Ken Humphries
@ken-humphries.bsky.social
Associate Professor in the Aging and Metabolism Program at OMRF @am-omrf.bsky.social
My lab studies cardiac metabolism and a longtime mitochondriac 🧪🔬🫀☕️
My lab studies cardiac metabolism and a longtime mitochondriac 🧪🔬🫀☕️
Pinned
Ken Humphries
@ken-humphries.bsky.social
· Nov 12
Humphries lab, represent. Grad student, Kylene Harold, presenting her work on our PFKFB2 knockout mouse. 🫀
New publication from our lab with lots of contributions from my great @am-omrf.bsky.social colleagues. We examined the effect of enhanced glycolysis on cardiac aging. Read the full article here:
link.springer.com/article/10.1...
link.springer.com/article/10.1...
The effect of enhanced glycolysis on cardiac aging - GeroScience
Cardiac aging is associated with metabolic changes, including an increased reliance on glycolysis, and an increased susceptibility to cardiovascular diseases. This study explores the relationship betw...
link.springer.com
May 20, 2025 at 3:45 AM
New publication from our lab with lots of contributions from my great @am-omrf.bsky.social colleagues. We examined the effect of enhanced glycolysis on cardiac aging. Read the full article here:
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reposted by Ken Humphries
Grateful for the award! A major thanks to the Multiplexing Protein Analysis Core and folks at @am-omrf.bsky.social (like @benjaminfmiller.bsky.social) who were instrumental in gathering preliminary data for our NIH grant proposal.
We are so glad to highlight 2023 Oklahoma NSC Pilot Awardee Robert Musci! Check out the full Pilot Awardee Spotlight here: bit.ly/40Obn3A #AgingResearch @oknathanshock.bsky.social
January 28, 2025 at 1:51 AM
Grateful for the award! A major thanks to the Multiplexing Protein Analysis Core and folks at @am-omrf.bsky.social (like @benjaminfmiller.bsky.social) who were instrumental in gathering preliminary data for our NIH grant proposal.
Reposted by Ken Humphries
Recent paper from the Stout lab reveals Canagliflozin, a diabetes drug, may delay ovarian aging by preserving follicular reserves and improving mitochondrial function. Could this hold promise for delaying menopause and systemic aging in women? 🧬
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Canagliflozin treatment prevents follicular exhaustion and attenuates hallmarks of ovarian aging in genetically heterogenous mice - GeroScience
Ovarian aging is characterized by declines in follicular reserve and the emergence of mitochondrial dysfunction, reactive oxygen species production, inflammation, and fibrosis, which eventually result...
link.springer.com
January 10, 2025 at 5:44 PM
Recent paper from the Stout lab reveals Canagliflozin, a diabetes drug, may delay ovarian aging by preserving follicular reserves and improving mitochondrial function. Could this hold promise for delaying menopause and systemic aging in women? 🧬
link.springer.com/article/10.1...
link.springer.com/article/10.1...
I'm excited about this- in this study we identified a new inhibitor of PFKFB kinase activities and we're hopeful for future applications.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Mechanistic studies of PFKFB2 reveals a novel inhibitor of its kinase activity
The 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase (PFKFB) family of proteins are bifunctional enzymes that are of clinical relevance because of their roles in regulating glycolysis in insulin se...
www.biorxiv.org
December 29, 2024 at 9:29 PM
I'm excited about this- in this study we identified a new inhibitor of PFKFB kinase activities and we're hopeful for future applications.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Ken Humphries
Check it out ⤵️
Several of our scientists and outstanding trainees are on Bluesky.
go.bsky.app/5oUbpNy
Several of our scientists and outstanding trainees are on Bluesky.
go.bsky.app/5oUbpNy
November 23, 2024 at 6:29 PM
Check it out ⤵️
Several of our scientists and outstanding trainees are on Bluesky.
go.bsky.app/5oUbpNy
Several of our scientists and outstanding trainees are on Bluesky.
go.bsky.app/5oUbpNy
O-GlcNAc modification of enzymes within the N-glycosylation pathway impacts their function, revealing a connection between these two distinct glycosylation pathways.
www.cell.com/cell-reports...
www.cell.com/cell-reports...
