Vote for @martinpacesa.bsky.social ‘s designs in the adaptyv nipah virus competition: proteinbase.com/collections/.... because they’ll actually bind

Fold-Conditioned De Novo Binder Design via AlphaFold2-Multimer Hallucination. [new]
FoldCraft: uses AlphaFold2-Multimer with contact map loss to hallucinate novel binders with user-defined folds, improving nanobody design.

Fold-Conditioned De Novo Binder Design via AlphaFold2-Multimer Hallucination. https://www.biorxiv.org/content/10.1101/2025.07.02.662497v1

🧬 "MSA clustering enhances AF-Multimer's ability to predict conformational landscapes of protein-protein interactions" explores how MSA sampling improves #AlphaFold's performance in predicting binding mechanisms for proteins with multiple states. Learn more: doi.org/10.1093/bioa... #ProteinFolding