Joel Topf
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kidneyboy.bsky.social
Joel Topf
@kidneyboy.bsky.social
Saying the product of the kidneys is urine is like saying the product of a factory is pollution. Urine is a by-product. The product is homeostasis.

COI: https://pbfluids.com/about/
Recording another @FreelyFiltered. This one with Jon Barratt. Talking atacicet and IgAN!
November 14, 2025 at 9:54 PM
Summary

#KidneyWk
November 8, 2025 at 5:40 PM
Safety is impressive
#KidneyWk
November 8, 2025 at 5:40 PM
Hematuria and remission data is equally impressive
#KidneyWk
November 8, 2025 at 5:40 PM
This stuff knocks the stuffing out proteinuria
#KidneyWk
November 8, 2025 at 5:40 PM
Table 1
#KidneyWk
November 8, 2025 at 5:40 PM
Study design
#KidneyWk
November 8, 2025 at 5:40 PM
April is important in IgAN
#KidneyWk
November 8, 2025 at 5:40 PM
Visionary trial has 240 sites around the globe but my site is the best.
#KidneyWk
November 8, 2025 at 5:40 PM
Vlado up for Sibe in IgAN

With some new data and some old data
#KidneyWk
November 8, 2025 at 5:40 PM
People (including me) are hating on CSA as comparator but @sophia_kidney reminded me that ritux in mentor went against CSA and was only non-inferior not superior

www.nejm.org/doi/full/10....
November 8, 2025 at 5:25 PM
November 8, 2025 at 5:21 PM
Secondary outcomes are as expected with primary outcome
#KidneyWk
November 8, 2025 at 5:21 PM
Rapid and Durable response
#KidneyWk
November 8, 2025 at 5:21 PM
It beat cyclosporine
Across sub groups
And immunologic remission
#KidneyWk
November 8, 2025 at 5:21 PM
Phase 3 study design
#KidneyWk
November 8, 2025 at 5:21 PM
Fully humanized anti-CD20
Doesn't depend on compliment for for cytotoxicity

Deeper and more durable B-cell depletion

Phase 2 showed it to be effective vs CSA 🤷🏻‍♂️
November 8, 2025 at 5:21 PM
Cui for a study of membranous with MIL62

#KidneyWk
November 8, 2025 at 5:21 PM
Amazing #KidneyWk run
November 8, 2025 at 1:53 PM
If you are coming to the NephJC party tonight catch the bus at 7:00 at the corner Avenida De Las Americas & Rusk St at the corner of the conference center nearest Hall A. Near the restaurant, Grotto.
November 7, 2025 at 11:19 PM
Mid career award winners #KidneyWk
November 7, 2025 at 2:04 PM
Panel discussion. What's your limit

<8 Sterns
<8 Rondon
6 Fabrice

#KidneyWk
November 6, 2025 at 6:17 PM
If you ever get to give a plenary talk pay for the stock photo!

🤦🏻‍♂️

#KidneyWk
November 6, 2025 at 3:34 PM
You'd think insulin would make the list

#KidneyWk
November 6, 2025 at 3:31 PM
Up next a panel discussion about the trials #KidneyWk
November 6, 2025 at 3:21 PM