Josh Koenig
@koenigjfe.bsky.social
Reposted by Josh Koenig
It was wonderful to share the lab’s work with colleagues at McMaster University and their Immunology Research Center. Thanks, Amy and Josh, and lovely to meet colleagues at my Alma mater. #LZCI
March 6, 2025 at 12:46 PM
It was wonderful to share the lab’s work with colleagues at McMaster University and their Immunology Research Center. Thanks, Amy and Josh, and lovely to meet colleagues at my Alma mater. #LZCI
Reposted by Josh Koenig
Microbial metabolism of food allergens determines the severity of IgE-mediated anaphylaxis https://www.biorxiv.org/content/10.1101/2025.02.17.638013v1
February 19, 2025 at 10:17 AM
Microbial metabolism of food allergens determines the severity of IgE-mediated anaphylaxis https://www.biorxiv.org/content/10.1101/2025.02.17.638013v1
What a great thing to wake up to! Thank you CIHR for the support for the lab to dive into the mechanisms of immune memory in allergy!
January 29, 2025 at 1:21 PM
What a great thing to wake up to! Thank you CIHR for the support for the lab to dive into the mechanisms of immune memory in allergy!
Reposted by Josh Koenig
Check out the latest publication by @khoulahan.bsky.social!
The Curtis Lab’s latest study on the genomic architecture of breast cancer from the pre-invasive to metastatic setting is now out in Nature! www.nature.com/articles/s41...
Complex rearrangements fuel ER+ and HER2+ breast tumours - Nature
A study identifies three dominant genomic archetypes of breast cancer induced by discrete mutational processes, describing a continuum of genomic profiles and detailing the mechanisms underlying the p...
www.nature.com
January 9, 2025 at 3:20 PM
Check out the latest publication by @khoulahan.bsky.social!
Reposted by Josh Koenig
Pleased to share our work looking at the evolutionary relationship between mutability, somatic hypermutation and codon optimality in human immunoglobulin genes and V(D)J repertoires. Such a fun project – check it out, online now at Molecular Cell! @cellpress.bsky.social
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Mutability and hypermutation antagonize immunoglobulin codon optimality
McGrath et al. investigate the evolutionary relationship between V(D)J mutability, somatic hypermutation, and codon optimality within immunoglobulin repertoires in order to gain a better understanding of how diversification mechanisms might impact antibody expression efficiency.
www.cell.com
December 30, 2024 at 3:35 PM
Pleased to share our work looking at the evolutionary relationship between mutability, somatic hypermutation and codon optimality in human immunoglobulin genes and V(D)J repertoires. Such a fun project – check it out, online now at Molecular Cell! @cellpress.bsky.social
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Reposted by Josh Koenig
would be curious about #hemesky's input here- any concern about inducing hypercoagulability through vaccine adjuvantation with thrombopoeitin (TPO)?
Awesome study that also highlights species-specific differences in immunity (e.g. plasma cell APRIL dependence) and the consistency across...
Awesome study that also highlights species-specific differences in immunity (e.g. plasma cell APRIL dependence) and the consistency across...
System vaccinology analysis of predictors and mechanisms of antibody response durability to multiple vaccines in humans
#Pulendran Hagan
@cincyresearch.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41... commentary by @petterbrodin.bsky.social
#Pulendran Hagan
@cincyresearch.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41... commentary by @petterbrodin.bsky.social
January 2, 2025 at 11:39 PM
would be curious about #hemesky's input here- any concern about inducing hypercoagulability through vaccine adjuvantation with thrombopoeitin (TPO)?
Awesome study that also highlights species-specific differences in immunity (e.g. plasma cell APRIL dependence) and the consistency across...
Awesome study that also highlights species-specific differences in immunity (e.g. plasma cell APRIL dependence) and the consistency across...
Reposted by Josh Koenig
Really interesting study on the mutability and codon optimality of human IgV genes, showing an inverse relation. Mutability appears to trump codon optimality for immunoglobulin genes! www.sciencedirect.com/science/arti... 🩸🔬 #b-cells #immunology
Mutability and hypermutation antagonize immunoglobulin codon optimality
The efficacy of antibody responses is inherently linked to paratope diversity, as generated through V(D)J recombination and somatic hypermutation. Des…
www.sciencedirect.com
December 29, 2024 at 4:52 PM
Really interesting study on the mutability and codon optimality of human IgV genes, showing an inverse relation. Mutability appears to trump codon optimality for immunoglobulin genes! www.sciencedirect.com/science/arti... 🩸🔬 #b-cells #immunology
Reposted by Josh Koenig
So proud @theonlylabever.bsky.social who persevered with this impactful project. First author Dr. Kyle Burrows is now lunching his own lab at SFU. Nicely done!
A gut commensal protozoan determines respiratory disease outcomes by shaping pulmonary immunity
The gut protist Tritrichomonas musculis induces migration of innate lymphoid cells and eosinophils to shape immune responses in the lungs of mice and humans.
www.cell.com
December 20, 2024 at 1:04 PM
So proud @theonlylabever.bsky.social who persevered with this impactful project. First author Dr. Kyle Burrows is now lunching his own lab at SFU. Nicely done!
