Koeberle Lab
koeberlelab.bsky.social
Koeberle Lab
@koeberlelab.bsky.social
Lipid Signaling • (Redox)lipidomics • Inflammation • Cancer • Ferroptosis • Natural Products • Mode of Action • Drug Design & Discovery • Phytochemical Biology
Excited to share our latest publication in which we uncover a link between ether phospholipid degradation and lipid mediator biosynthesis! This collaboration with the Katrin Watschinger lab provides new insights on sex-dependent lipid metabolism and signaling.

rdcu.be/epE1w
June 7, 2025 at 11:43 AM
Reposted by Koeberle Lab
Thrilled this paper is out! We solved the first cocrystal structure of FSP1 with an inhibitor (FSEN1), providing mechanistic insight & a foundation for medchem. Led by Amalia Megarioti & Sitao Zhang. A terrific collaboration with Da Jia.
Brief Skytorial!
1/9
Cocrystal structure reveals the mechanism of FSP1 inhibition by FSEN1 | PNAS
FSP1 is an FAD-dependent oxidoreductase that uses NAD(P)H to regenerate the reduced forms of lipophilic quinone antioxidants, such as coenzyme Q10 ...
www.pnas.org
May 29, 2025 at 6:02 PM
Reposted by Koeberle Lab
Online now - the Review "The metabolic code of #ferroptosis: nutritional regulators of cell death" from @angelifriedmann.bsky.social @k-hadian.bsky.social and colleagues.

#LipidPeroxidation #Nutrients #Metabolites #Vitamins #Lipids

Read it here 👉 authors.elsevier.com/sd/article/S...
May 29, 2025 at 2:21 PM
Reposted by Koeberle Lab
Humbled to receive the 2025 Beatriz Manz Award from UC Berkeley. Thank you for this honor! 🙏 ☺️
ls.berkeley.edu/news/uc-berk...
UC Berkeley Letters & Science announces recipients of 2025 L&S Faculty Awards | Letters & Science
ls.berkeley.edu
April 12, 2025 at 6:38 AM
Reposted by Koeberle Lab
📢 Only one more week to apply!
We are looking for a PhD candidate in molecular biology / biochemistry / chemical biology with a passion for drug discovery to join our young and enthusiastic team @univie.ac.at. For details, visit: vds-phanuspo.univie.ac.at/application/.... Reposts are very much appreciated!
April 7, 2025 at 10:26 AM
Reposted by Koeberle Lab
Groundbreaking study in Cell from @leventallab.bsky.social: phospholipid asymmetry is a defining feature of the plasma membrane and cholesterol fills the holes — major implications for how this membrane works. A #lipidtime must-read! www.cell.com/cell/abstrac...
Cell membranes sustain phospholipid imbalance via cholesterol asymmetry
This work challenges a major assumption in cell biology by showing that lipid bilayers can have drastically different phospholipid abundances between their two leaflets. This lipid abundance asymmetry...
www.cell.com
April 3, 2025 at 3:07 PM
Reposted by Koeberle Lab
We are looking for a PhD candidate in molecular biology / biochemistry / chemical biology with a passion for drug discovery to join our young and enthusiastic team @univie.ac.at. For details, visit: vds-phanuspo.univie.ac.at/application/.... Reposts are very much appreciated!
March 21, 2025 at 2:51 PM
Reposted by Koeberle Lab
🧫 Ein internationales Forschungsteam rund um Andreas Koeberle hat einen Mechanismus entdeckt, der neue Behandlungsstrategien für Tumore eröffnet, bei denen konventionelle Chemotherapeutika an ihre Grenzen stoßen:
🔗 www.uni-graz.at/de/neuigkeit...

#weworkfortomorrow
February 25, 2025 at 11:40 AM
Reposted by Koeberle Lab
💊 Dem Leberfett zu Leibe gerückt: Die Uni-Graz-Pharmakognostin Solveigh Koeberle forscht an neuen Medikamenten für degenerative Erkrankungen. www.uni-graz.at/de/neuigkeit...
February 28, 2025 at 9:07 AM
Curious about the interplay between #apoptosis and #ferroptosis and their role in cytotoxic stress, whether induced by drugs or serum depletion? Check out our latest paper in #NatureCommunications.

rdcu.be/ebbYX

@unigraz #CellDeath #LipidMetabolism
February 25, 2025 at 11:40 AM
Reposted by Koeberle Lab
Registration is open for our summer FASEB #Ferroptosis Conference July 27 - 31, 2025. We have a terrific line up of speakers and it's going to be amazzzing! Come join us for this historic first meeting! Please help us to spread the word. 🤩
shorturl.at/QA6T1
February 13, 2025 at 6:27 AM
Reposted by Koeberle Lab
Happy to share our work on the mechanism of glycolysis in cancer now published in the journal Nature Metabolism. This was a large part of my postdoctoral work carried out in the lab of Prof. @almutschulze.bsky.social at the @dkfz.bsky.social and at Uni Wuerzburg.

www.nature.com/articles/s42...
Targeting aldolase A in hepatocellular carcinoma leads to imbalanced glycolysis and energy stress due to uncontrolled FBP accumulation - Nature Metabolism
Snaebjornsson et al. explore a selective vulnerability in cancer elicited by targeting aldolase A, which causes energy imbalance and prevents further metabolic adaptations.
www.nature.com
January 22, 2025 at 8:31 AM
Reposted by Koeberle Lab
Excited to announce two DFG-funded PhD positions to study Lipid Droplet Heterogeneity in cancer as part of FOR5815. Join us @dkfz-heidelberg if you are interested in #cancermetabolism and #lipidbiology

jobs.dkfz.de/en/jobs/1673...

jobs.dkfz.de/de/jobs/1673...
PhD Student in Lipid Metabolism in Cancer
jobs.dkfz.de
December 20, 2024 at 10:04 AM
Reposted by Koeberle Lab
Looking for exciting opportunities? 🎓 Apply for PhD positions in my lab and others in this fantastic program! 🚀
If you're seeking a postdoc or senior lab scientist role, feel free to DM or email me. Let's connect!
@imprs-cbp.bsky.social #PhDPositions #PostdocJobs
December 9, 2024 at 10:55 PM
Reposted by Koeberle Lab
Published in the current edition of #MolCell ours and Marcus Conrad group study made the cover 🤩

Different biology converging on the newly identified role of #Prdx6 acting as a selenium carrier protein

🌕🌖🌗🌘🌑🌒🌓🌔🌕
December 5, 2024 at 7:54 PM