis with bizarre cells and p53 mutant pattern- r/o Li-Fraumeni syndrome.
Happy Friday!
pubmed.ncbi.nlm.nih.gov/36908221/
Happy Friday!
pubmed.ncbi.nlm.nih.gov/36908221/
Desmoid Fibromatosis With TP53 Mutation and Striking Nuclear Pleomorphism - PubMed
Desmoid fibromatosis is a myofibroblastic neoplasm of intermediate biologic potential, which has a strong predilection for local recurrence but does not metastasize. Arranged in long, sweeping fascicl...
pubmed.ncbi.nlm.nih.gov
May 30, 2025 at 5:38 PM
So- desmoid fibromatosis with bizarre cells and p53 mutant pattern- r/o Li-Fraumeni syndrome.
Happy Friday!
pubmed.ncbi.nlm.nih.gov/36908221/
Happy Friday!
pubmed.ncbi.nlm.nih.gov/36908221/
Reposted by Kalyani Bambal
#PathSky Abdominal wall mass, middle aged woman. Women basically only get 3 abdominal wall tumors, so it’s got to be a desmoid, DFSP or endometriosis. Classic desmoid morphology, aberrant nuclear beta-catenin. I can hear the cries of “boring..”
May 30, 2025 at 5:31 PM
#PathSky Abdominal wall mass, middle aged woman. Women basically only get 3 abdominal wall tumors, so it’s got to be a desmoid, DFSP or endometriosis. Classic desmoid morphology, aberrant nuclear beta-catenin. I can hear the cries of “boring..”
Reposted by Kalyani Bambal
This of course is what we now call “myxoinflammatory fibroblastic sarcoma”. Originally reported as “Inflammatory myxohyaline tumor of distal extremities with virocyte or Reed-Sternberg-like cells”. I think this older name helps us remember the distinctive diagnostic features of this sarcoma.
April 29, 2025 at 6:46 PM
This of course is what we now call “myxoinflammatory fibroblastic sarcoma”. Originally reported as “Inflammatory myxohyaline tumor of distal extremities with virocyte or Reed-Sternberg-like cells”. I think this older name helps us remember the distinctive diagnostic features of this sarcoma.
Reposted by Kalyani Bambal
#PathSky 43M, forearm mass. At first glance, it looks like some kind of inflammatory process, maybe a synovitis with plasma cells, fibrosis and foamy macrophages.
April 29, 2025 at 6:38 PM
#PathSky 43M, forearm mass. At first glance, it looks like some kind of inflammatory process, maybe a synovitis with plasma cells, fibrosis and foamy macrophages.
Reposted by Kalyani Bambal
Degenerating vegetable. Likely a ruptured diverticulitis with a big reactive soft tissue mass. Happy Friday!!
May 2, 2025 at 6:25 PM
Degenerating vegetable. Likely a ruptured diverticulitis with a big reactive soft tissue mass. Happy Friday!!
Reposted by Kalyani Bambal
Those of you following my cases know the answer is usually “look at the slides some more”.
May 2, 2025 at 6:24 PM
Those of you following my cases know the answer is usually “look at the slides some more”.
Reposted by Kalyani Bambal
#PathSky 45 with a forearm skin tumor. Highly cellular, monomorphic spindle cell tumor with a “packeted” pattern and deep, nodular lymphoid aggregates.
May 8, 2025 at 4:36 PM
#PathSky 45 with a forearm skin tumor. Highly cellular, monomorphic spindle cell tumor with a “packeted” pattern and deep, nodular lymphoid aggregates.
Reposted by Kalyani Bambal
Check out our Current Issue!!
Figure from "Claudin 18.2 Immunohistochemistry Expression in Gastric Cancer: A Systematic Review” by Lop Gros, et al.
🔗 Read the full article here: journals.lww.com/appliedimmun...
Figure from "Claudin 18.2 Immunohistochemistry Expression in Gastric Cancer: A Systematic Review” by Lop Gros, et al.
🔗 Read the full article here: journals.lww.com/appliedimmun...
March 5, 2025 at 11:58 PM
Check out our Current Issue!!
Figure from "Claudin 18.2 Immunohistochemistry Expression in Gastric Cancer: A Systematic Review” by Lop Gros, et al.
🔗 Read the full article here: journals.lww.com/appliedimmun...
Figure from "Claudin 18.2 Immunohistochemistry Expression in Gastric Cancer: A Systematic Review” by Lop Gros, et al.
🔗 Read the full article here: journals.lww.com/appliedimmun...
Reposted by Kalyani Bambal
Reposted by Kalyani Bambal
Vaccines don’t cause autism.
Vaccine ingredients don’t cause autism. Vaccines don’t worsen autism symptoms.
Millions of data points over decades show this.
A paper published in a “journal” that funded the “study” doesn’t supersede reality.
Stop spreading lies that harm people.
1/
Vaccine ingredients don’t cause autism. Vaccines don’t worsen autism symptoms.
Millions of data points over decades show this.
A paper published in a “journal” that funded the “study” doesn’t supersede reality.
Stop spreading lies that harm people.
1/
January 27, 2025 at 3:09 AM
Vaccines don’t cause autism.
Vaccine ingredients don’t cause autism. Vaccines don’t worsen autism symptoms.
Millions of data points over decades show this.
A paper published in a “journal” that funded the “study” doesn’t supersede reality.
Stop spreading lies that harm people.
1/
Vaccine ingredients don’t cause autism. Vaccines don’t worsen autism symptoms.
Millions of data points over decades show this.
A paper published in a “journal” that funded the “study” doesn’t supersede reality.
Stop spreading lies that harm people.
1/
Reposted by Kalyani Bambal
www.sciencedirect.com/science/arti...
Link to the paper that should help everyone diagnose keratoacanthoma with greater confidence.
Link to the paper that should help everyone diagnose keratoacanthoma with greater confidence.
January 14, 2025 at 8:35 AM
www.sciencedirect.com/science/arti...
Link to the paper that should help everyone diagnose keratoacanthoma with greater confidence.
Link to the paper that should help everyone diagnose keratoacanthoma with greater confidence.
Reposted by Kalyani Bambal
We eventually figured out that this was a new entity, “xanthogranulomatous epithelial tumor”. Locally aggressive, non-metastasizing. They turn out to have unique HMGA2::NCOR fusions. “Keratin-positive giant cell tumor of bone” is the same thing. pubmed.ncbi.nlm.nih.gov/38278607/
Xanthogranulomatous Epithelial Tumors and Keratin-Positive Giant Cell Rich Tumors of Soft Tissue and Bone: Two Sides of the Same Coin - PubMed
Xanthogranulomatous epithelial tumor is a recently described soft tissue tumor characterized by subcutaneous location, partial encapsulation, a xanthogranulomatous inflammatory cell infiltrate, and ke...
pubmed.ncbi.nlm.nih.gov
December 26, 2024 at 7:06 PM
We eventually figured out that this was a new entity, “xanthogranulomatous epithelial tumor”. Locally aggressive, non-metastasizing. They turn out to have unique HMGA2::NCOR fusions. “Keratin-positive giant cell tumor of bone” is the same thing. pubmed.ncbi.nlm.nih.gov/38278607/