Joel Topf
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kidneyboy.bsky.social
Joel Topf
@kidneyboy.bsky.social
Saying the product of the kidneys is urine is like saying the product of a factory is pollution. Urine is a by-product. The product is homeostasis.

COI: https://pbfluids.com/about/
Because you don't subscribe to the NephJC newsletter.
November 9, 2025 at 10:24 PM
Summary

#KidneyWk
November 8, 2025 at 5:40 PM
Safety is impressive
#KidneyWk
November 8, 2025 at 5:40 PM
Hematuria and remission data is equally impressive
#KidneyWk
November 8, 2025 at 5:40 PM
This stuff knocks the stuffing out proteinuria
#KidneyWk
November 8, 2025 at 5:40 PM
Table 1
#KidneyWk
November 8, 2025 at 5:40 PM
Study design
#KidneyWk
November 8, 2025 at 5:40 PM
April is important in IgAN
#KidneyWk
November 8, 2025 at 5:40 PM
Visionary trial has 240 sites around the globe but my site is the best.
#KidneyWk
November 8, 2025 at 5:40 PM
People (including me) are hating on CSA as comparator but @sophia_kidney reminded me that ritux in mentor went against CSA and was only non-inferior not superior

www.nejm.org/doi/full/10....
November 8, 2025 at 5:25 PM
November 8, 2025 at 5:21 PM
Secondary outcomes are as expected with primary outcome
#KidneyWk
November 8, 2025 at 5:21 PM
Rapid and Durable response
#KidneyWk
November 8, 2025 at 5:21 PM
It beat cyclosporine
Across sub groups
And immunologic remission
#KidneyWk
November 8, 2025 at 5:21 PM
Phase 3 study design
#KidneyWk
November 8, 2025 at 5:21 PM
Fully humanized anti-CD20
Doesn't depend on compliment for for cytotoxicity

Deeper and more durable B-cell depletion

Phase 2 showed it to be effective vs CSA 🤷🏻‍♂️
November 8, 2025 at 5:21 PM
We were disappointed you weren't presenting. But at least he did not say Alport's
November 8, 2025 at 5:10 PM
Reposted by Joel Topf
Richard Haynes- professor at Oxford, nephrologist. Senior author EMPA-k , 3C etc etc…..
November 8, 2025 at 5:05 PM