I am excited to share the second half of my postdoctoral work in the Yeo lab at UCSD! We found that neuronal aging leads to the accumulation of mitochondrial double-stranded RNA, which triggers the chronic stress response. 1/ www.biorxiv.org/content/10.1...

I am excited to share that I will be starting my lab @uarizona.bsky.social this summer! Our research will focus on how aging impacts neuronal resilience and RNA biology; we will be part of the Coit Center for Longevity & Neurotherapeutics. sites.arizona.edu/rhine-lab/

Neuronal aging leads to widespread dysregulation of RNA biology, including mislocalization of splicing proteins like TDP-43, chronic cellular stress, and reduced resiliency

@kevinrhine.bsky.social

www.nature.com/articles/s41...

The Research Briefing accompanying our paper is now out too! www.nature.com/articles/s41...

Excited to share my postdoctoral research on how neuronal #aging contributes to RNA dysfunction is now online at Nature Neuroscience! Here we find that aged neurons suffer from chronic cellular stress that compromises resiliency to new stressors🧪 www.nature.com/articles/s41...

Honored to be funded by the @alsassociation.bsky.social and their Seed Grants Program! Aging-linked changes in TDP-43 biology don't stand a chance 😎 www.als.org/blog/catalyz...

Excited to share our latest work! We asked if and how TDP-43 regulates RNA transport in neurons and if this is misregulated in ALS. We found that it works to keep RNAs *out* of neurites, and that loss of TDP-43 activity results in specific RNAs aberrantly accumulating there.

Excited to share the preprint of the last portion of my grad work with co-first-author Gemechu Mekonnen and my adviser Sua Myong! We show that the RNA helicase DDX6 can tune the nucleation and fluidity of FUS condensates, including ALS-linked variants. Read more here: papers.ssrn.com/sol3/papers....