Laura
@kilarski.bsky.social
Resident doctor in psychiatry and postdoc with an interest in complex disease genetics, pharmacogenetics, long COVID and way too many other things at University Hospital Bonn, Germany. Also wife to a Plastic Paddy and mum to a 8yo boy who melts my heart.
RIP Jane Goodall.. www.nytimes.com/2025/10/01/s...
Jane Goodall: A Life in Pictures
www.nytimes.com
October 2, 2025 at 6:09 AM
RIP Jane Goodall.. www.nytimes.com/2025/10/01/s...
Reposted by Laura
☀️ We are happy to have Jente Meijer from the Bonn–Melbourne Joint PhD Program visiting us in Bonn this week! ☀️
Her talk “Towards precision psychiatry using multi-view clustering approaches” was a wonderful opportunity to learn how machine learning can be applied in psychiatry. 🎓🧠💻
Her talk “Towards precision psychiatry using multi-view clustering approaches” was a wonderful opportunity to learn how machine learning can be applied in psychiatry. 🎓🧠💻
September 24, 2025 at 12:23 PM
☀️ We are happy to have Jente Meijer from the Bonn–Melbourne Joint PhD Program visiting us in Bonn this week! ☀️
Her talk “Towards precision psychiatry using multi-view clustering approaches” was a wonderful opportunity to learn how machine learning can be applied in psychiatry. 🎓🧠💻
Her talk “Towards precision psychiatry using multi-view clustering approaches” was a wonderful opportunity to learn how machine learning can be applied in psychiatry. 🎓🧠💻
Stop the CDU demanding information from NGOs that impinge on their freedom of speech, including the freedom to attend anti-right demos despite govermental funding - please sign the petition: weact.campact.de/petitions/sc...
weact.campact.de
February 26, 2025 at 4:59 PM
Stop the CDU demanding information from NGOs that impinge on their freedom of speech, including the freedom to attend anti-right demos despite govermental funding - please sign the petition: weact.campact.de/petitions/sc...
Interesting new preprint:
Polygenic contributions to lithium augmentation outcomes in antidepressant non-responders with unipolar depression: www.medrxiv.org/content/10.1...
Polygenic contributions to lithium augmentation outcomes in antidepressant non-responders with unipolar depression: www.medrxiv.org/content/10.1...
January 26, 2025 at 5:13 PM
Interesting new preprint:
Polygenic contributions to lithium augmentation outcomes in antidepressant non-responders with unipolar depression: www.medrxiv.org/content/10.1...
Polygenic contributions to lithium augmentation outcomes in antidepressant non-responders with unipolar depression: www.medrxiv.org/content/10.1...
Reposted by Laura
Happy to share our newest work on #covid19 #hostgenetics ! An analysis of >1000 whole genomes with @kuludwig.bsky.social and Axel Schmidt at University of Bonn and Uniklinik Bonn, the DeCOI consortium and many colleagues from around Germany & beyond. #plospathogens
journals.plos.org/plospathogen...
journals.plos.org/plospathogen...
Systematic assessment of COVID-19 host genetics using whole genome sequencing data
Author summary After infection with SARS-CoV-2, symptoms vary widely. On average, individuals who are older, males and those with certain comorbidities tend to be more severely affected by COVID-19. A...
journals.plos.org
January 8, 2025 at 9:50 AM
Happy to share our newest work on #covid19 #hostgenetics ! An analysis of >1000 whole genomes with @kuludwig.bsky.social and Axel Schmidt at University of Bonn and Uniklinik Bonn, the DeCOI consortium and many colleagues from around Germany & beyond. #plospathogens
journals.plos.org/plospathogen...
journals.plos.org/plospathogen...
Reposted by Laura
✨Psygenomics Lab escapes the psych ward! ✨
We had a lot of fun at our early Christmas outing at the psychiatry-themed escape room! 🧠🕵️♀️🎄
We had a lot of fun at our early Christmas outing at the psychiatry-themed escape room! 🧠🕵️♀️🎄
November 26, 2024 at 4:34 PM
✨Psygenomics Lab escapes the psych ward! ✨
We had a lot of fun at our early Christmas outing at the psychiatry-themed escape room! 🧠🕵️♀️🎄
We had a lot of fun at our early Christmas outing at the psychiatry-themed escape room! 🧠🕵️♀️🎄
Happy new year! (It‘s been a while since I enjoyed the vast horizons on bluesky…)
January 8, 2024 at 6:36 PM
Happy new year! (It‘s been a while since I enjoyed the vast horizons on bluesky…)
Reposted by Laura
New paper by Andy Dahl and I on phenotype integration improving GWAS power while preserving specificity is now out in Nature Genetics 🧬🎉 thank you all collaborators and reviewers!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Phenotype integration improves power and preserves specificity in biobank-based genetic studies of m...