Reposted by Josh Koenig
#LocationLocationLocation! Burrows, Mortha &co show @cellcellpress.bsky.social that a gut commensal protozoan induces ILC2 migration from the gut to the lung & interaction with T & B cells, recruiting lung eosinophils that shield the vasculature aggravating #asthma but protecting from #Mycobacterium
Redirecting
doi.org
December 19, 2024 at 6:45 PM
#LocationLocationLocation! Burrows, Mortha &co show @cellcellpress.bsky.social that a gut commensal protozoan induces ILC2 migration from the gut to the lung & interaction with T & B cells, recruiting lung eosinophils that shield the vasculature aggravating #asthma but protecting from #Mycobacterium
Reposted by Josh Koenig
Amazing new paper providing the architecture of the high-affinity IgE receptor in a IgE-sensitized state and the apo state. Also revealing that mice and men are different...
#Immunosky #Immunology
www.science.org/doi/epdf/10....
#Immunosky #Immunology
www.science.org/doi/epdf/10....
Architecture of the high-affinity immunoglobulin E receptor
Structural analysis reveals species-specific differences in how the antibody IgE binds to its receptor FcεRI.
www.science.org
December 16, 2024 at 10:46 AM
Amazing new paper providing the architecture of the high-affinity IgE receptor in a IgE-sensitized state and the apo state. Also revealing that mice and men are different...
#Immunosky #Immunology
www.science.org/doi/epdf/10....
#Immunosky #Immunology
www.science.org/doi/epdf/10....
Reposted by Josh Koenig
B CELL FUN FACT: Secrets of the GC #2
There are 300 billion B cells with total mass of 60g in the human body. That is 3 times the number of stars in the Milky Way! Naïve B cell express >10 million unique antibodies to protect us from this universe of possible antigens!
www.pnas.org/doi/10.1073/...
There are 300 billion B cells with total mass of 60g in the human body. That is 3 times the number of stars in the Milky Way! Naïve B cell express >10 million unique antibodies to protect us from this universe of possible antigens!
www.pnas.org/doi/10.1073/...
The total mass, number, and distribution of immune cells in the human body | PNAS
The immune system is a complex network of cells with critical functions in health
and disease. However, a comprehensive census of the cells compris...
www.pnas.org
December 9, 2024 at 11:22 AM
B CELL FUN FACT: Secrets of the GC #2
There are 300 billion B cells with total mass of 60g in the human body. That is 3 times the number of stars in the Milky Way! Naïve B cell express >10 million unique antibodies to protect us from this universe of possible antigens!
www.pnas.org/doi/10.1073/...
There are 300 billion B cells with total mass of 60g in the human body. That is 3 times the number of stars in the Milky Way! Naïve B cell express >10 million unique antibodies to protect us from this universe of possible antigens!
www.pnas.org/doi/10.1073/...
Reposted by Josh Koenig
Very excited to share the most recent work from #theonlylabever out in @jexpmed.bsky.social
We show that a gut protozoan commensal acts as a natural adjuvant for IgA against oral and bacterial antigens to strengthen homeostasis.
Hope you will find this interesting:
doi.org/10.1084/jem....
We show that a gut protozoan commensal acts as a natural adjuvant for IgA against oral and bacterial antigens to strengthen homeostasis.
Hope you will find this interesting:
doi.org/10.1084/jem....
The protozoan commensal Tritrichomonas musculis is a natural adjuvant for mucosal IgA | Journal of Experimental Medicine | Rockefeller University Press
The gut commensal protist Tritrichomonas musculis (T.mu) boosts T cell–dependent IgA. T.mu-driven IgA modifies the commensal bacterial microbiota and impro
doi.org
November 18, 2024 at 4:53 AM
Very excited to share the most recent work from #theonlylabever out in @jexpmed.bsky.social
We show that a gut protozoan commensal acts as a natural adjuvant for IgA against oral and bacterial antigens to strengthen homeostasis.
Hope you will find this interesting:
doi.org/10.1084/jem....
We show that a gut protozoan commensal acts as a natural adjuvant for IgA against oral and bacterial antigens to strengthen homeostasis.
Hope you will find this interesting:
doi.org/10.1084/jem....
Reposted by Josh Koenig
🎨 In case anyone need…
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
November 23, 2024 at 3:50 PM
🎨 In case anyone need…
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
Reposted by Josh Koenig
Save the date! It may be a while to go yet, but I’m very excited for our B-cellapalooza in 2026!
November 16, 2024 at 10:47 AM
Save the date! It may be a while to go yet, but I’m very excited for our B-cellapalooza in 2026!
Reposted by Josh Koenig
Thanks to Josh Koenig, Allyssa Phelps, & Diego Pazos-Castro for taking the lead and writing up the protocol below initially developed during the early days of my postdoc. Discussed in this go.nature.com/3OxA5yD “behind the paper” post. www.nature.com/articles/s41...
Production and use of antigen tetramers to study antigen-specific B cells - Nature Protocols
Antigen-specific B cells constitute a small proportion of the total B cell population, making identification for downstream analysis challenging. Here, this is achieved by pairing fluorescent antigen ...
www.nature.com
February 26, 2024 at 5:43 PM
Thanks to Josh Koenig, Allyssa Phelps, & Diego Pazos-Castro for taking the lead and writing up the protocol below initially developed during the early days of my postdoc. Discussed in this go.nature.com/3OxA5yD “behind the paper” post. www.nature.com/articles/s41...