O-GlcNAcylation modulates expression and abundance of N-glycosylation machinery in an inherited glycosylation disorder
Matheny-Rabun and colleagues discover that O-GlcNAc modification of rate-limiting
enzymes within the N-glycosylation pathway impacts their function, drawing a connection
between two spatially separate...
www.cell.com
November 20, 2024 at 2:02 PM
O-GlcNAc modification of enzymes within the N-glycosylation pathway impacts their function, revealing a connection between these two distinct glycosylation pathways.
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Sooo… with all the new users and resources, and without ads, what’s the business model on Bluesky? 🤔
November 19, 2024 at 3:13 PM
Sooo… with all the new users and resources, and without ads, what’s the business model on Bluesky? 🤔
Reposted by Ken Humphries
Where did we get our profile picture? The foyer at OMRF has an amazing artistic cell representation with inlaid marble #mitochondria
November 18, 2024 at 11:29 PM
Where did we get our profile picture? The foyer at OMRF has an amazing artistic cell representation with inlaid marble #mitochondria
Reposted by Ken Humphries
Isolated Mouse Adult Cardiomyocytes Display Minimal Mitochondrial ATP Demand and Maximal Reliance on Glycolysis
Isolated Mouse Adult Cardiomyocytes Display Minimal Mitochondrial ATP Demand and Maximal Reliance on Glycolysis https://www.biorxiv.org/content/10.1101/2024.11.17.623751v1
Isolated Mouse Adult Cardiomyocytes Display Minimal Mitochondrial ATP Demand and Maximal Reliance on Glycolysis https://www.biorxiv.org/content/10.1101/2024.11.17.623751v1
Mitochondrial maladaptation is a hallmark of heart failure, contributing to impaired energy producti
www.biorxiv.org
November 19, 2024 at 1:37 AM
Isolated Mouse Adult Cardiomyocytes Display Minimal Mitochondrial ATP Demand and Maximal Reliance on Glycolysis
Reposted by Ken Humphries
How’s this for a first post?
New publication in Nature Communications about the role of dopamine in Alzheimer’s disease⤵️
omrf.org/2024/11/12/o...
New publication in Nature Communications about the role of dopamine in Alzheimer’s disease⤵️
omrf.org/2024/11/12/o...
OMRF discovers new chemical link to Alzheimer’s
Findings may explain mood changes that precede disease
omrf.org
November 15, 2024 at 4:53 AM
How’s this for a first post?
New publication in Nature Communications about the role of dopamine in Alzheimer’s disease⤵️
omrf.org/2024/11/12/o...
New publication in Nature Communications about the role of dopamine in Alzheimer’s disease⤵️
omrf.org/2024/11/12/o...
#1 on App Store
November 15, 2024 at 4:25 AM
#1 on App Store
I was wondering how Bluesky gets away with being so similar to Twitter. It’s because it was a Twitter side project. en.m.wikipedia.org/wiki/Bluesky
Bluesky - Wikipedia
en.m.wikipedia.org
November 13, 2024 at 6:16 AM
I was wondering how Bluesky gets away with being so similar to Twitter. It’s because it was a Twitter side project. en.m.wikipedia.org/wiki/Bluesky
Reposted by Ken Humphries
In a world full of Twitters, be a Bluesky.
November 12, 2024 at 7:00 PM
In a world full of Twitters, be a Bluesky.
Humphries lab, represent. Grad student, Kylene Harold, presenting her work on our PFKFB2 knockout mouse. 🫀
November 12, 2024 at 7:31 PM
Humphries lab, represent. Grad student, Kylene Harold, presenting her work on our PFKFB2 knockout mouse. 🫀
Two foxes 🦊 🦊, one stray cat 🐈. Everyone gets along with just a little suspicion.
November 12, 2024 at 2:59 PM
Two foxes 🦊 🦊, one stray cat 🐈. Everyone gets along with just a little suspicion.
A cool moon halo tonight. 🌖 😇
November 12, 2024 at 4:03 AM
A cool moon halo tonight. 🌖 😇
First post! How about a picture of our backyard gray fox. 🦊 They’re finding a niche in urban areas.
November 11, 2024 at 5:13 PM
First post! How about a picture of our backyard gray fox. 🦊 They’re finding a niche in urban areas.