Phenotype imputation increases the effective sample size of major depressive disorder cases in UK Biobank, enhancing study power and polygenic risk score (PRS) accuracy. A new pleiotropy metric enable...
www.nature.com
November 21, 2023 at 1:23 PM
New paper by Andy Dahl and I on phenotype integration improving GWAS power while preserving specificity is now out in Nature Genetics 🧬🎉 thank you all collaborators and reviewers!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Laura
My current view of psychological/psychiatric science: we have to be an order of magnitude more ambitions about the quality and quantity of the data we collect; in order to answer questions that are an order of magnitude more modest than the questions we think we can answer.
December 6, 2023 at 6:52 PM
My current view of psychological/psychiatric science: we have to be an order of magnitude more ambitions about the quality and quantity of the data we collect; in order to answer questions that are an order of magnitude more modest than the questions we think we can answer.
Does anyone happen to have access to this article? www.sciencedirect.com/science/arti...
Patient with Progressive Supranuclear Palsy Initially Diagnosed as Anxiety and Depression
La parálisis supranuclear progresiva (PSP) incluye un amplio espectro de síndromes relacionados con trastornos del movimiento y el comportamiento. Los…
www.sciencedirect.com
December 5, 2023 at 6:40 PM
Does anyone happen to have access to this article? www.sciencedirect.com/science/arti...
Reposted by Laura
Non-coding rare variant associations with blood traits on 166,740 UK Biobank genomes https://www.biorxiv.org/content/10.1101/2023.12.01.569422v1
Non-coding rare variant associations with blood traits on 166,740 UK Biobank genomes https://www.biorxiv.org/content/10.1101/2023.12.01.569422v1
Large biobanks with whole-genome sequencing now enable the association of non-coding rare variants w
www.biorxiv.org
December 4, 2023 at 2:35 PM
Non-coding rare variant associations with blood traits on 166,740 UK Biobank genomes https://www.biorxiv.org/content/10.1101/2023.12.01.569422v1
No, I didn’t get everything… www.nature.com/articles/s41...
Learning few-shot imitation as cultural transmission - Nature Communications
The modelling of human-like behaviours is one of the challenges in the field of Artificial Intelligence. Inspired by experimental studies of cultural evolution, the authors propose a reinforcemen...
www.nature.com
December 1, 2023 at 10:31 AM
No, I didn’t get everything… www.nature.com/articles/s41...
@nbkroemer.bsky.social Congratulations on your DGPPN prize!
November 29, 2023 at 7:38 PM
@nbkroemer.bsky.social Congratulations on your DGPPN prize!
The BeeGees are not your thing? Well, the German Society for Anaesthesiology and the Professional Association of German Anaesthesiologists have created a Spotify playlist of songs suitable for keeping pace with the 100bpm needed for CPR: www.daebl.de/SR59. (Source: Deutsches Ärzteblatt)
100BPM - der Rhythmus der Herzdruckmassage
100BPM - der Rhythmus der Herzdruckmassage · Playlist · 86 songs · 324 likes
www.daebl.de
November 27, 2023 at 7:06 PM
The BeeGees are not your thing? Well, the German Society for Anaesthesiology and the Professional Association of German Anaesthesiologists have created a Spotify playlist of songs suitable for keeping pace with the 100bpm needed for CPR: www.daebl.de/SR59. (Source: Deutsches Ärzteblatt)
Reposted by Laura
Genomic Medicine in 2023 open.substack.com/pub/albertvi...
Genomic Medicine in 2023
In the broad sense, the term "genomic medicine" encompasses various approaches and techniques that involve the analysis of biologically relevant molecules within an individual's genome. While genome s...
open.substack.com
November 26, 2023 at 5:00 PM
Genomic Medicine in 2023 open.substack.com/pub/albertvi...
Reposted by Laura
Heritability of complex traits in sub-populations experiencing bottlenecks and growth https://www.biorxiv.org/content/10.1101/2023.11.23.568467v1
Heritability of complex traits in sub-populations experiencing bottlenecks and growth https://www.biorxiv.org/content/10.1101/2023.11.23.568467v1
Populations that have experienced a bottleneck are regularly used in Genome Wide Association Studies
www.biorxiv.org
November 24, 2023 at 12:37 AM
Heritability of complex traits in sub-populations experiencing bottlenecks and growth https://www.biorxiv.org/content/10.1101/2023.11.23.568467v1
Reposted by Laura
🧪 Study of over a million genomes reveals links between specific genomic regions and cannabis addiction. These regions also relate to schizophrenia & lung cancer. Further, a two-way relationship between heavy cannabis use and schizophrenia is identified, highlighting potential mutual influence. 🩺🧬🖥️
Massive genetic study finds genes linked to cannabis addiction
Data from more than one million genomes offer fresh insights into excessive cannabis use and its relationship to other diseases. Data from more than one million genomes offer fresh insights into exces...
www.nature.com
November 21, 2023 at 4:22 PM
🧪 Study of over a million genomes reveals links between specific genomic regions and cannabis addiction. These regions also relate to schizophrenia & lung cancer. Further, a two-way relationship between heavy cannabis use and schizophrenia is identified, highlighting potential mutual influence. 🩺🧬🖥️
Reposted by Laura
Wichtige Beobachtungsstudie bei PCS: Antidepressiva aus der Gruppe der SSRI, die Serotonin erhöhen, führten bei 90% zu Besserung
Hier die klinische Studie:
www.nature.com/articles/s41...
Hier die klinische Studie:
www.nature.com/articles/s41...
Treatment of 95 post-Covid patients with SSRIs - Scientific Reports
Scientific Reports - Treatment of 95 post-Covid patients with SSRIs
www.nature.com
November 5, 2023 at 2:54 PM
Wichtige Beobachtungsstudie bei PCS: Antidepressiva aus der Gruppe der SSRI, die Serotonin erhöhen, führten bei 90% zu Besserung
Hier die klinische Studie:
www.nature.com/articles/s41...
Hier die klinische Studie:
www.nature.com/articles/s41...
Another one for the „to read“-list: Genetic Liability to Posttraumatic Stress Disorder Symptoms and Its Association With Cardiometabolic and Respiratory Outcomes
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
November 3, 2023 at 9:12 AM
Another one for the „to read“-list: Genetic Liability to Posttraumatic Stress Disorder Symptoms and Its Association With Cardiometabolic and Respiratory Outcomes
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Reposted by Laura
The diffuse inflammation of the brain in symptomatic people with Long Covid by PET scans, with matched controls, and correlation with their blood inflammatory biomarkers
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
October 21, 2023 at 4:25 PM
The diffuse inflammation of the brain in symptomatic people with Long Covid by PET scans, with matched controls, and correlation with their blood inflammatory biomarkers
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Laura
www.pnas.org/doi/full/10....
The immune cell census in the human body! These ~2 trillion cells collectively weigh ~1.2 kg, 40% are lymphocytes, 10% macrophages
The immune cell census in the human body! These ~2 trillion cells collectively weigh ~1.2 kg, 40% are lymphocytes, 10% macrophages
October 23, 2023 at 8:56 PM
www.pnas.org/doi/full/10....
The immune cell census in the human body! These ~2 trillion cells collectively weigh ~1.2 kg, 40% are lymphocytes, 10% macrophages
The immune cell census in the human body! These ~2 trillion cells collectively weigh ~1.2 kg, 40% are lymphocytes, 10% macrophages
Special collection of 21 papers showcasing a multi-omics analysis of the human brain at the cell-type level: www.science.org/collections/...
Brain cell census | Collections | AAAS
www.science.org
October 28, 2023 at 2:28 PM
Special collection of 21 papers showcasing a multi-omics analysis of the human brain at the cell-type level: www.science.org/collections/...
Interesting study on distinguishing bipolar disorder, currently depressed, from major depressive disorder, which is obviously rather relevant in everyday clinical work.. jamanetwork.com/journals/jam...
Metabolomic Biomarker Signatures for Bipolar and Unipolar Depression
This diagnostic study evaluates a reproducible metabolomic biomarker signature in patient dried blood spots that differentiates bipolar disorder from major depr
jamanetwork.com
October 27, 2023 at 5:35 PM
Interesting study on distinguishing bipolar disorder, currently depressed, from major depressive disorder, which is obviously rather relevant in everyday clinical work.. jamanetwork.com/journals/jam...
Reposted by Laura
It took us 11 years but: Dopaminergic systems create reward seeking despite adverse consequences
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Dopaminergic systems create reward seeking despite adverse consequences - Nature
In Drosophila, a subpopulation of reward-encoding dopaminergic neurons antagonizes punishment-encoding neurons and can override punishment or hunger cues in favour of reward-seeking behaviour.
www.nature.com
October 25, 2023 at 3:23 PM
It took us 11 years but: Dopaminergic systems create reward seeking despite adverse consequences
www.nature.com/articles/s41...
www.nature.com/articles/s41...